ACC 100 effervescent tablets 100 mg, 20 pcs. (Acetylcysteine)
Special Price
$22.10
Regular Price
$26.00
In stock
SKU
newyork475214
Latin name
ACC 100 Buy ACC 100 effervescent tablets 100 mg, 20 pcs. (Acetylcysteine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
ACC 100 Buy ACC 100 effervescent tablets 100 mg, 20 pcs. (Acetylcysteine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
ACC 100
packaging 20 pcs
Pharmacological action
Pharmacodynamics
Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to direct effect on the rheological properties of sputum.
The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause the depolymerization of mucoproteins of sputum, which leads to a decrease in the viscosity of sputum. The drug remains active in the presence of purulent sputum.
It has an antioxidant effect, based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and, thus, neutralize them.
In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.
Pharmacokinetics
Absorption is high. It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.
Oral bioavailability is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach maximum concentration (Cmax) in blood plasma is 1 to 3 hours. Communication with plasma proteins is 50%. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).
The half-life (T1 / 2) is about 1 hour, impaired liver function leads to an extension of T1 / 2 to 8 hours. Penetrates through the placental barrier. Data on the ability of acetylcysteine to cross the blood-brain barrier and excreted in breast milk are not available.
Indications
Respiratory diseases associated with the formation of viscous, difficult to separate sputum: acute and chronic
bronchitis, obstructive bronchitis
tracheitis, laryngotracheitis
pneumonia
lung abscess
bronchiectatic disease, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis
cystic fibrosis, and moderate otitis media (acute inflammation).
Contraindications
Hypersensitivity to acetylcysteine or other components of the drug
peptic ulcer of the stomach and duodenum in the acute stage
pregnancy
breastfeeding
hemoptysis, pulmonary hemorrhage
lactase deficiency, lactose intolerance, glucose-galactose malabsorption
children under 2 years of age (for this dosage form).
WITH CAUTION
history of gastric and duodenal ulcer, a history of asthma, obstructive bronchitis, liver and / or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine and can lead to intolerances such as headache, vasomotor rhinitis, pruritus), varicose veins of the esophagus, adrenal gland diseases, arterial hypertension.
Use during pregnancy and lactation
Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, so the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of its termination should be decided.
Composition
1 effervescent tablet contains: active substance:
acetylcysteine - 100, 00 mg
excipients:
citric acid anhydrous - 679.85 mg
sodium bicarbonate - 194.00 mg
sodium carbonate anhydrous - 97.00 mg
mannitol - 65.00 mg
lactose anhydrous - 75.00 mg
ascorbic acid - 12.50 mg
sodium saccharin - 6.00 mg
sodium citrate - 0.65 mg
blackberry flavor “B” - 20.00 mg.
Dosage and Administration
Inside, after meals.
Effervescent tablets should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours. An additional liquid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of administration is 5 to 7 days. In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy: adults and children over 14 years of age: 2 effervescent tablets 2 to 3 times a day (400 to 600 mg each)
children 6 to 14 years old: 1 effervescent tablet 3 times a day, or 2 effervescent tablets 2 times a day (300 - 400 mg)
children from 2 to 6 years: 1 effervescent tablet 2 to 3 times a day (200 - 300 mg).
Cystic fibrosis: children from 2 to 6 years old: 1 effervescent tablet 4 times a day (400 mg)
children over 6 years old: 2 effervescent tablets 3 times a day (600 mg).
Side effects of
According to the World Health Organization (WHO), unwanted effects are classified according to their frequency of development as follows: very often ( 1/10), often ( 1/100, allergic reactions
infrequently: skin itching, rash , exanthema, urticaria, angioedema, lowering blood pressure,
tachycardia is very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome)
Respiratory
system rarely: shortness of breath, bronchospasm (mainly in patients with bronchial asthma hyperresponsiveness)
From the sensory organs
infrequently: tinnitus
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.
Other
infrequently: headache, fever, isolated reports of the development of bleeding due to the presence of a hypersensitivity reaction, decreased platelet aggregation.
Drug Interaction
When acetylcysteine and antitussives are used concurrently, sputum stagnation may occur. When co-administered with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between the administration of antibiotics and acetylcysteine should be at least 2 h (except cefixime and loracarbene). Co-administration with vasodilating agents and nitroglycerin can lead to increased vasodilator action.
overdose
Symptoms: when mistaken or intentional overdose occurs, such as diarrhea, vomiting, stomach pain, heartburn and nausea.
Treatment: symptomatic.
Storage conditions
The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25 ° C.
Expiration
3 years.
Deystvuyuschee
acetylcysteine
pharmacy dispensing terms without a prescription
dosage form
dosage form
tablets soluble
ACC 100 effervescent tablets 100 mg, 20 pcs. (Acetylcysteine) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. ACC 100 effervescent tablets 100 mg, 20 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
ACC 100
packaging 20 pcs
Pharmacological action
Pharmacodynamics
Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to direct effect on the rheological properties of sputum.
The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause the depolymerization of mucoproteins of sputum, which leads to a decrease in the viscosity of sputum. The drug remains active in the presence of purulent sputum.
It has an antioxidant effect, based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and, thus, neutralize them.
In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.
Pharmacokinetics
Absorption is high. It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.
Oral bioavailability is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach maximum concentration (Cmax) in blood plasma is 1 to 3 hours. Communication with plasma proteins is 50%. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).
The half-life (T1 / 2) is about 1 hour, impaired liver function leads to an extension of T1 / 2 to 8 hours. Penetrates through the placental barrier. Data on the ability of acetylcysteine to cross the blood-brain barrier and excreted in breast milk are not available.
Indications
Respiratory diseases associated with the formation of viscous, difficult to separate sputum: acute and chronic
bronchitis, obstructive bronchitis
tracheitis, laryngotracheitis
pneumonia
lung abscess
bronchiectatic disease, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis
cystic fibrosis, and moderate otitis media (acute inflammation).
Contraindications
Hypersensitivity to acetylcysteine or other components of the drug
peptic ulcer of the stomach and duodenum in the acute stage
pregnancy
breastfeeding
hemoptysis, pulmonary hemorrhage
lactase deficiency, lactose intolerance, glucose-galactose malabsorption
children under 2 years of age (for this dosage form).
WITH CAUTION
history of gastric and duodenal ulcer, a history of asthma, obstructive bronchitis, liver and / or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine and can lead to intolerances such as headache, vasomotor rhinitis, pruritus), varicose veins of the esophagus, adrenal gland diseases, arterial hypertension.
Use during pregnancy and lactation
Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, so the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of its termination should be decided.
Composition
1 effervescent tablet contains: active substance:
acetylcysteine - 100, 00 mg
excipients:
citric acid anhydrous - 679.85 mg
sodium bicarbonate - 194.00 mg
sodium carbonate anhydrous - 97.00 mg
mannitol - 65.00 mg
lactose anhydrous - 75.00 mg
ascorbic acid - 12.50 mg
sodium saccharin - 6.00 mg
sodium citrate - 0.65 mg
blackberry flavor “B” - 20.00 mg.
Dosage and Administration
Inside, after meals.
Effervescent tablets should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours. An additional liquid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of administration is 5 to 7 days. In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy: adults and children over 14 years of age: 2 effervescent tablets 2 to 3 times a day (400 to 600 mg each)
children 6 to 14 years old: 1 effervescent tablet 3 times a day, or 2 effervescent tablets 2 times a day (300 - 400 mg)
children from 2 to 6 years: 1 effervescent tablet 2 to 3 times a day (200 - 300 mg).
Cystic fibrosis: children from 2 to 6 years old: 1 effervescent tablet 4 times a day (400 mg)
children over 6 years old: 2 effervescent tablets 3 times a day (600 mg).
Side effects of
According to the World Health Organization (WHO), unwanted effects are classified according to their frequency of development as follows: very often ( 1/10), often ( 1/100, allergic reactions
infrequently: skin itching, rash , exanthema, urticaria, angioedema, lowering blood pressure,
tachycardia is very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome)
Respiratory
system rarely: shortness of breath, bronchospasm (mainly in patients with bronchial asthma hyperresponsiveness)
From the sensory organs
infrequently: tinnitus
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.
Other
infrequently: headache, fever, isolated reports of the development of bleeding due to the presence of a hypersensitivity reaction, decreased platelet aggregation.
Drug Interaction
When acetylcysteine and antitussives are used concurrently, sputum stagnation may occur. When co-administered with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between the administration of antibiotics and acetylcysteine should be at least 2 h (except cefixime and loracarbene). Co-administration with vasodilating agents and nitroglycerin can lead to increased vasodilator action.
overdose
Symptoms: when mistaken or intentional overdose occurs, such as diarrhea, vomiting, stomach pain, heartburn and nausea.
Treatment: symptomatic.
Storage conditions
The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25 ° C.
Expiration
3 years.
Deystvuyuschee
acetylcysteine
pharmacy dispensing terms without a prescription
dosage form
dosage form
tablets soluble
ACC 100 effervescent tablets 100 mg, 20 pcs. (Acetylcysteine) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. ACC 100 effervescent tablets 100 mg, 20 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Submit your review to Earn 10 Reward Points click here to login
Write Your Own Review