Acetylsalicylic acid tablets 500 mg 10 pcs. (Atsetylsalytsylovaya acid)

Packing

10 pcs

Indications

Symptomatic treatment of

pain syndrome Headache - symptomatic treatment of

Toothache - symptomatic treatment of

Migraine pain - symptomatic treatment of

Sore throat - symptomatic treatment of

Pain in menstruation - back pain

Joint pain - symptomatic treatment

Elevated body temperature with colds and other infectious and inflammatory diseases (in adults and children over 15 years old)

Contraindications

- hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs or other components of the

drug - erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding, asthma bronchitis induced by the use of salicylates and non-steroidal anti-inflammatory drugs

- hemorrhagic diathesis

- combined use of methotrexate at a dose of 15 mg per week or more

- pregnancy, breastfeeding

- a combination of bronchial asthma, recurrent necrosis and necrosis of children age up to 12 years (for this dosage form).

The drug is not prescribed for children under 15 years of age with acute respiratory infections caused by viral infections, because of the risk of Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

With caution - with concomitant therapy with anticoagulants, gout, gastric ulcer and / or duodenal ulcer (history), including chronic or relapsing course of peptic ulcer, or episodes of gastrointestinal bleeding, renal and / or liver failure, glucose-6-phosphate dehydrogenase deficiency, hyperuricemia, bronchial asthma, chronic obstructive pulmonary disease, hay fever, nasal polyposis, drug allergy, simultaneous administration of methotrex dose less than 15 mg / week, pregnancy.

Use during pregnancy and lactation

Contraindicated for use in the I and III trimesters of pregnancy. In the II trimester of pregnancy, a single admission is possible according to strict indications.

It has a teratogenic effect: when used in the first trimester, it leads to the development of splitting of the upper palate, in the third trimester it causes inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to impaired platelet function, therefore, mother should not use acetylsalicylic acid during lactation

Composition

Active ingredient: acetylsalicylic acid - 500 mg.

Excipients: potato starch - 72.1 mg, citric acid - 0.2 mg, stearic acid - 6.0 mg, talc - 12.7 mg, colloidal silicon dioxide (aerosil) - 3.0 mg, sodium carboxymethyl starch (sodium starch glycolate, primogel) - 6.0 mg.

Dosage and administration

Inside, adults and children over 12 years of age: a single dose is 0.5 g, the maximum single dose is 1.0 g (2 tablets of 0.5 g), the maximum daily intake is 3, 0 g (6 tablets, 0 each 5 g).

Method of use: the drug should be taken after meals with water, milk or alkaline mineral water.

Frequency and time of administration: a single dose, if necessary, can be taken 3-4 times a day with an interval of at least 4 hours. Regular adherence to the drug can avoid a sharp increase in temperature and reduce the intensity of the pain syndrome.

The duration of treatment (without consulting a doctor) should not exceed 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic.

Side effects of the

Gastrointestinal tract: loss of appetite, diarrhea, abdominal pain, heartburn, nausea, vomiting, obvious (vomiting with blood, tarry stools) or latent signs of gastrointestinal bleeding, which can lead to iron deficiency anemia , erosive and ulcerative lesions (including with perforation) of the gastrointestinal tract, isolated cases - impaired liver function (increased hepatic transaminases).

From the central nervous system: dizziness, tinnitus (usually signs of an overdose).

From the hematopoietic system: increased risk of bleeding, which is a consequence of the effect of acetylsalicylic acid on platelet aggregation, thrombocytopenia, anemia, leukopenia.

Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, Quincke edema.

From the genitourinary system: impaired renal function.

Others: when taken as an antipyretic, Reye's syndrome (encephalopathy and acute fatty degeneration of the liver with rapid development of liver failure).

Drug Interaction

Co-administration:

- with methotrexate at a dose of 15 mg per week or more: raises the hemolytic cytotoxicity of methotrexate (decreases renal clearance of methotrexate and methotrexate is replaced by salicylates in connection with plasma proteins)

- with indirect anticoagulants and heparin: increases the risk of bleeding due to inhibition with blood plasma proteins

- with other non-steroidal anti-inflammatory drugs: as a result of synergistic interaction r sk ulcer and gastric bleeding

- with uricosuric drugs, for example, benzbromarone: reduces the uricosuric effect of

- with digoxin: concentration of digoxin increases due to decrease in renal excretion

- enhances the effects of oral hypoglycemic drugs

- with preparations of the group thrombolytics: bloodsheds increases, bloodsports, concentrations in the blood by increasing the excretion of the latter

- with angiotensin-converting fer inhibitors enta: snyzhaetsya glomerular filtering at the expense of inhibition and prostaglandins, As consequence, snyzhaetsya antihypertensive effect

- with valproevoy kyslotoy: pov shaetsya toxicity valproevoy acid

- with ethanol (alkoholn e drinks): increases the risk of damaging effects on the mucous membrane of the gastrointestinal tract and increases the risk of bleeding in the gastrointestinal tract

- enhances the effects of narcotic analgesics, thrombolytics and inhibitors of platelet aggregation, sulfonamide

plasma - magnesium and / or aluminum-containing antacids slow and worsen the absorption of acetylsalicylic acid

- myelotoxic drugs increase the appearance of hematotox chnosty drug

- usylyvaet эffekt triiodothyronine

- snyzhaet antihypertensive effect lekarstvenn h funds, diuretics (spironolactone, furosemide).

Glucocorticoids, ethanol and ethanol-containing drugs increase the damaging effect of acetylsalicylic acid on the mucous membrane of the gastrointestinal tract, increase the risk of gastrointestinal bleeding.

Overdose

Symptoms

Overdose of moderate severity: nausea, vomiting, tinnitus, hearing impairment, headache, dizziness and confusion.

Severe overdose: fever, hyperventilation, ketoacidosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.

Treatment: hospitalization, gastric lavage, activated carbon intake, monitoring of acid-base balance, alkaline diuresis to obtain urine pH between 7.5-8 (forced urination of urine is considered to be achieved if salicylate concentration in blood plasma is greater than 500 mg / l ( 3.6 mmol / l) in adults or 300 mg / l (2.2 mmol / l) in children), hemodialysis, fluid loss compensation, symptomatic therapy.

Storage conditions

In a dry place, at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Expiration

Expiration is 4 years.

Deystvuyuschee substances

Atsetylsalytsylovaya acid



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dosage form

dosage form

tablets

Pharmstandard-Leksredstva, Russia



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