Actiferrin drops for oral administration 30 ml (Iron Sulfate, Serine)

Latin name

Aktiferrin

Release form

Drops for oral administration

Packaging

In 1 bottle of 30 ml drops. In a cardboard bundle 1 bottle.

Pharmacological action

Actiferrin Drops for oral administration - iron preparation.

Iron is necessary for the life of the body: it is part of hemoglobin, myoglobin, a number of enzymes reversibly binds oxygen and is involved in a number of redox reactions and stimulates erythropoiesis. The alpha-amino acid serine, which is part of Actiferrin, promotes more efficient absorption of iron and its entry into the systemic circulation, which leads to a quick restoration of the normal iron content in the body. The inclusion of serine in the alpha amino acid can reduce the dose of iron, providing better tolerance to the drug.

When using the Actiferrin drug, iron deficiency in the body is quickly filled up, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.

Indications

Iron deficiency anemia of various etiologies.

Latent lack of iron in the body, associated with excessive loss of iron (bleeding) or with increased demand for it (period of active growth

Defective nutrition

Chronic gastritis with secretory insufficiency

Condition after resection of the stomach

Peptic ulcer of the stomach and duodenum

Decreased resistance of the body to infectious diseases).

Contraindications

Hemochromatosis, hemosiderosis

Other types of anemia not caused by iron deficiency in the body

Aplastic and hemolytic anemia

Siderohrestichnaya anemia, anemia with lead poisoning

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Use during pregnancy and lactation

With established iron deficiency in the body during pregnancy and lactation (breastfeeding), the use of Actiferrin is considered reasonable and safe.

Composition

In 1 ml (18 drops) contains:

Active ingredients

Iron sulfate (x 7H 2 O) 47.2 mg,

Including iron 9.48 mg.

D, L-serine 35.6 mg.

Excipients

Ascorbic acid, invert sugar syrup, potassium sorbate, ethanol 94%, raspberry flavor, creamy flavor, purified water.

Dosage and administration

For newborns and young children, the daily dose of Actiferrin is calculated based on 5 drops per 1 kg / drop 1 kg / dose - 2-3 times / day.

Average doses:

For infants, 10-15 drops 3 times / day.

For preschool children - 25-35 drops 3 times / day.

For schoolchildren - 50 drops 3 times / day.

Drops are taken with a little liquid (fruit tea or water).

Treatment with the drug is continued for at least 8-12 weeks after reaching normal levels of serum iron and hemoglobin, prescribing a maintenance dose.

Side effects of the

From the digestive system: rarely - a feeling of heaviness in the epigastric region, flatulence, constipation or diarrhea, which disappear with a decrease in dose.

Drug Interactions

Antacids, calcium drugs, gastric acid-lowering agents (including cimetidine, medicines containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, pancreatinolipyntitis the interval between administration of these drugs should be 1-2 h).

When used together, ascorbic acid increases iron absorption.

Actiferrin reduces the absorption of fluoroquinolones, penicillamine, tetracyclines (these drugs are recommended to be taken 2 h before or 2 h after iron administration).

Actifrin at high doses decreases renal absorption of zinc preparations (these drugs are recommended to be taken 2 h after administration of iron preparations).

Ethanol increases iron absorption and increases the risk of toxic complications.

overdose

Symptoms: at accidental administration of the drug in very high doses, weakness, fatigue, paresthesia, pallor of the skin, decrease in blood pressure, palpitations, acrocyanosis, abdominal pain, diarrhea with vomiting, vomiting, tingling , hyperthermia, lethargy, seizures, symptoms of hyperventilation, coma.

Signs of peripheral vascular collapse appear within 30 min after ingestion of metabolic acidosis, convulsions, fever, leukocytosis, coma - within 12-24 h acute renal and hepatic necrosis - in 2-4 days.

Treatment: before specific therapy - gastric lavage, milk intake, raw eggs. Specific therapy is carried out by the appointment of deferoxamine (desferal) inside and parenterally.

In acute poisoning for iron binding, which has not yet been absorbed from the gastrointestinal tract, give inside 5-10 g of diferoxamine by dissolving the contents of 10-20 ampoules in drinking water. For removal of absorbed iron, deferoxamine is injected in / m slowly, children - 15 mg / h, adults - 5 mg / kg / h (up to 80 mg / kg / day) with mild poisoning - in / m children 1 g every 4- 6 h, for adults - 50 mg / kg (up to 4 g / day).

In severe cases, accompanied by the development of shock, carry out in / in drip administration of the drug at a dose of 1 g and carry out symptomatic therapy.

Hemodialysis is ineffective for iron removal, but can be used to accelerate the removal of iron-deferroxamine complex, and can also be prescribed for oligo- and anuria. Peritoneal dialysis is possible.

Storage conditions

Store at a temperature not exceeding 25 ° C.

Expiration

2 years. After opening of the packing period of storage of drops: 1 month.

Terms

pharmacy leave with prescription

Dosage form

Dosage form

oral drops

Teva Pharmaceutical Enterprise Co., Ltd., Israel



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