Acyclovir Belupo cream for external use 5% 5 g (acyclovir)

Release form

5% cream for external use in aluminum tubes of 3, 5, 10 g. Together with the instructions for use, they are placed in a pack of cardboard.

Pharmacological action of

Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein Barr virus and cytomegaloviruses. The thymidine kinase of virus-infected cells activates acyclovir into acyclovir mono-, di- and triphosphate through a series of sequential reactions. The latter interacts with viral DNA polymerase and integrates into DNA, which is synthesized for new viruses. Thus, defective viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics: When used locally, it is practically not absorbed through damaged skin, and does not enter the systemic circulation.

Indications

Infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.

Precautions - pregnancy, lactation, dehydration, renal failure.

Pregnancy and lactation

There have been no adequate and well-controlled clinical trials of the safety of the drug during pregnancy. Use is indicated only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.

During the treatment period, it is necessary to resolve the issue of terminating breastfeeding.

Special instructions

To achieve the maximum therapeutic effect, it is necessary to start using the drug as soon as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness).

Cream is not recommended to be applied to the mucous membranes of the mouth and eyes, as the development of severe local inflammation is possible. When treating genital herpes, you should avoid sexual contact or use condoms, since the use of acyclovir does not prevent the transmission of the virus to partners.

Composition

Active ingredient - acyclovir 5 g

Excipients - nipazole. nipagin, cremophor A6. Cremophor A25. cetyl alcohol, propylene glycol, liquid paraffin, purified water.

Dosage and Administration

Externally. The drug is applied 5 times a day (every 4 hours) with a thin layer on the affected and adjacent skin areas. The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas. Therapy should be continued until the crust forms on the vesicles, or until they completely heal. The duration of therapy is an average of 5 days and should not exceed 10 days.

Side effects

Hyperemia, dryness, peeling of the skin, burning sensation, inflammation in contact with mucous membranes. Perhaps the development of allergic dermatitis.

Drug Interactions

With topical application, no interaction with other drugs was detected.

Storage Conditions

List B. At 12 to 15 ° C. Store inout of reach of children.

Expiration

2 years.

active substance

Acyclovir

Terms leave through pharmacies

without prescription

lekarstvennaja form

cream

For

For tall, children prescribed by a doctor, the doctor Pregnant intended

Indications

Indications

Cold, Herpes



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