Advantan cream 0.1%, 15 g (methylprednisolone atseponat)
Special Price
$26.35
Regular Price
$31.00
In stock
SKU
newyork462495
Release form
Cream 0.1%. Buy Advantan cream 0.1%, 15 g (methylprednisolone atseponat) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Cream 0.1%. Buy Advantan cream 0.1%, 15 g (methylprednisolone atseponat) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Cream 0.1%.
Packaging
Aluminum tube 15 g.
Pharmacological action of
corticosteroids for external use, is a non-halogenated synthetic steroid. When used externally, Advantan suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).
When using methylprednisolone aceponate externally, the systemic effect is minimally expressed in both humans and animals. After repeated application of Advantan to large surfaces (40-60% of the skin surface), as well as when applied under an occlusive dressing, there is no adrenal gland dysfunction: the level of cortisol in the blood plasma and its circadian rhythm remain within normal limits, the level of cortisol in the daily urine does not decrease going on.
In clinical trials with the use of Advantan in the form of an ointment, cream, oily ointment or emulsion for up to 12 weeks in adults and up to 4 weeks in children (including young children), no development of atrophy of the skin, telangiectasia, striae and acne-like rashes.
Methylprednisolone aceponate (especially its main metabolite, 6β-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to specific sections of DNA, thus causing a series of biological effects.
In particular, the binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of an inflammatory mediator such as prostaglandins and leukotrienes.
Inhibition of GCS synthesis of vasodilating prostaglandins and potentiation of the vasoconstrictor action of adrenaline leads to a vasoconstrictor effect.
Indications
Inflammatory skin diseases that are sensitive to topical corticosteroids therapy:
- atopic dermatitis, neurodermatitis, childhood eczema
- true eczema
- microbial eczema
- occupational eczema
- dyshrotic contact dermatitis dermatitis.
Contraindications
- skin tuberculosis and skin manifestations of syphilis in the area of ​​application of the drug
- viral skin lesions in the area of ​​application of the drug (for example, chickenpox, shingles)
- rosacea, perioral dermatitis in the area of ​​application of the drug
manifestations of skin reaction
vaccination - children under 4 months of age
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
If you need to use the drug Advantan during pregnancy and lactation, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or infant.
In this category of patients, it is not recommended to use the drug for a long time on extensive skin surfaces.
Nursing mothers should not apply the drug to the mammary glands.
Special instructions
In the presence of bacterial dermatoses and / or dermatomycoses, in addition to Advantan therapy, specific antibacterial or antifungal treatment is necessary.
Avoid contact with eyes.
As with systemic corticosteroids, topical corticosteroids may cause glaucoma (for example, after high doses or for very long periods, using occlusive dressings or applying to the skin around the eyes).
Does not affect the ability to drive vehicles and work with mechanisms.
Composition of
1 g of cream contains:
methylprednisolone aceponate 1 mg.
Excipients:
decyl oleate - 100 mg,
glyceryl monostearate 40-55% - 85 mg,
cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) - 25 mg,
solid fat - 37 mg, srdlp 75 mg,
macrogol stearate - 30 mg,
glycerol 85% - 50 mg,
disodium edetate - 1 mg,
benzyl alcohol - 10 mg,
butylhydroxytoluene - 60 ?g,
purified water - 597.9.
Dosage and Administration
Externally.
Adults and children from 4 months of age apply the drug 1 time / day with a thin layer on the affected skin.
The continuous daily use of Advantan in the form of a cream is not more than 12 weeks for adults, not more than 4 weeks for children.
Advantan Cream is a dosage form with a low fat content and a high water content, therefore it is recommended for the treatment of acute inflammatory processes and the weeping stage of eczema in case of very oily skin, as well as in localizing the process both on smooth skin and on the scalp.
If the skin dries excessively with prolonged use of the cream, it is necessary to switch to the dosage form of Advantan.
Side effects
Typically, the drug is well tolerated.
Very rarely (in less than 0.01% of cases) local reactions such as itching, burning, erythema, and the formation of a vesicular rash can be observed. If the drug is used for more than 4 weeks and / or on an area of 10% or more of the body surface, the following reactions may occur: skin atrophy, telangiectasia, striae, acneiform skin changes, systemic effects due to absorption of a corticosteroid.
In clinical trials, none of the above side effects were observed with Advantan before 12 weeks in adults and up to 4 weeks in children.
In rare cases (0.01-0.1%), folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to one of the components of the drug can be observed.
Drug Interactions
Drug Interactions Advantan not described.
Overdose
In the study of the acute toxicity of methylprednisolone aceponate, no risk of acute intoxication was observed with excessive single external use (application of the drug to a large area under conditions favorable for absorption).
Symptoms: Skin atrophy (thinning of the skin, telangiectasia, stretch marks) can develop with excessively long and / or intensive topical application of ACS.
Treatment: Withdrawal.
Storage Conditions
The product should be stored at a temperature not exceeding 25 ° C.
Keep out of the reach and sight of children.
Shelf life
3 years.
Deystvuyushtee substance
methylprednisolone aceponate
Terms and conditions
Without a prescription
Dosage form
cream
Prescription
Prescription
Pregnant as prescribed by a doctor, For adults, Nursing 6 months old 18 months old, 6 months old Prescribing
Prescribing
Pregnant as prescribed by the doctor, Nursing mothers as prescribed by the doctor, Adults, Children 4 months and older
Advantan cream 0.1%, 15 g (methylprednisolone atseponat) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Advantan cream 0.1%, 15 g - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Cream 0.1%.
Packaging
Aluminum tube 15 g.
Pharmacological action of
corticosteroids for external use, is a non-halogenated synthetic steroid. When used externally, Advantan suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).
When using methylprednisolone aceponate externally, the systemic effect is minimally expressed in both humans and animals. After repeated application of Advantan to large surfaces (40-60% of the skin surface), as well as when applied under an occlusive dressing, there is no adrenal gland dysfunction: the level of cortisol in the blood plasma and its circadian rhythm remain within normal limits, the level of cortisol in the daily urine does not decrease going on.
In clinical trials with the use of Advantan in the form of an ointment, cream, oily ointment or emulsion for up to 12 weeks in adults and up to 4 weeks in children (including young children), no development of atrophy of the skin, telangiectasia, striae and acne-like rashes.
Methylprednisolone aceponate (especially its main metabolite, 6β-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to specific sections of DNA, thus causing a series of biological effects.
In particular, the binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of an inflammatory mediator such as prostaglandins and leukotrienes.
Inhibition of GCS synthesis of vasodilating prostaglandins and potentiation of the vasoconstrictor action of adrenaline leads to a vasoconstrictor effect.
Indications
Inflammatory skin diseases that are sensitive to topical corticosteroids therapy:
- atopic dermatitis, neurodermatitis, childhood eczema
- true eczema
- microbial eczema
- occupational eczema
- dyshrotic contact dermatitis dermatitis.
Contraindications
- skin tuberculosis and skin manifestations of syphilis in the area of ​​application of the drug
- viral skin lesions in the area of ​​application of the drug (for example, chickenpox, shingles)
- rosacea, perioral dermatitis in the area of ​​application of the drug
manifestations of skin reaction
vaccination - children under 4 months of age
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
If you need to use the drug Advantan during pregnancy and lactation, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or infant.
In this category of patients, it is not recommended to use the drug for a long time on extensive skin surfaces.
Nursing mothers should not apply the drug to the mammary glands.
Special instructions
In the presence of bacterial dermatoses and / or dermatomycoses, in addition to Advantan therapy, specific antibacterial or antifungal treatment is necessary.
Avoid contact with eyes.
As with systemic corticosteroids, topical corticosteroids may cause glaucoma (for example, after high doses or for very long periods, using occlusive dressings or applying to the skin around the eyes).
Does not affect the ability to drive vehicles and work with mechanisms.
Composition of
1 g of cream contains:
methylprednisolone aceponate 1 mg.
Excipients:
decyl oleate - 100 mg,
glyceryl monostearate 40-55% - 85 mg,
cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) - 25 mg,
solid fat - 37 mg, srdlp 75 mg,
macrogol stearate - 30 mg,
glycerol 85% - 50 mg,
disodium edetate - 1 mg,
benzyl alcohol - 10 mg,
butylhydroxytoluene - 60 ?g,
purified water - 597.9.
Dosage and Administration
Externally.
Adults and children from 4 months of age apply the drug 1 time / day with a thin layer on the affected skin.
The continuous daily use of Advantan in the form of a cream is not more than 12 weeks for adults, not more than 4 weeks for children.
Advantan Cream is a dosage form with a low fat content and a high water content, therefore it is recommended for the treatment of acute inflammatory processes and the weeping stage of eczema in case of very oily skin, as well as in localizing the process both on smooth skin and on the scalp.
If the skin dries excessively with prolonged use of the cream, it is necessary to switch to the dosage form of Advantan.
Side effects
Typically, the drug is well tolerated.
Very rarely (in less than 0.01% of cases) local reactions such as itching, burning, erythema, and the formation of a vesicular rash can be observed. If the drug is used for more than 4 weeks and / or on an area of 10% or more of the body surface, the following reactions may occur: skin atrophy, telangiectasia, striae, acneiform skin changes, systemic effects due to absorption of a corticosteroid.
In clinical trials, none of the above side effects were observed with Advantan before 12 weeks in adults and up to 4 weeks in children.
In rare cases (0.01-0.1%), folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to one of the components of the drug can be observed.
Drug Interactions
Drug Interactions Advantan not described.
Overdose
In the study of the acute toxicity of methylprednisolone aceponate, no risk of acute intoxication was observed with excessive single external use (application of the drug to a large area under conditions favorable for absorption).
Symptoms: Skin atrophy (thinning of the skin, telangiectasia, stretch marks) can develop with excessively long and / or intensive topical application of ACS.
Treatment: Withdrawal.
Storage Conditions
The product should be stored at a temperature not exceeding 25 ° C.
Keep out of the reach and sight of children.
Shelf life
3 years.
Deystvuyushtee substance
methylprednisolone aceponate
Terms and conditions
Without a prescription
Dosage form
cream
Prescription
Prescription
Pregnant as prescribed by a doctor, For adults, Nursing 6 months old 18 months old, 6 months old Prescribing
Prescribing
Pregnant as prescribed by the doctor, Nursing mothers as prescribed by the doctor, Adults, Children 4 months and older
Advantan cream 0.1%, 15 g (methylprednisolone atseponat) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Advantan cream 0.1%, 15 g - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
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