Anaprilin tablets 10 mg, 50 pcs. (Propranolol)

Latin name

Anaprilin

Release form

tablets



packaging 50 pcs

Pharmacological action

Anaprilin is a non-selective beta-blocker (acts on beta1 and beta2-adrenergic receptors). It has antianginal, hypotensive and antiarrhythmic effects. It reduces the automatism of the sinus node, reduces heart rate, slows down AV conduction, reduces myocardial contractility, and reduces myocardial oxygen demand. It reduces the excitability of cardiomyocytes, reduces the occurrence of ectopic foci, and has a membrane-stabilizing effect. It has a hypotensive effect, which stabilizes by the end of the 2nd week of the course of the drug. Increases the tone of the bronchi.

Indications

- arterial hypertension

- angina pectoris, unstable angina

- sinus tachycardia (including hyperthyroidism)

- supraventricular tachycardia, tachysystolic form of atrial fibrillation

- supraventricular and ventricular extrasystole

- essential tremor

- fear syndrome

- prevention of migraine

- thyrotoxic crisis.

Contraindications

- AV block II and III degree, sinoatrial blockade

- bradycardia (heart rate less than 55 beats per min)

- sinus node weakness syndrome (SSS)

- arterial hypotension

- chronic heart failure II, s-stage III acute heart failure

- vasomotor rhinitis

- Raynaud's disease and other obliterating vascular diseases

- metabolic acidosis.

Use during pregnancy and lactation

During pregnancy, Anaprilin is prescribed with caution, and should be discontinued 48-72 hours before birth. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Composition

1 tablet contains:

Active ingredient: 10 mg propranolol

Excipients: sugar milk talcum starch potato calcium stearate.

Dosage and administration

Individual. When taken orally, the initial dose is 20 mg, a single dose is 40-80 mg, the maximum daily dose is 320 mg, and the frequency of administration is 2-3 times a day.

Side effects

Possible: bradycardia, AV block, bronchospasm, heart failure, muscle weakness.

Rarely - headache, sleep disturbances, nightmares, asthenia, decreased ability to quickly psychic and motor reactions, agitation, depression, paresthesia and cold extremities, nausea, diarrhea, constipation, allergic skin reactions, exacerbation of psoriasis, hypoglycemia, visual impairment, keratoconjunctivitis.

Drug Interaction

Against the background of treatment with Anaprilin, the administration of verapamil, diltiazem, should be avoided.

Concomitant administration of Anaprilin with oral hypoglycemic agents or insulin may impair glucose and blood plasma regulation and increase the risk of hyperglycemia.

Anaprilin can also mask the symptoms of onset hypoglycemia.

At simultaneous use of Anaprilin and NSAIDs (especially indomethacin) it is possible to reduce the antihypertensive action of Anaprilin, probably by suppressing the synthesis of prostaglandins in the kidneys and, as a consequence, the retention of sodium and fluid in the body).

With the simultaneous use of Anaprilin and estrogen-containing drugs, the antihypertensive effect of Anaprilin may be reduced due to fluid retention in the body.

With the use of Anaprilin with nitrates, the antihypertensive effect may increase.

Overdose

Symptoms: severe bradycardia, dizziness, AV blockade, severe BP, syncope, arrhythmia, ventricular extrasystole, CH, cyanosis of finger nails or palms, convulsions, difficulty breathing, bronchospasm.

Treatment: gastric lavage, appointment of activated charcoal, in violation of AV conductivity - 1-2 mg of atropine is injected, low staging of ventricular pacemaker is performed with ventricular extrasystole - lidocaine (Ia class drugs are not used) when reducing blood pressure. in the position of Trendelenburg.

If there are no signs of pulmonary edema, plasma replacement solutions are introduced into / into, in case of inefficiency - epinephrine, dopamine, dobutamine in CH - cardiac glycosides, diuretics, glucagon in convulsions - in / in diazepam with bronchospasm - inorenno.

Storage conditions

Store in a dry, dark place, out of the reach of children.

Expiration

4 years.

Deystvuyuschee substances

Propranolol

Pharmacy

Prescription

dosage form

dosage form

tablets

Tatkhimpharmpreparaty, Russia



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