AnviMax capsules, 20 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate)
Special Price
$22.10
Regular Price
$26.00
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SKU
newyork471401
Release form
capsule set Buy AnviMax capsules, 20 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
capsule set Buy AnviMax capsules, 20 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
capsule set
Packing
20 pcs.
Pharmacological action
Pharmacotherapeutic group
acute respiratory infections and "colds" symptoms remedy.
ATX code: R05X
Pharmacological properties of
Pharmacodynamics
Combined drug with antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects. Paracetamol has an analgesic and antipyretic effect.
Ascorbic acid is involved in the regulation of redox processes, promotes normal capillary permeability, blood coagulation, tissue regeneration, plays a positive role in the development of the body's immune responses, and replenishes vitamin C deficiency.
Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels causing hemorrhagic processes of influenza and acute respiratory viral infection (ARVI), has an antiallergic effect (mechanism unclear).
Rimantadine has antiviral activity against influenza A virus. By blocking the M2 channels of influenza A virus, it impairs its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of virus replication. Induces the production of interferons alpha and gamma. In influenza caused by virus B, rimantadine has an antitoxic effect.
Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of deformation of red blood cells.
Loratadine - a blocker of H1-histamine receptors, prevents the development of tissue edema associated with the release of histamine.
Pharmacokinetics of
Paracetamol. Absorption is high. Communication with plasma proteins - 15%. Penetrates through the blood-brain barrier. It is metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation with microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercapturic acid. The main isoenzymes of cytochrome P450 for this pathway of metabolism are the isoenzyme CYP2E1 (predominantly), CYP1A2 and CYP3A4 (secondary role). With glutathione deficiency, these metabolites can also cause necroshepatocyte damage. Additional metabolic pathways include hydroxylation of 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated paracetamol metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. It is excreted by the kidneys as metabolites, mainly conjugates, only 3% unchanged. In elderly patients, the clearance of the drug decreases and the elimination half-life increases.
The maximum concentration (Cmax) of paracetamol in blood plasma is achieved when capsules are used after 1.20 ± 0.72 h and is 5.01 ± 1.70 μg / ml, the half-life (T1 / 2) is 3.04 ± 1, 01 h
Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Communication with plasma proteins - 25%. Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestines. The concentration of ascorbic acid in blood plasma is normally approximately 10-20 μg / ml. The time of maximum concentration in blood plasma after ingestion is 4 hours. It easily penetrates into white blood cells, platelets, and then into all tissues, the highest concentration is reached in glandular organs, white blood cells, liver and lens of the eye penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in red blood cells and in plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration. It is metabolized mainly in the liver to deoxy-ascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, through the sweat glands in an unchanged form and in the form of metabolites. Smoking and the use of ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), drastically reducing body reserves. It is excreted during hemodialysis.
Calcium gluconate. About 1 / 5-1 / 3 of the orally administered calcium gluconate is absorbed in the small intestine, this process depends on the presence of ergocalciferol, pH, dietary features and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) - by the intestine.
rimantadine. After oral administration, it is almost completely absorbed in the intestine. Absorption is slow. Communication with plasma proteins - about 40%. Distribution volume - 17-25 l / kg. Concentration in nasal secretion is 50% higher than plasma. Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged. In chronic renal failure, T1 / 2 increases by 2 times. In persons with renal failure and in the elderly, it may accumulate in toxic concentrations if the dose is not adjusted in proportion to a decrease in creatinine clearance. Hemodialysis has an insignificant effect on the clearance of rimantadine.
Cmaxrimantadine in blood plasma is achieved with capsules after 4.53 ± 2.52 hours and is 68.2 ± 26.6 ng / ml, T1 / 2-30.51 ± 9.83 hours.
Rutoside. The time of maximum concentration in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and to a lesser extent by the kidneys. T1 / 2— 10-25 h.
loratadine. Quickly and completely absorbed in the gastrointestinal tract. The maximum concentration in the elderly increases by 50%. Communication with plasma proteins - 97%. It is metabolized in the liver with the formation of the active metabolite of decarboethoxyloratadine with the participation of cytochrome CYP3A4 isoenzymes and to a lesser extent CYP2D6. Does not cross the blood-brain barrier. It is excreted by the kidneys and with bile. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics are practically unchanged.
Cmaxloratadine in blood plasma is reached after 2.92 ± 1.31 h and is 2.36 ± 1.53 ng / ml, T1 / 2-12.36 ± 6.84 h.
Indications
Treatment of type A flu, symptomatic treatment of colds, flu and SARS, accompanied by fever, chills, nasal congestion, sore throat, pain in joints and muscles, headache.
Contraindications
Hypersensitivity to one or more components, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase gastrointestinal bleeding hemophilia hemorrhagic diathesis hypoprothrombinemia portal hypertension avitaminosis K renal failure pregnancy, period of breastfeeding thyroid disease, acute kidney disease, liver disease (acute glomerulone acute hepatitis, or exacerbation of chronic diseases of these organs) chronic alcoholism hypercalcemia, pronounced hypercalcium Uriah nefrourolitiaz, sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias), lactose intolerance, lactase deficiency, glucose-galaktoznayamalabsorbtsiya.
Children under 18 years old.
Precautions
Limitation of use for epilepsy, cerebral atherosclerosis, diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, kidney stone disease, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (anemia).
Elderly patients with arterial hypertension (increased risk of hemorrhagic stroke due to rimantadine, which is part of the drug).
Special instructions
Duration of use - no more than 5 days.
It is necessary to carry out laboratory monitoring of blood counts.
Do not use if metastatic tumors are present.
Persons prone to ethanol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.
Effect on the ability to drive vehicles and other mechanisms requiring increased concentration of attention
Given the possible development of side effects (dizziness, drowsiness) during the treatment period, it is not recommended to drive vehicles and engage in other activities that require increased concentration of attention and high speed psychomotor reactions.
Compound sachet-action: 9 mg capsule 30 mg capsule , colloidal silicon dioxide 3 mg, lactose monohydrate 1.2 mg, magnesium stearate 3.8 mg, polysorbate 803 mg. The composition of the hard gelatin capsule: gelatin - 94.795 mg, patent blue dye (E 131) or diamond blue dye (E 133) - 0.265 mg, titanium dioxide (E 171) - 1.94 mg.
Capsule R. Active ingredients: ascorbic acid - 300 mg, calcium gluconate monohydrate - 100 mg, rimantadine hydrochloride - 50 mg, rutosidate trihydrate (in terms of rutoside) - 20 mg, loratadine - 3 mg excipients: potato starch - 2.2 mg, magnesium stearate - 4.8 mg. The composition of the hard gelatin capsule: gelatin - 94.064 mg, iron oxide dye yellow (E 172) - 0.97 mg, iron oxide red oxide (E 172) - 0.485 mg, crimson dye [Ponceau 4R] (E 124) - 0.511 mg, titanium dioxide (E 171) - 0.97 mg.
Dosage and Administration
Inside.
Adults: 1 capsule P of blue color and 1 capsule P of red color (single dose) 2-3 times
a day after meals with water. The interval between doses of the drug is 4-6 hours. Therapy course for the disappearance of the symptoms of the disease. AnviMax® should not be taken for more than 5 days. If symptom relief is not observed within 3 days after starting the drug, you should consult a doctor.
Side effects
Possible unwanted side reactions are indicated in accordance with the constituents.
From the central nervous system: increased irritability, drowsiness, tremors, hyperkinesia, dizziness, headache, flushing of the face.
From the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).
From the urinary system: moderate pollakiuria.
From the hemopoietic organs: changes in blood counts.
Allergic reactions: angioedema, anaphylactic shock, skin rash, itching, urticaria.
From the skin: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome) and acute generalized exanthematous pustulosis.
Other: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).
Experience with post-registration use of
During the use of the drug AnviMax®, cases of angioedema, fainting, fever, decreased blood pressure, urticaria, skin itching, erythema, hearing impairment, and sore throat were described.
If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor immediately.
Drug Interactions
Paracetamol reduces the effectiveness of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose. With simultaneous use with metoclopramide, an increase in the rate of absorption of paracetamol is possible. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.
Rimantadinus enhances the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.
Ascorbic acid increases the concentration of benzylpenicillin in the blood. It improves the absorption of iron preparations in the intestines (converts ferric to ferrous) and can increase iron excretion while used with deferoxamine. Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acids by the kidneys, increases the excretion of drugs having an alkaline reaction (including alkaloids). Reduces the blood concentration of oral contraceptives. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. With simultaneous use, it reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase urinary excretion of ascorbic acid. Reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
loratadine. CYP3A4 and CYP2D6 inhibitors increase the concentration of blood loratadine.
Overdose
Symptoms: within the first 24 hours after ingestion - pale skin, nausea, diarrhea, vomiting, epigastric pain, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation. Symptoms of liver dysfunction may occur 12-48 hours after overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma acute renal failure with tubular necrosis (including in the absence of severe liver damage).
Treatment: administration of SH-group donors and precursors for glutathione-methionine synthesis within 8-9 h after overdose and acetylcysteine for 8 h. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as by the time that has elapsed after its administration.
Storage conditions
In a dry place, at a temperature not exceeding 25 ° C.
Keep out of the reach and sight of children.
Shelf life
2 years.
Active ingredients about
Paracetamol, Ascorbic Acid, Rimantadine, Rutoside, Loratadine, Kalytsiya gluconate
Terms and conditions
without prescription
dosage form
capsules
Appointment
Appointment
Adult
Farmtsentr VILAR SA, Russia
AnviMax capsules, 20 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate) florida in pharmacy online. Cheap price, instruction, side effects, dosage. AnviMax capsules, 20 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
capsule set
Packing
20 pcs.
Pharmacological action
Pharmacotherapeutic group
acute respiratory infections and "colds" symptoms remedy.
ATX code: R05X
Pharmacological properties of
Pharmacodynamics
Combined drug with antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects. Paracetamol has an analgesic and antipyretic effect.
Ascorbic acid is involved in the regulation of redox processes, promotes normal capillary permeability, blood coagulation, tissue regeneration, plays a positive role in the development of the body's immune responses, and replenishes vitamin C deficiency.
Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels causing hemorrhagic processes of influenza and acute respiratory viral infection (ARVI), has an antiallergic effect (mechanism unclear).
Rimantadine has antiviral activity against influenza A virus. By blocking the M2 channels of influenza A virus, it impairs its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of virus replication. Induces the production of interferons alpha and gamma. In influenza caused by virus B, rimantadine has an antitoxic effect.
Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of deformation of red blood cells.
Loratadine - a blocker of H1-histamine receptors, prevents the development of tissue edema associated with the release of histamine.
Pharmacokinetics of
Paracetamol. Absorption is high. Communication with plasma proteins - 15%. Penetrates through the blood-brain barrier. It is metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation with microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercapturic acid. The main isoenzymes of cytochrome P450 for this pathway of metabolism are the isoenzyme CYP2E1 (predominantly), CYP1A2 and CYP3A4 (secondary role). With glutathione deficiency, these metabolites can also cause necroshepatocyte damage. Additional metabolic pathways include hydroxylation of 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated paracetamol metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. It is excreted by the kidneys as metabolites, mainly conjugates, only 3% unchanged. In elderly patients, the clearance of the drug decreases and the elimination half-life increases.
The maximum concentration (Cmax) of paracetamol in blood plasma is achieved when capsules are used after 1.20 ± 0.72 h and is 5.01 ± 1.70 μg / ml, the half-life (T1 / 2) is 3.04 ± 1, 01 h
Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Communication with plasma proteins - 25%. Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestines. The concentration of ascorbic acid in blood plasma is normally approximately 10-20 μg / ml. The time of maximum concentration in blood plasma after ingestion is 4 hours. It easily penetrates into white blood cells, platelets, and then into all tissues, the highest concentration is reached in glandular organs, white blood cells, liver and lens of the eye penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in red blood cells and in plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration. It is metabolized mainly in the liver to deoxy-ascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, through the sweat glands in an unchanged form and in the form of metabolites. Smoking and the use of ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), drastically reducing body reserves. It is excreted during hemodialysis.
Calcium gluconate. About 1 / 5-1 / 3 of the orally administered calcium gluconate is absorbed in the small intestine, this process depends on the presence of ergocalciferol, pH, dietary features and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) - by the intestine.
rimantadine. After oral administration, it is almost completely absorbed in the intestine. Absorption is slow. Communication with plasma proteins - about 40%. Distribution volume - 17-25 l / kg. Concentration in nasal secretion is 50% higher than plasma. Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged. In chronic renal failure, T1 / 2 increases by 2 times. In persons with renal failure and in the elderly, it may accumulate in toxic concentrations if the dose is not adjusted in proportion to a decrease in creatinine clearance. Hemodialysis has an insignificant effect on the clearance of rimantadine.
Cmaxrimantadine in blood plasma is achieved with capsules after 4.53 ± 2.52 hours and is 68.2 ± 26.6 ng / ml, T1 / 2-30.51 ± 9.83 hours.
Rutoside. The time of maximum concentration in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and to a lesser extent by the kidneys. T1 / 2— 10-25 h.
loratadine. Quickly and completely absorbed in the gastrointestinal tract. The maximum concentration in the elderly increases by 50%. Communication with plasma proteins - 97%. It is metabolized in the liver with the formation of the active metabolite of decarboethoxyloratadine with the participation of cytochrome CYP3A4 isoenzymes and to a lesser extent CYP2D6. Does not cross the blood-brain barrier. It is excreted by the kidneys and with bile. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics are practically unchanged.
Cmaxloratadine in blood plasma is reached after 2.92 ± 1.31 h and is 2.36 ± 1.53 ng / ml, T1 / 2-12.36 ± 6.84 h.
Indications
Treatment of type A flu, symptomatic treatment of colds, flu and SARS, accompanied by fever, chills, nasal congestion, sore throat, pain in joints and muscles, headache.
Contraindications
Hypersensitivity to one or more components, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase gastrointestinal bleeding hemophilia hemorrhagic diathesis hypoprothrombinemia portal hypertension avitaminosis K renal failure pregnancy, period of breastfeeding thyroid disease, acute kidney disease, liver disease (acute glomerulone acute hepatitis, or exacerbation of chronic diseases of these organs) chronic alcoholism hypercalcemia, pronounced hypercalcium Uriah nefrourolitiaz, sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias), lactose intolerance, lactase deficiency, glucose-galaktoznayamalabsorbtsiya.
Children under 18 years old.
Precautions
Limitation of use for epilepsy, cerebral atherosclerosis, diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, kidney stone disease, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (anemia).
Elderly patients with arterial hypertension (increased risk of hemorrhagic stroke due to rimantadine, which is part of the drug).
Special instructions
Duration of use - no more than 5 days.
It is necessary to carry out laboratory monitoring of blood counts.
Do not use if metastatic tumors are present.
Persons prone to ethanol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.
Effect on the ability to drive vehicles and other mechanisms requiring increased concentration of attention
Given the possible development of side effects (dizziness, drowsiness) during the treatment period, it is not recommended to drive vehicles and engage in other activities that require increased concentration of attention and high speed psychomotor reactions.
Compound sachet-action: 9 mg capsule 30 mg capsule , colloidal silicon dioxide 3 mg, lactose monohydrate 1.2 mg, magnesium stearate 3.8 mg, polysorbate 803 mg. The composition of the hard gelatin capsule: gelatin - 94.795 mg, patent blue dye (E 131) or diamond blue dye (E 133) - 0.265 mg, titanium dioxide (E 171) - 1.94 mg.
Capsule R. Active ingredients: ascorbic acid - 300 mg, calcium gluconate monohydrate - 100 mg, rimantadine hydrochloride - 50 mg, rutosidate trihydrate (in terms of rutoside) - 20 mg, loratadine - 3 mg excipients: potato starch - 2.2 mg, magnesium stearate - 4.8 mg. The composition of the hard gelatin capsule: gelatin - 94.064 mg, iron oxide dye yellow (E 172) - 0.97 mg, iron oxide red oxide (E 172) - 0.485 mg, crimson dye [Ponceau 4R] (E 124) - 0.511 mg, titanium dioxide (E 171) - 0.97 mg.
Dosage and Administration
Inside.
Adults: 1 capsule P of blue color and 1 capsule P of red color (single dose) 2-3 times
a day after meals with water. The interval between doses of the drug is 4-6 hours. Therapy course for the disappearance of the symptoms of the disease. AnviMax® should not be taken for more than 5 days. If symptom relief is not observed within 3 days after starting the drug, you should consult a doctor.
Side effects
Possible unwanted side reactions are indicated in accordance with the constituents.
From the central nervous system: increased irritability, drowsiness, tremors, hyperkinesia, dizziness, headache, flushing of the face.
From the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).
From the urinary system: moderate pollakiuria.
From the hemopoietic organs: changes in blood counts.
Allergic reactions: angioedema, anaphylactic shock, skin rash, itching, urticaria.
From the skin: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome) and acute generalized exanthematous pustulosis.
Other: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).
Experience with post-registration use of
During the use of the drug AnviMax®, cases of angioedema, fainting, fever, decreased blood pressure, urticaria, skin itching, erythema, hearing impairment, and sore throat were described.
If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor immediately.
Drug Interactions
Paracetamol reduces the effectiveness of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose. With simultaneous use with metoclopramide, an increase in the rate of absorption of paracetamol is possible. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.
Rimantadinus enhances the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.
Ascorbic acid increases the concentration of benzylpenicillin in the blood. It improves the absorption of iron preparations in the intestines (converts ferric to ferrous) and can increase iron excretion while used with deferoxamine. Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acids by the kidneys, increases the excretion of drugs having an alkaline reaction (including alkaloids). Reduces the blood concentration of oral contraceptives. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. With simultaneous use, it reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase urinary excretion of ascorbic acid. Reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
loratadine. CYP3A4 and CYP2D6 inhibitors increase the concentration of blood loratadine.
Overdose
Symptoms: within the first 24 hours after ingestion - pale skin, nausea, diarrhea, vomiting, epigastric pain, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation. Symptoms of liver dysfunction may occur 12-48 hours after overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma acute renal failure with tubular necrosis (including in the absence of severe liver damage).
Treatment: administration of SH-group donors and precursors for glutathione-methionine synthesis within 8-9 h after overdose and acetylcysteine for 8 h. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as by the time that has elapsed after its administration.
Storage conditions
In a dry place, at a temperature not exceeding 25 ° C.
Keep out of the reach and sight of children.
Shelf life
2 years.
Active ingredients about
Paracetamol, Ascorbic Acid, Rimantadine, Rutoside, Loratadine, Kalytsiya gluconate
Terms and conditions
without prescription
dosage form
capsules
Appointment
Appointment
Adult
Farmtsentr VILAR SA, Russia
AnviMax capsules, 20 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate) florida in pharmacy online. Cheap price, instruction, side effects, dosage. AnviMax capsules, 20 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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