Arlet tablets 625 mg, 14 pcs. (Amoxicillin, clavulanic acid)

Release form

Film-coated tablets.



packaging 14 pcs

Pharmacological action of

Arlet is a combination of amoxicillin (semisynthetic penicillin with a wide spectrum of antibacterial activity and clavulanic acid (an irreversible inhibitor of -lactamase). Clavulanic acid forms a stable inactivated complex with the indicated enzymes-organisms and microorganism enzymes аз and microorganism-resistance

Clavulanic acid, similar in structure to -lactam antibiotics, has a weak intrinsic antibiotic .

Arlete ble activity has a broad spectrum of antibacterial action is active against susceptible to amoxicillin strains, including strains producing lactamase: -. Gram-positive aerobes: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (except for methicillin-resistant strains), Staphylococcus epidermidis (except for methicillin-resistant strains), Staphylococcus saprophyticus, Listeria spp., Enteroccocus spp.

- gram-negative aerobes: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Molexelis pleissa neppelissa neraissa neppelissa neppelissa neppelissa neppelissa neppelissa neppelidae , Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens

- gram-positive anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii Fppobus.

- gram-negative anaerobes: Bacteroides spp.

Indications

Infections caused by susceptible strains of microorganisms:

- infections of the upper respiratory tract and ENT organs (acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis)

- lower respiratory tract infections (acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia)

- urinary tract infections

- gynecological infections

- skin and soft tissue infections

- bone and connective tissue infections srd (cholecystitis, cholangitis)

- odontogenic infections.

Contraindications

Hypersensitivity (including to cephalosporins and other beta-lactam antibiotics), infectious mononucleosis (including with the appearance of a measles-like rash), children's age up to 3 years (for this lek. form).

With caution - pregnancy, lactation, severe liver failure, diseases of the gastrointestinal tract (including a history of colitis associated with the use of penicillins), chronic renal failure.

Use during pregnancy and lactation

Arlet can be prescribed - during pregnancy only in cases where the expected benefits to the mother outweigh the potential risk to the fetus.

Amoxicillin and clavulanic acid in small quantities pass into breast milk, therefore, if necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Composition

1 tablet contains amoxicillin trihydrate 500 mg, clavulanic acid 125 mg

excipients: polyvinylpyrrolidone (povidone), talc (magnesium hydrosilicate), starch 1500, calcium stearic acid (calcium steroic acid, calcium steroic acid) .

shell composition: hypromellose (hydroxypropyl methylcellulose), propylene glycol, titanium dioxide, polyethylene oxide 4000 (macrogol 4000).

Dosage and administration of

Arlet taken orally. Adults and children over 12 years old (or with a body weight> 40 kg) for mild or moderate infections - 1 table. Arlet 500/125 mg every 12 hours, in case of severe infection and respiratory tract infections - 1 table. 500/125 mg every 8 hours

Side effects

From the digestive system: loss of appetite, nausea, vomiting, diarrhea rarely - impaired liver function, increased activity of alanine aminotransferase (ALT) or aspartic aminotransferase (ACT) in isolated cases - cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: itching, urticaria, erythematous rashes rarely - multiforme exudative erythema, angioedema, anaphylactic shock in isolated cases - exfoliative dermatitis, Stevens-Johnson syndrome.

From the hematopoietic system: a reversible increase in prothrombin time, leukopenia, reversible agranulocytosis and hemolytic anemia.

From the central nervous system: dizziness, headache, reversible hyperactivity and cramps.

From the kidneys and urinary tract: interstitial nephritis, crystalluria.

Other: candidiasis and other types of superinfection.

Drug Interaction

Co-administration with methotrexate increases the toxicity of methotrexate. The appointment with allopurinol increases the incidence of exanthema. Antacids, glucosamine, laxatives, aminoglycosides - slow down and reduce absorption ascorbic acid increases absorption. Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic. Improves the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reducing vitamin K synthesis and prothrombin index). When co-administered with anticoagulants, blood clotting should be monitored. Reduces the effectiveness of oral contraceptives, medicines in the process of metabolism of which is formed paraaminobenzoic acid, ethinyl estradiol - the risk of breakthrough bleeding. Diuretics, allopurinol, phenylbutazone, non-steroidal anti-inflammatory drugs, and other drugs that block tubular secretion, increase the concentration of amoxicillin (clavulanic acid is eliminated mainly by glomerular filtration).

overdose

In most cases, symptoms of overdose include disorders of the gastrointestinal tract (abdominal pain, diarrhea, vomiting), also possible anxiety, insomnia, dizziness, in isolated cases. At overdose the patient should be under the supervision of a doctor, treatment is symptomatic.

In case of a recent intake (less than 4 hours), gastric lavage and activated charcoal should be performed to reduce suction. Amoxicillin / clavulanate potassium is removed by hemodialysis.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Expiration

2 years.

Active ingredient

amoxicillin, Clavulanic acid

dosage form

dosage form

tablets

Sintez AKOMP, Russia



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