Ascorbic acid ampoules 5%, 2 ml, 10 pcs. (Askorbynovaya kyslota)

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Release form

Injection.

Packing

10 amp. 2 ml each.

Pharmacological action

Vitamin C. Ascorbic acid is necessary for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones and capillary walls. Participates in redox reactions, tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, lipid and protein synthesis, iron metabolism, cellular respiration processes, activates the synthesis of steroid hormones. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, helps to increase the body's resistance to infections, improves the absorption of iron, contributing to its deposition in a reduced form. It has antioxidant properties.

With intravaginal administration, ascorbic acid lowers the vaginal pH by inhibiting bacterial growth and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).

Indications

Used for prophylactic and therapeutic purposes in all clinical situations associated with the need for additional administration of vitamin C. It is prescribed for the prevention and treatment of scurvy, with bleeding (nasal, pulmonary, uterine, caused by radiation sickness), hemorrhagic diathesis, with various intoxications and infectious diseases, nephropathy of pregnant women, Addison's disease, with an overdose of anticoagulants, bone fractures and sluggish wounds, various dystrophies, with increased mental stress strain and enhanced physical labor.

Contraindications

Hypersensitivity, with prolonged use in large doses (more than 500 mg) - diabetes, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

Precautions

Sideroblastic anemia, urolithiasis.

Use during pregnancy and lactation

During pregnancy and lactation, use only if the intended benefit to the mother outweighs the potential risk to the fetus and baby. The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then the withdrawal syndrome may develop in the newborn. The minimum daily need for lactation is 80 mg. A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent a baby’s deficiency. Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily requirement for ascorbic acid by the nursing mother).

Special instructions

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure. High doses of ascorbic acid enhance the excretion of oxalates, contributing to the formation of kidney stones. In newborns whose mothers took high doses of ascorbic acid, and in adults who took high doses, ricochet scurvy can be observed. With prolonged use of large doses, inhibition of the function of the insular apparatus of the pancreas is possible, therefore, during treatment, it must be regularly monitored. In patients with a high iron content in the body, ascorbic acid should be used in minimal doses. As a reducing agent, ascorbic acid can distort the results of various laboratory tests (the content of glucose, bilirubin, the activity of hepatic transaminases and lactate dehydrogenase in the blood and urine).

Influence on the ability to drive vehicles and control mechanisms

During the treatment period, care must be taken when driving and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Composition

Active ingredient: ascorbic acid 50 mg.

Excipients: sodium bicarbonate (sodium bicarbonate) 23.85 mg or 47.7 mg, sodium sulfite (sodium sulfite) 2 mg or 2 mg, water for injection, saturated with carbon dioxide up to 1 ml.

Dosage and administration

Used as directed by a physician. Ascorbic acid is prescribed orally (after eating), intramuscularly or intravenously. For preventive purposes, adults are prescribed 0.05 g-0.1 g per day during pregnancy, in the postpartum period and in the case of a low content of vitamin C in the milk of nursing women, 0 is prescribed. 3 g per day for 10-15 days, after which prophylactically 0.1 g per day for the entire lactation period. Children are prescribed prophylactically at 0.025 g 2-3 times a day. Therapeutic doses for adults are, when taken orally, - 05-0.1 g 3-5 times a day for children - 0.05-0.1 g 2-3 times a day. Therapeutic dose for adults with parenteral administration is 1-3 ml of a 5% solution (2-6 ml of a 2.5% solution) per day. Children are prescribed parenterally 1-2 ml of a 5% solution (2-4 ml of a 2.5% solution) per day.

The course of treatment depends on the nature and course of the disease.

Side effects

From the side of the central nervous system: with rapid intravenous administration - dizziness, feeling tired, with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when applying a dose of more than 600 mg / day), with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.

From the cardiovascular system: with prolonged use of large doses, a decrease in capillary permeability (possibly worsening tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Allergic reactions: allergic reactions up to the development of anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria.

Local reactions: pain at the site of intramuscular injection.

Other: with prolonged use of large doses (more than 1 g) - inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria), with intravenous administration - the threat of abortion (due to estrogenemia), erythrocyte hemolysis.

Drug Interactions

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicin.

Increases the concentration in the blood of benzylpenicillin and tetracyclines at a dose of 1 g / day, increases the bioavailability of ethinyl estradiol (including that which is part of oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and excretion of acetylsalicylic acid decreases.

Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Quinoline drugs, calcium preparations, salicylates, glucocorticosteroids, with prolonged use, deplete ascorbic acid reserves.

With simultaneous use, it reduces the chronotropic effect of isoprenaline.

Long-term or high-dose use may interfere with the interaction of disulfiram and ethanol. In high doses, it increases the excretion of mexiletine by the kidneys. Barbiturates and primidone increase urinary excretion of ascorbic acid.

Reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

Storage conditions

In a protected place from light at a temperature not exceeding 15 ° C

Expiration

1 year.

active substance

Ascorbic kislota

Terms leave through pharmacies

More prescription

lekarstvennaja form

Solution for and infusions

Indications

Inadequate nutrition, From infectious diseases, Varicose veins, From bleeding, From bone fractures

Possible product names

Ascorbic acid ampoules 5%, 2 ml, 10 pcs.

Russia, Russia, Russia biosynthesis



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