Ascorbic acid twist tablets 25 mg, 10 pcs. (Askorbynovaya kyslota)

Release form

Tablets.

Packing

Per pack 10 pcs.

Pharmacological action of

Ascorbic acid has pronounced reducing properties, is involved in the regulation of carbohydrate metabolism, redox processes, blood coagulation, normalization of capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.

Indications

Used for prophylactic and therapeutic purposes in all clinical situations associated with the need for additional administration of vitamin C. It is prescribed for the prevention and treatment of scurvy, with bleeding (nasal, pulmonary, uterine, caused by radiation sickness), hemorrhagic diathesis, with various intoxications and infectious diseases, pregnant nephropathy, Addison's disease, with an overdose of anticoagulants, bone fractures and sluggish wounds, various dystrophies, with increased mental stress and increased physical labor.

Contraindications

Hypersensitivity, with prolonged use in large doses (more than 500 mg) - diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

Precautions

Sideroblastic anemia, urolithiasis.

Use during pregnancy and lactation

During pregnancy and lactation, use only if the intended benefit to the mother outweighs the potential risk to the fetus and baby. The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. Keep in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a withdrawal syndrome may develop in the newborn. The minimum daily need for lactation is 80 mg. A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent a baby’s deficiency. Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily requirement for ascorbic acid by the nursing mother).

Special instructions

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure. High doses of ascorbic acid enhance the excretion of oxalates, contributing to the formation of kidney stones. In newborns, mothers who took high doses of ascorbic acid, and adults who took high doses, may experience rebound scurvy. With prolonged use of large doses, inhibition of the function of the insular apparatus of the pancreas is possible, therefore, during treatment it must be regularly monitored. In patients with a high iron content in the body, ascorbic acid should be used in minimal doses. As a reducing agent, ascorbic acid can distort the results of various laboratory tests (the content of glucose, bilirubin, the activity of hepatic transaminases and lactate dehydrogenase in the blood and urine).

Influence on the ability to drive vehicles and control mechanisms

During the treatment period, care must be taken when driving and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Composition

1 tablet contains 25 mg ascorbic acid.

Dosage and administration of

For preventive purposes for adults - at 0.05-0, 1 g per day during pregnancy, in the postpartum period and in the case of a low content of vitamin C in the milk of nursing women - 0.3 g per day for 10-15 days, after which prophylactically - 0.1 g per day for the entire lactation period. Children for prevention - 0.025 g 2-3 times a day. Therapeutic doses for adults are 0.05-0.1 g 3-5 times a day. Children - 0.05-0.1 g 2-3 times a day.

Side effects

From the central nervous system: with rapid intravenous administration - dizziness, feeling tired, with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when applying a dose of more than 600 mg / day), with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.

From the cardiovascular system: with prolonged use of large doses, a decrease in capillary permeability (possibly worsening tissue trophism, increased blood pressure, hypercoagulation, the development of microangiopathies).

Allergic reactions: allergic reactions up to the development of anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria.

Drug Interactions

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicin.

Increases the concentration in the blood of benzylpenicillin and tetracyclines at a dose of 1 g / day, increases the bioavailability of ethinyl estradiol (including that which is part of oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and excretion of acetylsalicylic acid decreases.

Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Quinoline drugs, calcium preparations, salicylates, glucocorticosteroids, with prolonged use, deplete ascorbic acid reserves.

With simultaneous use, it reduces the chronotropic effect of isoprenaline.

Long-term or high-dose use may interfere with the interaction of disulfiram and ethanol. In high doses, it increases the excretion of mexiletine by the kidneys. Barbiturates and primidone increase urinary excretion of ascorbic acid.

Reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Storage conditions

In a dark place at a temperature not exceeding 15 ° С

Deystvuyuschee substances

Askorbynovaya kyslota

Terms and conditions

without prescription

dosage form

tablets

Indications

Colds, From hypovitaminosis, Insufficient nutrition, Flu, From infectious diseases, In intense physical activity, From stress, During recovery

Marbiopharm, Russia



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