Asparkam-L ampoules of 10 ml, 10 pieces. (potassium and magnesium asparahynat)

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Release form

Solution for intravenous administration Buy Asparkam-L ampoules of 10 ml, 10 pieces. (potassium and magnesium asparahynat) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form

Solution for intravenous administration

Packing

10 ampoules of 10 ml.

Pharmacological action

Elimination of potassium and magnesium deficiency, normalization of electrolyte balance, improved metabolism in the myocardium. The mechanism of action of the drug is associated with the effective participation of L-asparaginate in the transport of magnesium and potassium ions into the intracellular space.

Magnesium activates sodium-potassium-ATPase, Removing sodium ions from the cell and returning potassium ions reduces the sodium content and prevents its exchange for calcium in the smooth muscles of blood vessels, lowering their resistance. Potassium stimulates the synthesis of adenosine triphosphate, glycogen, proteins, acetylcholine, etc. Both ions support polarization / cell membranes. The drug regulates the conduction of impulses along nerve fibers, synaptic transmission, muscle contraction, and the work of the heart muscle. Due to magnesium ions, it participates in the processes of energy input and expenditure, normalizes membrane permeability, neuromuscular conductivity, synthesis of deoxyribonucleic and ribonucleic acids, cell growth, cell division, oxygen uptake, and phosphate synthesis.

Indications

To eliminate potassium and magnesium deficiency as an adjuvant in various manifestations of coronary heart disease, including acute myocardial infarction, chronic circulatory failure, cardiac arrhythmias (arrhythmias caused by overdose of cardiac glycosides).

Contraindications

Hypersensitivity to the drug, sorbitol, hyperkalemia, hypermagnesemia, acute and chronic renal failure, adrenal cortex insufficiency, atrioventricular block II and III degree, cardiogenic shock, oliguria, anauria, anauria, myasthenia syndrome , arterial hypotension, pregnancy, lactation, age up to 18 years (efficacy and safety have not been established).

Specific guidelines

No studies have been conducted to evaluate the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Composition

Active ingredients: potassium L-asparaginate anhydrous - 45.20 g (10.33 g of potassium), magnesium L-asparaginate anhydrous - 40.00 g (3, 37 g of magnesium) obtained according to the following recipe: L-aspartic acid - 74.00 g, potassium hydroxide (potassium hydroxide) - 14.82 g, magnesium oxide - 5.59 g

Excipients: sorbitol (sorbitol) - 50, 00 g, water for injection - up to 1 liter.

Dosage and administration

The drug is administered intravenously (drip or stream). The dose of the drug is determined individually depending on the indications for use. Intravenous drip is administered at a rate of 25 drops in 1 minute 1-2 times a day, 10 to 20 ml (1-2 ampoules of 10 ml or 2-4 ampoules of 5 ml), diluted in 100-200 ml of isotonic sodium chloride solution or 5% glucose solution. When injected, the contents of 1 ampoule of 10 ml or 2 ampoules of 5 ml are diluted in 20 ml of sterile water for injection or 5% glucose solution and injected slowly (not more than 5 ml per minute) into a vein.

Side effects

Nausea, dizziness, facial flushing, thirst, low blood pressure, hyporeflexia are possible. Phenomena usually disappear with a decrease in the dose of the drug.

With rapid intravenous administration, all symptoms of hyperkalemia and hypermagnesemia may appear.

Hyperkalemia (nausea, vomiting, diarrhea, paresthesia) and hypermagnesemia (hyperemia of the skin of the face, thirst, bradycardia, decreased blood pressure, muscle weakness, fatigue, paresis, coma, areflexia, respiratory depression, convulsions) with parenteral parenteral administration - reaction (increase in the number of extrasystoles), phlebitis.

Drug interaction

Potassium-sparing diuretics (triamteren, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs - the risk of developing hyperkalemia and asolitis.

Eliminates hypokalemia caused by glucocorticosteroids.

Reduces unwanted effects of cardiac glycosides.

Due to the content of magnesium ions it reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.

May enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracuria besylate, decametonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the concentration of magnesium in blood plasma, calcium preparations - reduce the effect of magnesium.

The solution is pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerance).

Storage conditions

At a temperature of 0 to 25 ° C.

Term hodnosty

2 years

Active ingredient

Potassium and magnesium asparaginate



pharmacy terms and conditions for prescription

Form of Treatment

simply entails dlya infusing

Appointment

for Adults on the appointment of doctor Appointment

Indications

Heart rhythm disturbances, Heart failure, Coronary heart disease, Potassium and magnesium deficiency, Arrhythmia, Acute heart attack myocardium, Prevention of acute myocardial infarction, myocardial infarction

Possible product names

Asparkam-L ampoules 10 ml, 10 pcs.

Russia, Russia, Russia biosynthesis



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