Azitral capsules 250 mg, 6 pcs. (Azithromycin)

Release form

Capsules

Packing

6 pcs.

Pharmacological action

Azitral is a broad-spectrum antibiotic. It is a representative of the subgroup of macrolide antibiotics - azalides. When creating high concentrations of inflammation in the focus, it has a bactericidal effect.

Gram-positive cocci are sensitive to azithromycin: Streptococcus pneumoniae, St. pyogenes, St. agalactiae, streptococci of CF and G groups, Staphylococcus aureus, St. viridans Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. educrei, Campylobacter jejuni, Helicobacter Pylori, Neisseria bacteriochemidaeffinalidae gonorrhoeae, and microorganisms of the bacterial trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycin is inactive against gram-positive bacteria resistant to erythromycin.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

Upper respiratory tract and ENT organs infections (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media)

Scarlet fever pneumonia and lower respiratory infections , bronchitis)

Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses)

Urogenital tract infections (gonorrheal and non-chronic urethritis and / or cervicitis)

Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans)

Disease of the stomach and duodenum associated with combination therapy (Heloriobacter) .

Contraindications

Hypersensitivity (including other macrolides), liver and / or renal failure, lactation.

Precautions - pregnancy (can be used in cases where the benefits of its use significantly exceed the risk that always exists when using any drug during nnosti), arrhythmia (ventricular fibrillation and lengthening the interval QT), children up to 16 years (w / w, tablets, capsules), children with severe liver or kidney function, neonates (oral suspension).

Special instructions

A 2-hour break must be observed while antacids are used.

After withdrawal of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under the supervision of a physician.

Ingredients

1 capsule contains azithromycin 250 mg

excipients: lactose anhydrous, corn starch, magnesium stearate, sodium lauryl sulfate

Dosage and administration

Inside, 1 hour before or 2 hours after eating, 1 time per day.

Adults with infections of the upper and lower respiratory tract - 0.5 g / day for 1 dose for 3 days (course dose - 1.5 g).

For infections of the skin and soft tissues - 1 g / day on the first day for 1 dose, then 0.5 g / day daily from 2 to 5 days (course dose - 3 g).

In acute infections of the genitourinary organs (uncomplicated urethritis or cervicitis) - once 1 g.

For Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) - 1 g on the first day and 0.5 g daily from 2 to 5 days (course dose - 3 g). In case of peptic ulcer of the stomach and duodenum associated with Helicobacter pylori - 1 g / day for 3 days as part of combination anti-Helicobacter therapy.

Children are prescribed at a rate of 10 mg / kg once a day for 3 days or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg / day for 3 days (course dose - 30 mg / kg).

In the treatment of erythema migrans in children, the dose is 20 mg / kg on the first day and 10 mg / kg from day 2 to 5. In / in, in the treatment of pneumonia - 0.5 g once, for at least 2 days, subsequently inside, 2 capsules (0.25 g each) course - 7-10 days.

In case of pelvic infections - iv, 0.5 g once, subsequently inside, 2 capsules (0.25 g each) course - 7 days.

Side effects of the digestive system: when taken orally - diarrhea (5%), nausea (3%), abdominal pain (3%) 1% or less - dyspepsia, flatulence, vomiting, melena, cholestatic jaundice, increased activity hepatic transaminases in addition, in children - constipation, anorexia, gastritis candidiasis of the oral mucosa (with iv administration). From the CCC: palpitations, chest pain (1% or less).

From the nervous system: dizziness, headache, vertigo, drowsiness in children - headache (with treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less).

From the genitourinary system: vaginal candidiasis, nephritis (1% or less).

Allergic reactions: rash, photosensitivity, Quincke's edema with iv administration - bronchospasm (1% or less).

Other: increased fatigue in children - conjunctivitis, pruritus, urticaria with iv administration - a change in taste (1% or less).

Drug interactions

Antacids (aluminum and magnesium), ethanol and food slow down and reduce absorption. With the combined use of warfarin and azithromycin (in usual doses), changes in prothrombin time were not detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulation effect, patients need careful monitoring of prothrombin time. Digoxin: increased digoxin concentration. Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia). Triazolam: decreased clearance and increased pharmacological effect of triazolan. Slows down the excretion and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs subjected to microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine phenytoin, phenytoin, oral hypoglycemic agents, theophylline and other xanthine derivatives) - due to the inhibition of microsomal oxidation in hepatocytes azite. Lincosamines weaken effectiveness, tetracycline and chloramphenicol enhance. Pharmaceutically incompatible with heparin.

Overdose

Symptoms: severe nausea, temporary hearing loss, vomiting, diarrhea.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.

The Expiration of

is 3 years.

Active substance

Azithromycin

Terms leave through pharmacies

In retseptu

lekarstvennaja form

kapsul

Prescription

For pregnant women prescribed by a doctor, Adults prescribed by a doctor, Children over 12 years old

Indications

Indications

Bronchitis, Otitis, Pharyngitis, Skin infections, Sore throat, Respiratory tract infections, Urethritis Infectious e disease, sinusitis, tonsillitis, Pneumonia, Cystitis



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