bacitracin, neomycin (bacitracin, neomycin)

Release form

Powder for external use.

Packaging

dispensing bottle 10 g

Pharmacological action

Baneocin is a combined antibacterial drug for external use. It contains two antibiotics that have a bactericidal effect, neomycin and bacitracin.

Bacitracin is a polypeptide antibiotic that inhibits bacterial cell wall synthesis.

Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis.

Bacitracin is active against gram-positive (Streptococcus spp. / including hemolytic streptococcus /, Staphylococcus spp. ) and some gram-negative microorganisms. Bacitracin resistance is rare. It has good tissue tolerance of inactivation by biological products, blood and tissue components are not observed.

Neomycin is active against gram-positive and gram-negative bacteria.

By using a combination of these two antibiotics, a broad spectrum of action of the drug and synergy of action against a number of microorganisms, for example, staphylococci, are achieved.

Indications

- Bacterial skin infections of limited prevalence, for example bacterial infections with Herpes simplex and Herpes zoster / or with varicella vesicles, weeping contagious impetigo, infected varicose ulcers, eczema infected, bacterial diaper dermatitis.

- Prevention of umbilical infection in newborns

- After surgical (dermatological) procedures

Baneocin powder can be used for additional treatment in the postoperative period (excision and cauterization, treatment of cracks, ruptures of the perineum and episiotomy, wet wounds and abrasions.

Contraindications

History of hypersensitivity to bacitracin and / or neomycin, or to other aminoglycoside antibiotics.

Baneocin should not be used for significant skin lesions, since absorption of the drug can cause an ototoxic effect with hearing loss.

Baneocin should not be used in patients with severe impaired excretory function, including renal etiology and already having lesions of the vestibular and cochlear systems, in cases where uncontrolled absorption of the drug is possible.

Do not use in the external auditory canal when perforating the eardrum.

Do not apply on eyes.

Use during pregnancy and lactation

In cases where it is not possible to control the absorption of the drug in pregnant and lactating women, Baneocin should be used with caution. Like all other aminoglycosides, neomycin crosses the placental barrier. With the systemic use of aminoglycosides in a high dose, the development of damage to the cochlear apparatus in the fetus was noted.

Composition

1 g contains Zinc-Bacitracin 250 IU, Neomycin sulfate 5000 IU (5 mg).

Dosage and administration

Apply the necessary amount of ointment or powder to the treatment site, if appropriate, under a dressing.

As a rule, in adults and children Baneocin powder is used two to four times a day, while Baneocin ointment is used two to three times a day.

In patients with burns occupying more than 20% of the body surface, Baneocin powder should not be used more than once a day, especially in case of decreased renal function, since there may be absorption of the active ingredient.

When applied topically, the dose of neomycin should not exceed 1 g per day (corresponding to 200 g of powder or ointment) for 7 days. With a repeated course, the maximum dose should be halved.

Side effects

Allergic reactions: with prolonged use - redness, dry skin, skin rash, itching. In the treatment of chronic dermatoses or chronic otitis media, Baneocin promotes sensitization to other drugs, including neomycin. This may result in poor treatment effectiveness. Allergic reactions of the type of contact eczema were less common than usual (associated with cross-allergy to other aminoglycosides in approximately 50% of cases).

Systemic effects: for extensive skin lesions, the possibility of drug absorption and the development of oto- and nephrotoxic effects and neuromuscular conduction disorders should be taken into account.

Drug Interactions

If systemic absorption occurs, concomitant administration of cephalosporins or other aminoglycoside antibiotics may increase the likelihood of a nephrotoxic reaction.

The simultaneous use of diuretics such as ethacrylic acid or furosemide can provoke an oto- and nephrotoxic effect.

Baneocin absorption may potentiate neuromuscular block phenomena in patients receiving drugs, anesthetics, and muscle relaxants.

Storage conditions

Store below 25 ° C in a dark place. The powder should be stored in a dry place.

Expiration

3 years.

Active ingredient sr dlkp bacitracin, neomycin

Pharmacy conditions

without prescription

lekarstvennaja form

powder naruzhnej Application

Prescription

Nursing mothers as prescribed by a doctor, For adults, Pregnant as prescribed by a doctor, Children as prescribed by a doctor

Indications

Indications

Minor skin lesions, Boils, Skin infections, Trophic ulcers

sandoz, switzerland



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