Baralgin M tablets 100 pcs. (metamizol sodium)

Packing

100 pcs.

Pharmacological action

Baralgin M - NSAIDs, a derivative of pyrazolone, practically does not differ from other NSAIDs in its mechanism of action (blocks COX and reduces the formation of Pg from arachidonic acid).

Prevents painful extra- and proprioreceptive impulses from the Gaulle and Burdach beams, raises the threshold of excitability of the thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

Has analgesic, antipyretic and pronounced antispasmodic (on smooth muscles of the urinary and biliary tract) action.

The action develops after 20-40 minutes and reaches a maximum after 2 hours.

Indications

mild to moderate pain syndrome (headache, toothache, neuralgia, pain with radiculitis, osteochondrosis, arthritis, menalgia),

smooth muscle spasms (renal colic, biliary colic, intestinal colic),

fever in infectious and inflammatory diseases (as part of combination therapy).

Contraindications

hypersensitivity,

inhibition of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia),

hepatic and / or renal failure,

hereditary hemolytic anemia, spermatozoa, 6

Use during pregnancy and lactation

Contraindicated in the first and third trimesters of pregnancy.

Use in the II trimester - only for strict medical reasons.

Breastfeeding is contraindicated for 48 hours after taking Baralgin M.

Composition

1 tablet contains:

Active ingredient: metamizole sodium 500 mg

Excipients: macrogol 4000 47 mg, magnesium stearate 3 mg.

Dosage and administration

Inside, 250-500 mg 2-3 times a day, the maximum single dose - 1 g, daily - 3 g.

Single doses for children 2-3 years old - 50-100 mg, 4-5 years old - 100-200 mg, 6-7 years old - 200 mg, 8-14 years old - 250-300 mg, frequency of administration - 2-3 times per day.

Children are prescribed at a rate of 5-10 mg / kg 2-3 times a day.

Side effects of

From the urinary system: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, staining of urine in red.

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), Quincke's edema, in rare cases - malignant exudative erythema (Stevens-J syndrome

onson), toxic epidermal necrolysis (Lyell syndrome), bronchospasm shock.

From the side of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: decrease in blood pressure.

Local reactions: with i / m administration, infiltrates at the injection site are possible.

Drug Interaction

Enhances the effects of ethanol when used concomitantly with chlorpromazine or the like. phenothiazine derivatives can lead to the development of marked hyperthermia.

X-ray contrast agents, colloidal blood substitutes and penicillin should not be used during metamizole treatment. With the simultaneous appointment of cyclosporine decreases the concentration of the latter in the blood. Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, ACS, and indomethacin from the protein association, increases their activity.

Phenylbutazone, barbiturates, and other hepatoinducers at the same time reduce the effectiveness of metamizole.

Concurrent administration with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormones and allopurinol may lead to increased toxicity.

Sedatives and tranquilizers enhance the analgesic effect of metamizole.

Thiamazole and sarcolysin increase the risk of leukopenia.

The effect is enhanced by codeine, histamine H2 blockers and propranolol (slows down inactivation).

Overdose

In case of overdose, consult your doctor.

The following symptoms may occur: nausea, vomiting, stomach pain, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, hemorrhagic syndrome, , respiratory muscle paralysis.

Treatment: cause vomiting, gastric lavage through a probe salt laxatives, activated charcoal conducting forced diuresis, hemodialysis in the development of convulsive syndrome - intravenous injection of diazepam and high-speed barbiturates.

Storage conditions

In a dark place at a temperature of 8–25 ° C

Expiration

4 years.

Deystvuyuschee substance

Metamizole sodium

dosage form

dosage form

tablets

Sanofi-Aventis, France



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