Betaver tablets 16 mg, 30 pcs. (betahistine)

Release form

Tablets.



packaging 30 pcs

Pharmacological action

Betaver is a synthetic analogue of histamine.

Pharmacodynamics

Betagistin acts mainly on the histamine H1 and H3 receptors of the inner ear and vestibular nuclei of the central nervous system. By direct agonistic action on the H1 receptors of the vessels of the inner ear, and also indirectly through exposure to H3 receptors it improves microcirculation and permeability of capillaries of the inner ear, normalizes the pressure of the endolymph in the labyrinth and cochlea. However, betahistine increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of the H3 receptors of the vestibular nerve nuclei. Normalizes the conductivity in neurons of the vestibular nuclei at the level of the brain stem.

The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in tinnitus, and an improvement in hearing if it is reduced.

Pharmacokinetics

Absorbed rapidly, binding to plasma proteins is low. The time to reach Cmax is 3 hours. It is almost completely excreted by the kidneys in the form of a metabolite (2-pyridylacetic acid) within 24 hours. T1 / 2 - 3-4 hours.

Indications

Treatment and prevention of vestibular dizziness of various origins.

Syndromes characterized by dizziness, headache, tinnitus, progressive hearing loss, nausea and vomiting.

Disease and Meniere's Syndrome.

Contraindications

Pregnancy.

Lactation (breastfeeding).

Hypersensitivity to the drug.

Caution: the drug should be prescribed to patients with peptic ulcer of the stomach or duodenum (including history), patients with pheochromocytoma and bronchial asthma.

Use during pregnancy and lactation

There is insufficient data to assess the effects of the drug during pregnancy and lactation, so its use during these periods is contraindicated.

Composition

1 tablet contains:

Active ingredient:

betahistine dihydrochloride - 16 mg.

Excipients:

microcrystalline cellulose,

lactose (milk sugar),

corn starch,

polyvinylpyrrolidone (povidone),

sodium carboxymethyl starch (primogel), silyl diclld

Dosage and administration of

The drug is administered orally with food.

Dose / frequency of administration:

Betaver 8 mg - 1-2 tablets 3 times a day.

Betaver 16 mg - 1 / 2-1 tablet 3 times a day.

Improvement is noted already at the beginning of therapy. A stable therapeutic effect is achieved within 2 weeks of taking the drug and can increase when taking the drug for several months.

Duration of therapy is set individually.

Side effects

Possible: violations of the gastrointestinal tract.

In very rare cases: skin manifestations of allergic reactions (skin rash, itching, urticaria), Quincke's edema.

Drug Interaction

The drug interaction of Betaver with other drugs has not been described. Cases of incompatibility are unknown.

overdose

Symptoms: nausea, vomiting when taken at a dose of more than 640 mg, convulsions may occur.

Treatment: gastric lavage, activated carbon intake, symptomatic therapy.

Storage conditions

The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.

Expiration

2 years.

Deystvuyuschee substances

betahistine

Conditions of supply of pharmacies

Prescription

Dosage Form

Dosage Form

tablets



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