Bromhexine syrup 4 mg / 5 ml with apricot flavor 100 ml (Bromhexine)

Packing

Bottle 100 ml.

Pharmacological action

Bromhexine has a mucolytic (secretolytic) and expectorant effect. The mucolytic effect is associated with the depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect. It stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during respiration. The clinical effect is manifested after 2-5 days from the start of treatment with the drug.

Pharmacokinetics

When taken orally, bromhexine is almost completely absorbed (99%) within 30 minutes. Bioavailability is 20-25% (effect of the first passage through the liver). In plasma, bromhexine firmly binds to 95% proteins, penetrates the blood-brain and placental barriers. In the liver, bromhexine undergoes demethylation and oxidation. The half-life is 15 hours due to slow back diffusion from the tissues. It is excreted by the kidneys. In chronic renal failure, the excretion of bromhexine metabolites is impaired. With repeated use, bromhexine can accumulate.

Indications

Chronic inflammatory lung disease (bronchial asthma, cystic fibrosis, tuberculosis, tracheobronchitis, spastic bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis), chest injury, pre- and postoperative period.

Contraindications

Pregnancy (I trimester), children (up to 3 years).

Use during pregnancy and lactation

During pregnancy and lactation, bromhexine is used in cases when the intended benefit to the mother outweighs the potential risk to the fetus or child.

Composition of

5 ml syrup contains:

Active ingredient: bromhexine hydrochloride - 4 mg.

Dosage and administration

Inside, 3 times a day, with water if necessary.

Adults and adolescents over 14 years of age: 8–16 mg or 2–3 teaspoons.

For children from 6 to 14 years: 4–8 mg or 1–2 teaspoons.

For children under 6 years: recommended syrup, up to 2 years - 1/2 teaspoon, from 2 to 6 years - 1/2 / 1 teaspoon.

Side effects

From the digestive system: dyspeptic symptoms, transient increase in the activity of hepatic transaminases in blood serum.

From the side of the central nervous system: headache, dizziness.

Dermatological reactions: increased sweating, skin rash.

From the respiratory system: cough, bronchospasm.

Drug Interaction

Bromhexine can be given at the same time as other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine is not prescribed at the same time as anti-cough agents (including codeine), because they can make it difficult to clear the sputum of Bromhexine.

Bromhexine promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfanilamide drugs into the bronchial secretion in the first 4-5 days of antimicrobial therapy.

Bromhexine is not compatible with alkaline solutions.

Overdose

Symptoms: nausea, vomiting, diarrhea, dyspeptic disorders.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 h after admission).

Storage conditions

Store at room temperature up to 25 ° C. Keep out of the reach of children.

term expiration date

5 years

Deystvuyuschee substances

Bromhexine

Terms of pharmacies holiday

without prescription

Pharmstandard-Leksredstva, Russia



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