Bronchobos capsules 375 mg, 30 pcs. (karbotsisteina)

Form release

Capsules

Packing

30 pcs

Pharmacological action

Bronchobos is a mucolytic (expectorant) drug.

Pharmacodynamics

Mucolytic and expectorant effect due to the activation of sialic transferase - an enzyme of goblet cells of the bronchial mucosa. Normalizes the quantitative ratio of acidic and neutral sialomucins of bronchial secretion.

Reduces the viscosity of bronchial secretions and nasal sinuses, facilitates the discharge of sputum and mucus, and reduces cough. Promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliary epithelium. Restores the secretion of IgA immunoglobulin (specific protection) and the number of sulfhydryl groups of mucus components (non-specific protection), improves mucociliary clearance.

Pharmacokinetics

Carbocysteine ​​is rapidly absorbed after oral administration. Bioavailability is low (less than 10% of the dose taken). Tmax in blood serum and in the mucous membrane of the respiratory tract is achieved 2-3 hours after ingestion and is stored in the mucous membrane for 8 hours. It is metabolized in the liver (it has the effect of "first passage" through the liver).

It is excreted mainly by the kidneys, partially in unchanged form, partially in the form of metabolites. T1 / 2 - about 2 hours.

Indications

acute and chronic bronchopulmonary diseases, accompanied by impaired formation and excretion of mucus (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis)

inflammatory diseases of the middle ear and sinuses (rhinitis, otitis media, sinusitis)

preparing the patient for bronchoscopy or bronchography.

Contraindications

hypersensitivity to the drug or its auxiliary components

peptic ulcer of the stomach and duodenum in the acute stage

chronic glomerulonephritis (in the exacerbation phase)

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Precautions: gastric ulcer and duodenal ulcer (history), chronic glomerulonephritis (history), pregnancy (II – III trimesters), breast-feeding.

Use during pregnancy and lactation

Use during pregnancy and lactation is contraindicated.

Composition

1 capsule contains:

Active ingredient:

carbocysteine ​​375.0 mg

Excipients:

corn starch - 23 mg

magnesium stearate - 2 mg

silica gelatin - 8 mg.

Dosage and Administration

Adults and adolescents over 15 years of age - 750 mg (2 capsules) 3 times a day.

After achieving the therapeutic effect, the daily dose is reduced to 1.5 g - 750 mg (2 capsules) 2 times a day.

Treatment should not last more than 8-10 days without consulting a doctor.

Side effects of

From the gastrointestinal tract: nausea, vomiting, diarrhea and epigastric pain, gastrointestinal bleeding are sometimes noted.

Hypersensitivity reaction: isolated cases of allergic reactions (skin itching, urticaria, exanthema, angioedema) have been reported.

Other: dizziness, weakness, malaise.

Overdose

Symptoms: stomach pain, nausea, diarrhea.

Treatment: symptomatic.

Storage conditions

At a temperature of 15 to 30 ° C.

Expiration

3 years.

Dispensing conditions from

pharmacies No prescription

dosage form

dosage form

capsules



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