Cardicet retard tablets 40 mg, 50 pcs. (isosorbide dinitrate)

Latin name

Cardiket

Release form

Sustained-release tablets.

Packing

50 pcs

Pharmacological action of

Peripheral vasodilator with a primary effect on venous vessels. Cardiket has an antianginal and hypotensive effect.

The mechanism of action is associated with dilatation of blood vessels (mainly post-capillary) and large arteries. Dilation of the vessels of the postcapillary bed leads to venous deposition of blood and a decrease in venous return of blood to the heart. As a result of a decrease in left ventricular filling (a decrease in preload), myocardial oxygen demand decreases, which helps to increase capillary blood flow, open the lumen of previously non-functioning intramural coronary vessels, and also improve oxygen supply to the ischemic subendocardial region.

Dilatation of precapillary vessels leads to a decrease in systolic pressure in the aorta and OPSS (decrease in afterload). As a result, the cardiac output of the left ventricle and the myocardial oxygen demand are reduced.

Direct dilatation of the coronary vessels and a slight decrease in the resistance of the coronary vessels improve myocardial perfusion and oxygen supply without the development of a robbery syndrome.

Indications

prevention of angina attacks

rehabilitation treatment after myocardial infarction

pulmonary hypertension

chronic heart failure (as part of combination therapy).

Contraindications

acute myocardial infarction

acute circulatory failure (shock, vascular collapse)

severe arterial hypotension (systolic blood pressure less than 90 mm Hg).

Use during pregnancy and lactation

The use of the drug Cardiket during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Composition

1 tablet contains:

Active ingredient: isosorbide dinitrate 40 mg

Excipients: lactose monohydrate tal b Magnesium stearate polyvinyl acetate potato starch

Dosage and administration

The dose is selected individually, because it depends on the stage of the disease and the individual need for nitrates. Tablets 40 mg - 1 tab. 2 times / day The drug should be taken after meals, without chewing and drinking with a small amount of liquid. When prescribing more than 1 tablet / day, the interval between doses should be at least 8 hours (to ensure the full effect of the drug).

Side effects

From the cardiovascular system: at the beginning of treatment - severe headache (due to dilatation of the venous channel of the brain vessels) possibly - tachycardia, orthostatic hypotension.

From the side of the central nervous system: drowsiness.

From the gastrointestinal tract: in some cases - nausea, vomiting.

Dermatological reactions: in some cases, erythematous rashes.

Drug Interaction

With the simultaneous use of Cardiket, a retard with antihypertensive drugs, cyclic antidepressants, MAO inhibitors may increase its antihypertensive effect.

When co-administered with Cardiket, retard potentiates the effect of dihydroergotamine and ethanol.

Overdose

Symptoms: headache, palpitations, dizziness, hypotension, nausea, vomiting.

Treatment: symptomatic.

Storage conditions

The drug should be stored at a temperature not exceeding 25 ° C.

Expiration

5 years.

Deystvuyuschee substances

isosorbide dinitrate

Dosage form

Dosage form

tablets prolong.



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