Ceftriaxone bottle, 1 g, 50 pcs. (Ceftriaxone)

Release form

Powder for solution for injection

Packing

50 pcs.

Pharmacological action

Ceftriaxone is a broad-spectrum, third-generation cephalosporin antibiotic. It acts bactericidal, inhibiting the synthesis of the cell membrane of microorganisms. In vitro inhibits the growth of most gram-positive and gram-negative bacteria. Resistant to b-lactamases.

Active against gram-positive aerobic bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Gram-negative aerobic bacteria Streptococcus bovis: Aeromonas spp., Alcaligenes spp., Branhamella catarrhalis (forming and non-forming beta-lactamases), Citrobacter spp., Enterobacter spp., (Some strains resistant), Escherichia coli, Haemophilus ducius Haemophilus ducius including penicillinase producing strains), Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella spp., Morganella morganii, Neisseria gonorrhoeae (including penicillinase producing strains), Neisseria meningitidis, Plesiomonas shigelloides, Proteus mirabilis, Proteus vulgaris, Salmonellapp. (including Salmonella typhi), Serratia spp. (including Serratia marsescens), Shigella spp., Vibrio spp. (including Vibrio cholerae), Yersinia spp. (including Yersinia enterocolitica), Pseudomonas aeruginosa (some strains) of anaerobic bacteria: Bacteroides spp. (including some strains of Bacteroides fragilis), Clostridium spp. (except Clostridium difficile), Fusobacterium spp. (except Fusobacterium mortiferum and Fusobacterium varium), Peptococcus spp., Peptostreptococcus spp.

Methicillin-resistant strains of Staphylococcus spp., Enterococcus spp., Bacteroides fragilis (strains producing b-lactamases) are resistant to the drug.

Indications

Bacterial infections caused by susceptible microorganisms: -

peritonitis -

sepsis -

meningitis - abdominal infections (inflammatory diseases of the gastrointestinal tract, biliary tract, including cholangitis, empyema of the gallbladder)

- upper and lower respiratory tract diseases (including pneumonia, lung abscess, pleural empyema)

- infections of bones and joints

- infections of the skin and soft tissues

- infections of the urinary tract (including pyelonephritis)

- gonorrhea

- infected wounds and burns.

Prevention of postoperative infection.

Infectious diseases in immunocompromised individuals.

Contraindications

Hypersensitivity to ceftriaxone pregnancy (I trimester).

Special instructions

Cautiously prescribe the drug to newborns (including premature) children due to the high risk of developing hyperbilirubinemia, with ulcerative colitis.

With simultaneous severe renal and hepatic insufficiency, the plasma concentration of the drug should be regularly determined.

With prolonged treatment, it is necessary to regularly monitor the picture of peripheral blood, indicators of the functional state of plasma and kidneys.

In rare cases, ultrasound of the gallbladder observes blackouts that disappear after cancellation (even if this phenomenon is accompanied by pain in the right hypochondrium, recommend continued antibiotic prescription and symptomatic treatment).

Ingredients

active substance: cefepima hydrochloride monohydrate (in terms of cefepime) - 1 g. substance) - 1.0 g.

Solvent: water d / i - 5 ml.

Dosage and Administration

Ceftriaxone is given in / m or in / in (stream or drip).

For adults and children over 12 years old, the average daily dose is 1-2 g of ceftriaxone 1 time / day.

In severe cases or in cases of infections caused by moderately sensitive pathogens, the daily dose can be increased to 4 g (2 g 2 times / day).

For newborns (up to two weeks of age), the dose is 20-50 mg / kg / day.

For infants and children up to 12 years old, the daily dose is 20-80 mg / kg.

In children weighing 50 kg or more, adult doses are used.

A dose of more than 50 mg / kg body weight should be given as an iv infusion (drip). The duration of treatment depends on the nature of the disease.

With bacterial meningitis in infants and young children, the initial dose is 100 mg / kg 1 time / day. The maximum daily dose is 4 g.

For the treatment of acute gonorrhea, the dose is 250 mg, once a / m.

To prevent infections in the preoperative and postoperative periods 30-90 minutes before surgery, 1-2 g of ceftriaxone are administered.

In case of renal failure (creatinine clearance less than 10 ml / min), the daily dose of ceftriaxone should not exceed 2 g.

In case of severe impaired liver and kidney function, as well as in patients undergoing hemodialysis, it is necessary to monitor the concentration of ceftriaxone in the blood plasma, because they may decrease the rate of its release.

Side effects

Allergic reactions: about 1% - urticaria, fever, chills, eosinophilia, rash, itching, exanthema, allergic dermatitis, exudative erythema multiforme, edema, anaphylactic shock.

From the digestive system: nausea, vomiting, stomatitis, glossitis, diarrhea, pseudomembranous enterocolitis, cholestasis, increased activity of hepatic transaminases, hyperazotemia, hypercreatininemia, increased urea.

From the side of the central nervous system: headache, dizziness.

From the hemopoietic system: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia.

Local reactions: with iv administration - phlebitis, soreness along the vein, with iv administration - soreness at the injection site.

Other: superinfection (including candidomycosis, genital mycosis) oliguria, hypocoagulation.

Drug Interactions

Ceftriaxone and aminoglycosides have synergies with many gram-negative bacteria.

Possible simultaneous administration with metronidazole, fluoroquinolones, vancomycin, rifampicin (but not in the same syringe).

When used simultaneously with loop diuretics (for example, furosemide), renal dysfunction is not observed.

Pharmaceutical Interactions

Pharmaceutically incompatible with solutions containing other antibiotics.

Overdose of

Excessively high plasma ceftriaxone concentrations cannot be reduced by hemodialysis or peritoneal dialysis. Symptomatic measures are recommended for the treatment of overdose cases.

Expiration

2 years.

active substance

Ceftriaxone

Terms of sale from

pharmacies Prescription

Dosage form

solution for injection and infusions

Prescription

Adults as prescribed by the doctor, Children as prescribed by the doctor, For pregnant women prescribed by a doctor



indications From

indications From lung inflammation, From otitis media, Bronchitis, From urinary tract infections, From intestinal infections, From skin infections, From infections of the skin, , From sinusitis, From osteomyelitis, From cholecystitis, From bile duct infections

Biochemist Saransk, Russia



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