Citramon P Renewal tablets 20 pcs. (Acetylsalicylic acid, Caffeine, Paracetamol)

Release form

Tablets are light brown in color with a flat cross section.

Indications

- mild to moderate pain syndrome (of various origins): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorrhea

- febrile syndrome: in acute respiratory diseases, including the flu.

Contraindications

- hypersensitivity to the components of the drug

- erosive and ulcerative lesions of the gastrointestinal tract (in the exacerbation phase)

- gastrointestinal bleeding (including accompanied by profuse bleeding

- deficiency of glucose-6-phosphate dehydrogenase

- glaucoma

- severe hypertension

- portal hypertension

- severe coronary heart disease

- vitamin deficiency in children with up to 15 years of age - against the background of a viral disease)

- increased irritability, sleep disturbance.

With caution

Renal failure of mild to moderate degree, liver disease, alcoholism, epilepsy and a tendency to seizures, advanced age, gout, pregnancy (II trimester).

Use during pregnancy and lactation

During pregnancy (I and III trimesters) and during breastfeeding, the drug is contraindicated.

In the second trimester of pregnancy, the drug should be used with caution, correlating the expected benefits to the mother and the potential risk to the fetus.

Special instructions

Acetylsalicylic acid slows down blood coagulation. If the patient has surgery, you should warn the doctor about taking the drug.

With prolonged use of the drug, control of peripheral blood and the functional state of the liver is necessary.

Patients with hypersensitivity or with asthma reactions to salicylic acid and its derivatives, including acetylsalicylic acid, can only be prescribed with special precautions (in emergency care).

In patients with a tendency to accumulate uric acid, taking the drug can trigger an attack of gout.

During intake, refrain from drinking alcohol (increased risk of gastrointestinal bleeding and toxic liver damage).

Acetylsalicylic acid has a teratogenic effect when used in the first trimester leads to a malformation - splitting of the upper palate in the third trimester - to inhibition of labor (inhibition of Pg synthesis), to the closure of the arterial duct in the fetus, which causes pulmonary vascular hyperplasia and hypertension in the vessels of the small blood circulation. It is excreted in breast milk, which increases the risk of bleeding in a child due to impaired platelet function.

Children under 15 years of age should not be prescribed medicines containing acetylsalicylic acid, since in the case of a viral infection they can increase the risk of Reye's syndrome. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.

Influence on driving and maintenance of vehicles requiring attention spans

There is no evidence of an impact on driving and servicing vehicles requiring attention spans.

Composition

1 tab. acetylsalicylic acid 240 mg

paracetamol 180 mg

caffeine (in terms of monohydrate) 30 mg.

Excipients:

cocoa powder - 22.5 mg,

citric acid monohydrate - 5 mg,

potato starch - 64.2 mg,

talcum - 4.9 mg,

calcium stearate - 2.8 mg,

polysorbate 80 - 0.6 mg.

Dosage and administration of

Inside (during or after a meal), 1 tab. every 4 hours, with pain, 1-2 tab. the average daily dose is 3-4 tablets. The maximum daily dose is 8 tablets. The use of the drug is not more than 7-10 days.

To reduce the irritating effect on the gastrointestinal tract, the tablet should be washed down with milk or alkaline mineral water.

Side effects of

There may be adverse reactions characteristic of acetylsalicylic acid, paracetamol and caffeine: anorexia, nausea, vomiting, gastralgia (decreased platelet aggregation), erosive and ulcerative gastrointestinal tract, gastrointestinal bronchial inflammation, erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), renal failure, liver failure, dizziness, tachycardia, increased blood pressure.

With prolonged use, dizziness, headache, visual impairment, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nosebleeds, bleeding gums, purpura, etc.), kidney damage with papillary necrosis of deafness, Reye syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, impaired liver function).

Drug Interactions

Enhances the effects of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic drugs.

Concomitant use with other non-steroidal anti-inflammatory drugs, methotrexate, increases the risk of side effects.

Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gout drugs that promote uric acid excretion.

Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other microsomal oxidation stimulants contribute to the formation of toxic paracetamol metabolites that affect liver function.

Metoclopramide accelerates the absorption of paracetamol. Under the influence of paracetamol T1 / 2 chloramphenicol increases 5 times. With repeated use, paracetamol can enhance the effect of anticoagulants (dicumarin derivatives).

Caffeine accelerates the absorption of ergotamine.

While taking the drug and alcohol-containing fluids, the risk of toxic liver damage increases.

Overdose

Do not exceed the recommended dose and duration of use!

Overdose symptoms are due to acetylsalicylic acid.

Symptoms:

- for mild intoxications: nausea, vomiting, stomach pain, dizziness, tinnitus

- for severe intoxication: lethargy, drowsiness, collapse, cramps, shortness of breath, anuria, bleeding.

Treatment: gastric lavage with activated charcoal, symptomatic therapy, depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate, which enhances the excretion of acetylsalicylic acid due to alkalization of urine.

Storage conditions of a srdlp should be stored in a dry place inaccessible to children at a temperature not exceeding 25 ° C.

Expiration

4 years.

Form of Treatment

tablets



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