Clarithromycin CP tablets coated. prolong. 500 mg 14 pcs. (clarithromycin)

Release form

Tablets.

Packing

14 pcs.

Pharmacological action

Macrolide bacteriostatic second-generation antibiotic from the macrolide group of a wide spectrum of action. It disrupts the synthesis of protein of microorganisms (binding the 50S subunit of the membrane of the ribosome of the microbial cell).

Active against: Streptococcus agalactiae (Staphylococcus pyogenes, Staphylococcus viridans, Staphylococcus pneumoniae) Haemophilus influenzae (parainfiuenzae), Haemophilus ducreyi, Neisseria gonorrhoeae, Neisseria meningitid Listeria monocytogenes, Legionella pneumophila, Mycoplasma pneumoniae, Helicobacter (Campylobacter) pylori, Campylobacter jejuni, Chlamidia pneumoniae (trachomatis), Moraxella (Branhamella) catarrhalis, Bordetella pertussis, Propionibacterium acnes, Mycobacterium avium, Mycobacterium leprae, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii , Corynebacterium spp., Borrelia burgdorferi, Pasteurella multocida, some anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus) and mycobacteria, except M. tuberculosis.

Indications

Clarithromycin is indicated for the treatment of infectious diseases caused by susceptible microorganisms. These diseases include:

Lower respiratory tract infections (bronchitis, pneumonia).

Upper respiratory tract infections (pharyngitis, sinusitis), otitis media.

Infections of the skin and soft tissues (folliculitis, erysipelas).

Common or localized mycobacterial infections, caused by Mycobacterium avium and Mycobacterium intracellular. Localized infections caused by Mycobacterium chelonae, Mycobacterium fortuitum and Mycobacterium kansasii.

Clarithromycin is indicated to eradicate H. pylori and to reduce the recurrence rate of duodenal ulcers.

Contraindications

Clarithromycin is contraindicated in patients with hypersensitivity to macrolide antibiotics.

Do not prescribe ergot derivatives for clarithromycin.

When treating with clarithromycin, it is forbidden to take cisapride, pimozide, astemizole, and terfenadine (see also the section Interaction with other drugs).

In patients taking these drugs simultaneously with clarithromycin, there is an increase in their concentration in the blood. At the same time, prolongation of the QT interval and the development of cardiac arrhythmias, including ventricular paroxysmal tachycardia, ventricular fibrillation, and ventricular flutter or fibrillation, are possible.

Severe impairment of liver and / or kidney function.

Use during pregnancy and lactation

Safety of clarithromycin during pregnancy and lactation has not been established.

Therefore, during pregnancy, clarithromycin is prescribed only in the absence of alternative therapy, if the intended benefit outweighs the possible risk to the fetus.

Clarithromycin passes into breast milk, so if you need to prescribe a drug during lactation, you should stop breast-feeding.

Dosing and Administration

For adults, the average oral dose is 250 mg 2 times / day. If necessary, 500 mg 2 times / day can be prescribed. The duration of treatment is 6-14 days.

For children, the drug is prescribed at a dose of 7.5 mg / kg body weight / day. The maximum daily dose is 500 mg. The duration of treatment is 7-10 days.

For the treatment of infections caused by Mycobacterium avium, Clarithromycin is prescribed orally - 1 g 2 times / day. The duration of treatment may be 6 months or more.

In patients with renal failure, with creatinine clearance less than 30 ml / min, the dose should be reduced by 2 times. The maximum duration of the course in patients of this group should be no more than 14 days.

Overdose

Probably the development of symptoms from the gastrointestinal tract (nausea, vomiting, diarrhea) headache, confusion.

Immediate overdose with gastric lavage and symptomatic treatment.

Hemodialysis and peritoneal dialysis do not significantly alter the serum clarithromycin level.

Storage conditions

In a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.

Expiration

2 years.

Deystvuyuschee substances

clarithromycin

terms of sale from

pharmacies Prescription

Dosage form

Dosage form

tablets prolong.

Vertex, Russia



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