Clarithromycin CP tablets coated. prolong. 500 mg 7 pcs. (clarithromycin)

Release form

Tablets.

Packaging

7 pcs

Pharmacological action

Slow-release macrolide antibiotic. The mechanism of action is the suppression of protein synthesis in a microbial cell by interaction with the ribosomal 50S subunit of bacteria. The minimum inhibitory concentration (MIC) of clarithromycin is 2 times lower than the MIC of erythromycin.

The metabolite of clarithromycin 14-hydroxyclarithromycin, has antimicrobial activity. Clarithromycin has a wide spectrum of antimicrobial activity.

drug is active against gram-positive bacteria: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, alpha hemolytic Streptococcus, Listeria monocytogenes Gram-negative organisms: Haemophilus influenzae, Haemophilus parainfluenzae, Helicobacter pylori, Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae, Legionella pneumophila, Bordetella pertussis intracellular microorganisms: Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia trachomatis, Chlamydia pneumoniae, Mycobacterium avium, Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium chelonae, Mycobacterium fort Mycobacterium intracellulare of anaerobic microorganisms: Clostridium perfringens, Peptococcus species, Peptostreptococcus species, Propionibacterium acnes, Bacteroides melaninogenicus of other microorganisms: Borrelia burgdorferi, Treponema pallidum.

Indications

Infectious and inflammatory diseases caused by susceptible microorganisms:

- respiratory tract infections (sinusitis, pharyngitis, bronchitis, pneumonia)

- infections of the skin and soft tissues (folliculitis, erysipelas)

- Helicobacter pylori-associated diseases of the stomach and duodenum.

Contraindications

- porphyria

- renal failure (CC less than 30 ml / min)

- concomitant use of cisapride, pimoside and terfenadine, astemizole, ergotamine and other ergot alkaloids, fructose malignancy, or srdlactose

- I trimester of pregnancy

- lactation (breastfeeding)

- children under 18 years old

- hypersensitivity to the components of the drug

- hypersensitivity to antibiotics from g groups of macrolides.

Use during pregnancy and lactation

Use in the first trimester of pregnancy and during lactation (breastfeeding) is contraindicated.

Composition

1 tablet contains:

Active ingredient:

clarithromycin 500 mg.

Excipients:

hypromellose 2208 (100 mPa • s) 200 mg,

hypromellose (hydroxypropyl methylcellulose) 2910 (50 mPa • s) 150 mg,

microcrystalline cellulose 137.5 mg,

silicon dioxide 10 mg mg colloidal magnesium.

The composition of the film membrane:

hypromellose 2910 (6 MPa • s) 15 mg,

hyprolose 5.82 mg,

talc 5.778 mg,

titanium dioxide 3.261 mg,

iron oxide yellow 0.141 mg

Dosage and administration of

Clarithromycin SR is prescribed for adults and children over 18 years old at a dose of 500 mg (1 tablet) with meals. If necessary, it is possible to increase the dose to 1 g (2 tablets) per dose or in 2 doses with an interval of 12 hours. The average daily dose is 500 mg. The maximum daily dose is 1 g.

The duration of treatment, as a rule, is 7-14 days.

Side effects

Often: headache, dizziness, anxiety, fear of nausea, vomiting, abdominal pain, diarrhea.

Sometimes: candidal stomatitis, glossitis, discoloration of the tongue and teeth arthralgia, myalgia, skin rash, urticaria paresthesia, taste perversion, visual disturbances, increased activity of hepatic transaminases, plasma creatinine.

Rarely: insomnia, tinnitus, uveitis disorientation, hallucinations, psychosis, depersonalization, confusion tachycardia, ventricular arrhythmia, pseudomembranous enterocolitis, hepatitis, cholestatic jaundice, pancreatitis, interstitial nephritis, renal failure, hypoglycemia thrombocytopenia Stevens-Johnson syndrome (malignant exudative erythema) and toxic epidermal necrolysis.

In isolated cases: hearing loss that occurs after discontinuation of the drug.

Overdose

Symptoms: nausea, vomiting, abdominal pain, diarrhea, headache, confusion.

Treatment: gastric lavage, symptomatic therapy.

Storage conditions

The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25 ° C.

Expiration

2 Year

Deystvuyuschee substance

Clarithromycin

Pharmacy

Pharmacy Prescription

Dosage form

Dosage form

tablets prolong.

Vertex, Russia



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