Clarithromycin-OBL tablets coated. 500 mg 14 pcs. (clarithromycin)
Special Price
$27.20
Regular Price
$32.00
In stock
SKU
newyork468148
Release form
Film-coated tablets Buy Clarithromycin-OBL tablets coated. 500 mg 14 pcs. (clarithromycin) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Film-coated tablets Buy Clarithromycin-OBL tablets coated. 500 mg 14 pcs. (clarithromycin) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Film-coated tablets
Packing
14 pcs.
Pharmacological action
Pharmacotherapeutic group:
antibiotic, macrolide.
Pharmacodynamics:
Clarithromycin is a second-generation bacteriostatic antibiotic from the broad-spectrum macrolide group. It disrupts the synthesis of protein of microorganisms (binds to the 50S subunit of the membrane of the ribosome of the microbial cell). It acts on extra- and intracellularly located pathogens. It is active against:
Streptococcus agalactiae (Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae), Haemophilus influenzae (parainfluenzae), Haemophilus ducreyi, Neisseria gonorrhoeaeliofiliofemofilema phélioplegis campiofilemaphilofemaphilemaphilofemaphilemaphilofema, lei phylophilioephilofilioemofilofema Campina , Chlamidia pneumoniae, Moraxella catarrhalis, Bordetella pertussis, Propionibacterium acne, Mycobacterium avium, Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium marinom, Staphylococumulus urelorem urelioperloma bleury some anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus), less active against Mycobacterium tuberculosis.
Pharmacokinetics:
Absorption - fast. Food slows down absorption, without significantly affecting bioavailability. Communication with plasma proteins - more than 90%. After a single dose, 2 peaks of the maximum concentration of the drug in the blood plasma are recorded.
The second peak is due to the ability of the drug to concentrate in the gallbladder, followed by gradual or rapid entry into the intestines and absorption. The time to reach the maximum concentration of the drug in blood plasma with oral administration of 250 mg is 1-3 hours.
After oral administration, 20% of the dose taken is rapidly hydroxylated in the liver by CYP3A4 cytochrome enzymes. CYP3A5 and CYP3A7 with the formation of the main metabolite, β-14-hydroxyclarithromycin, with pronounced antimicrobial activity against Haemophilus influenzae. It is an inhibitor of isoenzymes CYP3A4, CYP3A5 and CYP3A7.
With regular intake of 250 mg / day, the equilibrium concentrations of the unchanged drug and its main metabolite are 1 and 0.6 μg / ml, respectively, the half-life is 3-4 hours and 5-6 hours, respectively.
With an increase in dose to 500 mg / day, the equilibrium concentration of unchanged drug and its metabolite in plasma is 2.7-2.9 and 0.83-0.88 μg / ml, respectively, the half-life is 4.8-5 hours and 6 9-8.7 hours, respectively. At therapeutic concentrations, it accumulates in the lungs, skin and soft tissues (in them, concentrations are 10 times higher than the level in blood serum).
It is excreted by the kidneys and intestines (20-30% - in unchanged form, the rest - in the form of metabolites). With a single dose of 250 mg and 1200 mg, 37.9 and 46% are excreted by the kidneys, 40.2 and 29.1%, respectively, by the intestines.
Indications
- Lower respiratory tract infections (including bronchitis, pneumonia).
- Infections of the upper respiratory tract (including pharyngitis, sinusitis).
- Infections of the skin and soft tissues (including folliculitis, erysipelas).
- Mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare. Localized infections caused by Mycobacterium fortuitum and Mycobacterium kansasii.
- Prevention of the spread of infection caused by the Mycobacterium avium complex (MAC infection) in HIV-infected patients with a CD4 count of not more than 100 / μl.
- Eradication of Helicobacter pylori to reduce the recurrence rate of gastric ulcer and duodenal ulcer.
- Odontogenic infections.
Contraindications
В· hypersensitivity to the drugs of the
macrolide group В· simultaneous administration of clarithromycin with the following drugs: astemizole, cisapride, pimozide and terfenadine
В· porphyria
В· pregnancy (I trimester).
Precautions: Renal and / or liver failure. Against the background of taking drugs metabolized by the liver, it is recommended to measure their concentration in the blood.
Use during pregnancy and lactation
Use of the drug during pregnancy (II and III trimesters) is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
Clarithromycin is excreted in breast milk, so if you need to prescribe the drug during lactation, you should stop breastfeeding.
Special instructions
In the presence of chronic liver diseases, regular monitoring of serum enzymes is necessary.
With caution is prescribed against the background of drugs metabolized by the liver (it is recommended to measure their concentration in the blood).
In the case of co-administration with warfarin or other indirect anticoagulants, prothrombin time must be monitored.
It is necessary to pay attention to the possibility of cross-resistance between clarithromycin and other macrolide antibiotics, as well as lincomycin and clindamycin.
With prolonged or repeated use of the drug, superinfection is possible (the growth of insensitive bacteria and fungi).
Composition
One tablet contains:
active substance - clarithromycin - 250 mg or 500 mg.
Excipients:
croscarmellose sodium,
sodium lauryl sulfate,
microcrystalline cellulose,
povidone (polyvinylpyrrolidone, low molecular weight Medical),
magnesium stearate,
colloidal silicon dioxide (Aerosil),
hypromellose (hydroxypropylmethylcellulose),
macrogol (polyethylene glycol 6000),
titanium dioxide,
hyprolose (hydroxypropylcellulose),
dye quinoline yellow,
vanillin.
Dosage and administration
Inside, adults and children over 12 years old - 250-500 mg 2 times a day. The duration of treatment is 6-14 days.
In the treatment of infections caused by Mycobacterium avium, 500 mg is prescribed orally 2 times a day. The duration of treatment is 6 months or more.
To eradicate Helicobacter pylori in patients with peptic ulcer and duodenal ulcer, clarithromycin is prescribed 250-500 mg twice a day as part of combination therapy. The duration of treatment is 7-14 days.
In patients with chronic renal failure (creatinine clearance less than 30 ml / min or serum creatinine concentrations more than 3.3 mg / 100 ml) - 250 mg / day (once), in severe infections - 250 mg 2 times a day. The maximum duration of treatment in patients of this group is 14 days.
Side effects
From the nervous system: headache, dizziness, anxiety, fear, insomnia, nightmares, rarely - disorientation, hallucinations, psychosis, depersonalization, confusion.
From the digestive system: nausea, vomiting, gastralgia, diarrhea, stomatitis, glossitis, increased activity of hepatic transaminases, cholestatic jaundice, rarely - pseudomembranous enterocolitis.
From the sensory organs: tinnitus, taste change (dysgeusia) in isolated cases - hearing loss that occurs after drug withdrawal.
From the hemopoietic organs and hemostatic system: rarely - thrombocytopenia (unusual bleeding, hemorrhage).
Allergic reactions: skin rash, itching, malignant exudative erythema (Stevens-Johnson syndrome), anaphylactoid reactions.
Others: development of microbial resistance.
Drug interaction
The simultaneous use of clarithromycin with cisapride, pimozide, terfenadine, astemizole is contraindicated, since this leads to an increase in the concentration of these drugs in blood plasma by a factor of 2–3, which can cause a prolongation of the QT interval, disturbance of the heart rhythm, including ventricular tachycardia, and ventricular fibrillation.
With concomitant use, clarithromycin increases the concentration in the blood of drugs metabolized in the liver by cytochrome P450 enzymes: indirect anticoagulants, carbamazepine, theophylline, triazolam, midazolam, cyclosporine, vinblastine, disopyramide, phenytoin, simvafastifa, dolifastifa, rifolafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-olafa valproic acid, cilostazol, methylprednisolone, omeprazole, quinidine, ergot alkaloids, sildenafil, tacrolimus.
With the simultaneous administration of clarithromycin and zidovudine in HIV-infected patients, a decrease in the equilibrium concentration of zidovudine was noted (an interval of at least 4 hours is required between the use of drugs).
With the simultaneous use of ritonavir (200 mg every 8 hours) and clarithromycin (500 mg every 12 hours), the metabolism of clarithromycin slows down (Cmax of clarithromycin increased by 31%, Cmin - by 182%, AUC - by 77%). A significant slowdown in the formation of 14-hydroxyclarithromycin was noted.
When taking ritonavir, clarithromycin should not be prescribed at a dose of more than 1 g per day. In this case, in patients without impaired renal function, there is no need for dose adjustment of clarithromycin. This is of great importance in the case of the use of such a combination in patients with impaired renal function: in patients with creatinine clearance from 30 to 60 ml / min, the dose of clarithromycin is reduced by 50% (up to 500 mg once a day).
Possible development of cross-resistance between clarithromycin, lincomycin and clindamycin.
Overdose
Symptoms: nausea, vomiting, diarrhea, headache, confusion.
Treatment: gastric lavage and symptomatic treatment.
Hemodialysis and peritoneal dialysis do not lead to a significant change in the concentration of clarithromycin in the serum.
Storage Conditions
List B. Store in a dry, dark place at a temperature not exceeding 20 ° C.
Keep out of the reach and sight of children!
Shelf life
2 years. Do not use after the expiration date indicated on the package.
Deystvuyushtee substance
Clarithromycin
Terms and conditions
prescription
dosage form
tablets
Prescription
Prescription
Adults as prescribed by the doctor, Children as prescribed doctor
Obolenskoye FP, Russia
Clarithromycin-OBL tablets coated. 500 mg 14 pcs. (clarithromycin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Clarithromycin-OBL tablets coated. 500 mg 14 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Film-coated tablets
Packing
14 pcs.
Pharmacological action
Pharmacotherapeutic group:
antibiotic, macrolide.
Pharmacodynamics:
Clarithromycin is a second-generation bacteriostatic antibiotic from the broad-spectrum macrolide group. It disrupts the synthesis of protein of microorganisms (binds to the 50S subunit of the membrane of the ribosome of the microbial cell). It acts on extra- and intracellularly located pathogens. It is active against:
Streptococcus agalactiae (Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae), Haemophilus influenzae (parainfluenzae), Haemophilus ducreyi, Neisseria gonorrhoeaeliofiliofemofilema phélioplegis campiofilemaphilofemaphilemaphilofemaphilemaphilofema, lei phylophilioephilofilioemofilofema Campina , Chlamidia pneumoniae, Moraxella catarrhalis, Bordetella pertussis, Propionibacterium acne, Mycobacterium avium, Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium marinom, Staphylococumulus urelorem urelioperloma bleury some anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus), less active against Mycobacterium tuberculosis.
Pharmacokinetics:
Absorption - fast. Food slows down absorption, without significantly affecting bioavailability. Communication with plasma proteins - more than 90%. After a single dose, 2 peaks of the maximum concentration of the drug in the blood plasma are recorded.
The second peak is due to the ability of the drug to concentrate in the gallbladder, followed by gradual or rapid entry into the intestines and absorption. The time to reach the maximum concentration of the drug in blood plasma with oral administration of 250 mg is 1-3 hours.
After oral administration, 20% of the dose taken is rapidly hydroxylated in the liver by CYP3A4 cytochrome enzymes. CYP3A5 and CYP3A7 with the formation of the main metabolite, β-14-hydroxyclarithromycin, with pronounced antimicrobial activity against Haemophilus influenzae. It is an inhibitor of isoenzymes CYP3A4, CYP3A5 and CYP3A7.
With regular intake of 250 mg / day, the equilibrium concentrations of the unchanged drug and its main metabolite are 1 and 0.6 μg / ml, respectively, the half-life is 3-4 hours and 5-6 hours, respectively.
With an increase in dose to 500 mg / day, the equilibrium concentration of unchanged drug and its metabolite in plasma is 2.7-2.9 and 0.83-0.88 μg / ml, respectively, the half-life is 4.8-5 hours and 6 9-8.7 hours, respectively. At therapeutic concentrations, it accumulates in the lungs, skin and soft tissues (in them, concentrations are 10 times higher than the level in blood serum).
It is excreted by the kidneys and intestines (20-30% - in unchanged form, the rest - in the form of metabolites). With a single dose of 250 mg and 1200 mg, 37.9 and 46% are excreted by the kidneys, 40.2 and 29.1%, respectively, by the intestines.
Indications
- Lower respiratory tract infections (including bronchitis, pneumonia).
- Infections of the upper respiratory tract (including pharyngitis, sinusitis).
- Infections of the skin and soft tissues (including folliculitis, erysipelas).
- Mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare. Localized infections caused by Mycobacterium fortuitum and Mycobacterium kansasii.
- Prevention of the spread of infection caused by the Mycobacterium avium complex (MAC infection) in HIV-infected patients with a CD4 count of not more than 100 / μl.
- Eradication of Helicobacter pylori to reduce the recurrence rate of gastric ulcer and duodenal ulcer.
- Odontogenic infections.
Contraindications
В· hypersensitivity to the drugs of the
macrolide group В· simultaneous administration of clarithromycin with the following drugs: astemizole, cisapride, pimozide and terfenadine
В· porphyria
В· pregnancy (I trimester).
Precautions: Renal and / or liver failure. Against the background of taking drugs metabolized by the liver, it is recommended to measure their concentration in the blood.
Use during pregnancy and lactation
Use of the drug during pregnancy (II and III trimesters) is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
Clarithromycin is excreted in breast milk, so if you need to prescribe the drug during lactation, you should stop breastfeeding.
Special instructions
In the presence of chronic liver diseases, regular monitoring of serum enzymes is necessary.
With caution is prescribed against the background of drugs metabolized by the liver (it is recommended to measure their concentration in the blood).
In the case of co-administration with warfarin or other indirect anticoagulants, prothrombin time must be monitored.
It is necessary to pay attention to the possibility of cross-resistance between clarithromycin and other macrolide antibiotics, as well as lincomycin and clindamycin.
With prolonged or repeated use of the drug, superinfection is possible (the growth of insensitive bacteria and fungi).
Composition
One tablet contains:
active substance - clarithromycin - 250 mg or 500 mg.
Excipients:
croscarmellose sodium,
sodium lauryl sulfate,
microcrystalline cellulose,
povidone (polyvinylpyrrolidone, low molecular weight Medical),
magnesium stearate,
colloidal silicon dioxide (Aerosil),
hypromellose (hydroxypropylmethylcellulose),
macrogol (polyethylene glycol 6000),
titanium dioxide,
hyprolose (hydroxypropylcellulose),
dye quinoline yellow,
vanillin.
Dosage and administration
Inside, adults and children over 12 years old - 250-500 mg 2 times a day. The duration of treatment is 6-14 days.
In the treatment of infections caused by Mycobacterium avium, 500 mg is prescribed orally 2 times a day. The duration of treatment is 6 months or more.
To eradicate Helicobacter pylori in patients with peptic ulcer and duodenal ulcer, clarithromycin is prescribed 250-500 mg twice a day as part of combination therapy. The duration of treatment is 7-14 days.
In patients with chronic renal failure (creatinine clearance less than 30 ml / min or serum creatinine concentrations more than 3.3 mg / 100 ml) - 250 mg / day (once), in severe infections - 250 mg 2 times a day. The maximum duration of treatment in patients of this group is 14 days.
Side effects
From the nervous system: headache, dizziness, anxiety, fear, insomnia, nightmares, rarely - disorientation, hallucinations, psychosis, depersonalization, confusion.
From the digestive system: nausea, vomiting, gastralgia, diarrhea, stomatitis, glossitis, increased activity of hepatic transaminases, cholestatic jaundice, rarely - pseudomembranous enterocolitis.
From the sensory organs: tinnitus, taste change (dysgeusia) in isolated cases - hearing loss that occurs after drug withdrawal.
From the hemopoietic organs and hemostatic system: rarely - thrombocytopenia (unusual bleeding, hemorrhage).
Allergic reactions: skin rash, itching, malignant exudative erythema (Stevens-Johnson syndrome), anaphylactoid reactions.
Others: development of microbial resistance.
Drug interaction
The simultaneous use of clarithromycin with cisapride, pimozide, terfenadine, astemizole is contraindicated, since this leads to an increase in the concentration of these drugs in blood plasma by a factor of 2–3, which can cause a prolongation of the QT interval, disturbance of the heart rhythm, including ventricular tachycardia, and ventricular fibrillation.
With concomitant use, clarithromycin increases the concentration in the blood of drugs metabolized in the liver by cytochrome P450 enzymes: indirect anticoagulants, carbamazepine, theophylline, triazolam, midazolam, cyclosporine, vinblastine, disopyramide, phenytoin, simvafastifa, dolifastifa, rifolafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-azafa, rifa-olafa valproic acid, cilostazol, methylprednisolone, omeprazole, quinidine, ergot alkaloids, sildenafil, tacrolimus.
With the simultaneous administration of clarithromycin and zidovudine in HIV-infected patients, a decrease in the equilibrium concentration of zidovudine was noted (an interval of at least 4 hours is required between the use of drugs).
With the simultaneous use of ritonavir (200 mg every 8 hours) and clarithromycin (500 mg every 12 hours), the metabolism of clarithromycin slows down (Cmax of clarithromycin increased by 31%, Cmin - by 182%, AUC - by 77%). A significant slowdown in the formation of 14-hydroxyclarithromycin was noted.
When taking ritonavir, clarithromycin should not be prescribed at a dose of more than 1 g per day. In this case, in patients without impaired renal function, there is no need for dose adjustment of clarithromycin. This is of great importance in the case of the use of such a combination in patients with impaired renal function: in patients with creatinine clearance from 30 to 60 ml / min, the dose of clarithromycin is reduced by 50% (up to 500 mg once a day).
Possible development of cross-resistance between clarithromycin, lincomycin and clindamycin.
Overdose
Symptoms: nausea, vomiting, diarrhea, headache, confusion.
Treatment: gastric lavage and symptomatic treatment.
Hemodialysis and peritoneal dialysis do not lead to a significant change in the concentration of clarithromycin in the serum.
Storage Conditions
List B. Store in a dry, dark place at a temperature not exceeding 20 ° C.
Keep out of the reach and sight of children!
Shelf life
2 years. Do not use after the expiration date indicated on the package.
Deystvuyushtee substance
Clarithromycin
Terms and conditions
prescription
dosage form
tablets
Prescription
Prescription
Adults as prescribed by the doctor, Children as prescribed doctor
Obolenskoye FP, Russia
Clarithromycin-OBL tablets coated. 500 mg 14 pcs. (clarithromycin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Clarithromycin-OBL tablets coated. 500 mg 14 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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