Clarithromycin-Teva tablets coated. 500 mg 14 pcs. (clarithromycin)

Release form

Coated tablets

Packing

14 pcs.

Pharmacological action of

Clarithromycin-Teva - an antibiotic of the macrolide group - inhibits protein synthesis in a microbial cell by interacting with the 50S ribosomal subunit of bacteria. It is active against Streptococcus agalactiae (pyogenes, viridans, pneumoniae), Haemophilus influenzae (parainfluenzae), Neisseria gonorrhoeae, Listeria monocytogenes, Legionella pneumophilia, Mycoplasma pneumoniae, Helicobacterlomella chlamydermaera campelomella chlamdis pomori, Campilobrichrechljebrjebrjebrje dellum pertussis, Propionibacterium acnes, Mycobacterium avium, Mycobacterium leprae, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii. When administered, clarithromycin is metabolized with the formation of the main metabolite, 14-hydroxyclarithromycin, which has the same or 1-2 orders of magnitude lower (depending on the type of microorganism) antimicrobial activity than the unchanged substance.

Indications

Infections caused by microorganisms sensitive to clarithromycin - upper respiratory tract infections (laryngitis, pharyngitis, tonsillitis and sinusitis) infections of the lower respiratory tract (bronchitis, bacterial pneumonia) infections of the skin and soft tissues (folliculitis, furunculosis, impetigo, wound infection) infections caused by Mycobacterium avium, Chlamydia trachomatis, Helicobacter pylori, Ureticlasma.

Contraindications

hypersensitivity to the drugs of the

macrolide group, concomitant use of clarithromycin with the following drugs: astemizole, cisapride, pimozide and terfenadine

porphyria

pregnancy (I trimester)

lactation period

children under 12 years old.

Use during pregnancy and lactation

Use of Clarithromycin-Teva during pregnancy (II and III trimesters) is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. Clarithromycin is excreted in breast milk, so if you need to prescribe the drug during lactation, you should stop breastfeeding.

Special instructions

Use with caution in patients with impaired liver and / or kidney function. In the first trimester of pregnancy, prescribed only by absolute indications.

Composition

1 film-coated tablet contains:

The active substance is clarithromycin 500, 0 mg

Excipients - povidone, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate

Shell composition: Opadry II 31F58914 white (patented mixture containing hypromellose, lactose monohydrate, titanium dioxide macrogitol (E171). .

Dosage and administration of

Clarithromycin-Teva is taken orally, adults and children over 12 years old - 250-500 mg 2 times a day. The duration of treatment is 6-14 days. In the treatment of infections caused by Mycobacterium avium, 500 mg is prescribed orally 2 times a day. The duration of treatment is 6 months or more. To eradicate Helicobacter pylori in patients with peptic ulcer and duodenal ulcer, clarithromycin is prescribed 250-500 mg twice a day as part of combination therapy. The duration of treatment is 7-14 days. In patients with chronic renal failure (creatinine clearance less than 30 ml / min or serum creatinine concentrations more than 3.3 mg / 100 ml) - 250 mg / day (once), in severe infections - 250 mg 2 times a day. The maximum duration of treatment in patients of this group is 14 days.

Side effects

Possible nausea, vomiting, epigastric pain, diarrhea, transient increase in liver transaminase activity, skin rash, headache.

Drug interaction

With the simultaneous administration of clarithromycin with theophylline and carbamazepine, an increase in the content of the latter in the blood plasma was noted.

Overdose

Symptoms: nausea, vomiting, diarrhea.

Treatment: wash your stomach as fast as possible, prescribe symptomatic therapy.

Storage conditions

Store in a dry, dark place out of reach of children at temperatures up to 25 ° C.

Active substance

Clarithromycin

prescription

Prescription

lekarstvennaja form

tablets

Prescription

Adults as prescribed by a doctor, Children over 12 years old, Children as prescribed by a doctor, For pregnant women prescribed by a doctor

Teva Pharmaceutical Enterprise Co., Ltd., Israel



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