Clotrimazole ointment 1%, 15 g (Clotrimazolum)

Latin name

Travocort p8roklut5 dp Ind

Release form

Ointment for external use

Pharmacological action

Clotrimazole - trichomonacid, antiprotozoal, antifungal, antibacterial.

Destroys the cytoplasmic membrane of microorganisms with the formation of vacuoles inside the cell, inhibits the synthesis of nucleic acids and proteins.

Pharmacodynamics

It has a wide range of fungicidal effects: effective against yeast (Candida albicans) and mold (phycomycetes) fungi, dermatophytes (including Trichophyton, Epidermophyton, Microsporum), Malassezia furfur includes an antibacterial spectrum. h Corynebacterium minutissima.

Pharmacokinetics

Poorly absorbed from the skin and mucous membranes. Accumulates in the stratum corneum of the epidermis.

Indications

Dermatomycosis, multicolor lichen, erythrasma, candida vulvovaginitis or balanitis.

Contraindications

Hypersensitivity to clotrimazole or excipients, I trimester of pregnancy.

Caution - lactation.

Use during pregnancy and lactation

In clinical and experimental studies, it was not found that the use of the drug during pregnancy or during lactation has a negative effect on the health of a woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor. Applying the drug directly to the lactating mammary gland is contraindicated.

Composition

100 g ointments for external use contain:

Active ingredient: clotrimazole 1 g

Excipients: propylene glycol, polyethylene oxide 1500, polyethylene oxide 400, nipagin (methyl parahydroxybenzoate) or methyl paraben.

Dosage and Administration

Externally. The ointment is applied in a thin layer 2-3 times a day on previously cleaned (using soap with a neutral pH value) and dry affected areas of the skin and gently rubbed. The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy. Treatment of dermatomycosis is carried out for at least 4 weeks, pityriasis versicolor -1-3 weeks. In case of fungal diseases of the skin of the legs, it is recommended that therapy be continued for at least 2 weeks after the elimination of the symptoms of the disease.

Side effects

Lower gastrointestinal spasms, generalized erythema, rash, local allergic reactions (burning, itching).

Drug Interaction

Amphotericin B, Nystatin, natamycin reduces the effectiveness of clotrimazole when used concomitantly. When applying ointments, negative interactions with other agents are not known and should not be expected because Clotrimazole resorption capacity is very low.

overdose

Ointment at high doses does not cause any life-threatening reactions and conditions.

Storage conditions

In a dry, dark place at a temperature of 15–25 ° C.

Expiration

3 years.

Deystvuyuschee substances

Clotrimazolum

dosage form

dosage form

ointment

Murom Instrument Making Plant, Russia



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