Coldrex HotRem with honey and lemon flavor sachets 5 g, 10 pcs. (Paracetamol, phenylephrine, ascorbic acid)

Briefly about the product

Coldrex HotRem - combined drug, the effect of which is due to the active components that are part of:

Paracetamol has analgesic and antipyretic effects.

Phenylephrine is a vasoconstrictor, relieves nasal congestion (narrows the vessels of the nasal mucosa and paranasal sinuses) and facilitates breathing.

Ascorbic acid (Vitamin C) fulfills the need for Vitamin C in case of rest and flu.

The active substances of Coldrex HotRem do not cause drowsiness. *

* Instructions for medical use, RU Рџ N016305 / 01

Description

Powder for oral solution (honey-lemon) heterogeneous, from grayish-white with a beige tint to light brown with white, light brown and dark brown inclusions the prepared solution is from light yellow to light brown in color with insoluble inclusions of white color and a characteristic smell of lemon and honey.

Latin name

Coldrex Hotrem

Packaging

5 g - sachets (10) - packs of cardboard.

Pharmacological action

Combined agent whose action is due to its constituent components.

Paracetamol is an analgesic and antipyretic. The mechanism of its action is supposedly to suppress the synthesis of prostaglandins, mainly in the central nervous system.

Paracetamol has an extremely small effect on the synthesis of prostaglandins in peripheral tissues, it does not alter the water-electrolyte metabolism and does not damage the mucous membrane of the gastrointestinal tract.

This property of paracetamol makes the drug particularly suitable for patients with a history of gastrointestinal diseases (for example, patients with a history of gastrointestinal bleeding or elderly patients) or patients taking concomitant medication in which suppression of the synthesis of peripheral prostaglandins may be undesirable .

Phenylephrine hydrochloride is a sympathomimetic drug whose action is aimed at stimulating adrenoreceptors (mainly -adrenoreceptors), which leads to a decrease in swelling of the nasal mucosa and facilitation of nasal breathing.

Ascorbic acid (vitamin C) makes up for the increased need for vitamin C for “colds” and flu, especially in the initial stages of the disease.

The components of the preparation do not cause drowsiness or disturb attention span.

Indications

To eliminate symptoms of acute respiratory infections and flu, including: - elevated body temperature

- headache

- chills

- pain in the joints and muscles

- nasal congestion

- sore throat and sinuses.

Contraindications

- Severe hepatic impairment

- severe renal impairment

- hyperthyroidism (including thyrotoxicosis)

- diabetes mellitus

- sucrose / isomaltase deficiency, maltose fructose intolerance, the preparation contains sucrose

- heart disease (severe stenosis of the aortic orifice, acute myocardial infarction, tachyarrhythmias)

- arterial hypertension

- simultaneous administration of tricyclic antidepressants, beta-blockers, MAO inhibitors and up to 14 days after their withdrawal

- simultaneous use of other paracetamol-containing drugs and funds to relieve cold and cold symptoms - benign prostatic hyperplasia

- angle-closure glaucoma

- children under 12 years old

- hypersensitivity to the components of the drug

Recommendations for using

If you have any of the following diseases / conditions / risk factors, be sure to consult your doctor before taking the drug:

Benign hyperbilirubinemia.

Impaired liver and kidney function of mild to moderate severity.

Alcoholic liver disease.

Cardiovascular disease, including high blood pressure, obliterating vascular disease (Raynaud's syndrome).

Pheochromocytoma.

The presence of severe infections, including sepsis, because taking the drug may increase the risk of metabolic acidosis.

Patients with glutathione deficiency (in particular, extremely malnourished patients suffering from anorexia, chronic alcoholism or patients with a low body mass index).

Concomitant use of antihypertensive drugs.

Pregnancy and the period of breastfeeding.

Indications for treatment of the disease

Pregnancy

The drug should not be used during pregnancy without first consulting a doctor!

In studies in animals and humans, there was no risk of paracetamol during pregnancy or a negative effect on fetal development.

There are no sufficient data on the effect of drugs containing phenylephrine on pregnancy.

Breastfeeding period

The drug should not be used during breastfeeding without first consulting a doctor!

Paracetamol crosses the placental barrier and into breast milk. In studies conducted in humans, no adverse effects on the baby’s body were found during breastfeeding.

Phenylephrine may pass into breast milk.

Special instructions

Patient should be informed that that if the symptoms of the disease persist after 5 days of using the drug, you should stop taking it and consult a doctor.

The drug should be taken only at recommended doses.

The patient should stop taking the drug and consult a doctor immediately if the following side effects occur:

allergic reactions: itching or redness of the skin, difficulty breathing or swelling of the lips, tongue, throat or face

rash or peeling on the skin, ulceration of the mucous membrane

mouth bruising or bleeding

vision loss. This may be due to increased intraocular pressure. Very rarely, but with the greatest probability this side effect is observed in patients with glaucoma

, a feeling of a strong heartbeat or an increase in heart rate or heart rhythm disturbances

difficulty urinating. More often this side effect is observed in patients with prostatic hypertrophy.

You should not take the drug if respiratory problems have been observed while taking acetylsalicylic acid or other NSAIDs.

The drug should not be taken simultaneously with other drugs containing paracetamol, as well as other non-narcotic analgesics (metamizole sodium), NSAIDs (acetylsalicylic acid, ibuprofen), barbiturates, anticonvulsants, rifampicin and chloramphenicol, sympathomimetics, such as decatomimetics, such as decatomimetics, appetite, amphetamine-like psychostimulants), with other agents to relieve symptoms of the common cold and flu.

When conducting tests to determine uric acid and the level of glucose in the blood, the patient must inform the doctor about the use of Coldrex® HotRem, as the drug may distort the results of laboratory tests evaluating the concentration of glucose and uric acid.

Before taking Coldrex® HotRem (lemon), you need to consult a doctor if: taking metoclopramide, domperidone (used to eliminate nausea and vomiting) or colestyramine used to lower blood cholesterol

taking drugs to reduce blood coagulation (for example, warfarin)

low sodium diet - each sachet contains 0. 12 g of sodium

of a serious infectious disease (including sepsis) in patients with glutathione deficiency, because while taking paracetamol, the risk of metabolic acidosis may increase, signs of which are a violation of the frequency and depth of breathing, accompanied by a feeling of lack of air (shortness of breath), nausea, vomiting, loss of appetite. If the patient discovers these, consult a doctor immediately.

Patients with phenylketonuria are not recommended to take Coldrex® HotRem (lemon-honey), as it contains aspartame, which is a source of phenylalanine. Before taking Coldrex® HotRem (lemon-honey), you need to consult a doctor in the following cases: taking warfarin or other indirect anticoagulants

taking medications to control blood pressure, for example beta-blockers

taking digoxin or other cardiac glycosides to treat heart failure

taking drugs to reduce appetite or psychostimulants

taking drugs to treat depression (tricyclic antidepressants - amitriptyline)

taking metoclopramide, domperidone or used by

to lower

blood cholesterol if a hyponatrium diet is required (each packet contains 0.12 g of sodium).

In order to avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, and should also be taken by people who drink alcohol chronically.

Effect on the ability to drive vehicles and mechanisms

When taken in recommended doses, the drug does not affect the ability to drive vehicles and mechanisms, as well as engage in other potentially dangerous activities that require concentration and speed of psychomotor reactions. When dizziness occurs, it is not recommended to drive vehicles or work with mechanisms.

Composition

Phenylephrine

Paracetamol

Ascorbic acid

Dosage and administration

For oral administration.

Do not exceed the specified dose!

The lowest dose needed to achieve the effect should be used!

The minimum interval between doses of Coldrex® HotRem should be at least 4 hours.

Contain 1 sachet in a mug, pour hot water, stir until dissolved.

Add cold water and sugar if necessary.

Adults (including the elderly) and children over 12 years: Inside, single dose - 1 sachet. Repeated use of the drug is possible no earlier than 4-6 h and no more than 4 times / day. The maximum daily dose should not exceed 4 sachets. The maximum duration of the drug without consulting a doctor should be no more than 5 days.

Do not take at the same time as other paracetamol-containing agents, decongestants and agents to relieve the symptoms of colds and flu, as well as with ethanol-containing drugs and drinks.

If the symptoms of the disease persist when taking the drug, you should consult a doctor.

Drug interactions

Paracetamol when taken for a long time enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Occasional administration of a single dose of the drug does not significantly affect the effect of indirect anticoagulants.

Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effects in case of overdose and concomitant use.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Paracetamol reduces the effectiveness of diuretic drugs.

Metoclopramide and domperidone increase, and colestyramine decreases the rate of absorption of paracetamol.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

Phenylephrine when taken with MAO inhibitors may increase blood pressure.

Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs, increases the risk of developing hypertension and disorders of the cardiovascular system.

The simultaneous use of phenylephrine with sympathomimetic amines may increase the risk of side effects from the cardiovascular system.

Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, may increase the risk of side effects from the cardiovascular system.

The simultaneous use of halothane with phenylephrine increases the risk of ventricular arrhythmias.

Phenylephrine reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

Antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation.

Co-administration of corticosteroids with phenylephrine increases the risk of developing glaucoma.

When used concomitantly with digoxin and cardiac glycosides, an increased risk of developing heart rhythm disturbances or heart attack is possible.

Ascorbic acid increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acid by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.

Ethanol contributes to the development of acute pancreatitis.

Myelotoxic drugs increase the hematotoxicity of the drug.

Overdose

In the event of an overdose of Caldrex® HotRem (even with good health), the risk of delayed signs of serious liver damage should be considered.

Symptoms caused by paracetamol: for 24 hours - pale skin, nausea, vomiting, anorexia, abdominal pain for 12-48 hours may show signs of impaired liver function, signs of impaired glucose metabolism and metabolic acidosis. Toxic effect in adults is possible after a single ingestion of more than 10 g of paracetamol - increased activity of hepatic transaminases, the clinical picture of liver damage manifests itself in 1-6 days. In the case of severe poisoning, severe hepatic insufficiency may develop up to hepatic encephalopathy, coma and death. Acute renal failure with acute tubal necrosis, which is diagnosed by severe lumbar pain, hematuria and proteinuria, can develop without severe liver dysfunction. There have been reports of cardiac arrhythmias and pancreatitis with an overdose of paracetamol.

In the early period, symptoms may be limited only by nausea and vomiting and may not reflect the severity of the overdose or the degree of risk of damage to the internal organs.

Treatment: In the first hour after the presumed overdose, the administration of activated charcoal is advisable. 4 or more hours after the presumed overdose, a determination of the plasma concentration of paracetamol is required (earlier determination of the paracetamol concentration may be unreliable). The specific antidote for paracetamol poisoning is acetylcysteine. Acetylcysteine ​​treatment can be performed up to 24 h after administration of paracetamol, however, the maximum hepatoprotective effect can be obtained within the first 8 h after overdose.

After that, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine ​​can be given in / in. In the absence of vomiting, the alternative (in the absence of the possibility of rapid receipt of inpatient care) is the appointment of methionine inside. Treatment of patients with severe liver dysfunction 24 hours after taking acetaminophen should be carried out in conjunction with specialists at the toxicology center or specialized department of liver diseases.

Symptoms caused by phenylephrine: irritability, headache, dizziness, insomnia, increase in blood pressure, nausea, vomiting, increased excitability, reflex bradycardia. In severe cases of overdose development of hallucinations, confusion, convulsions, arrhythmias is possible. An overdose with phenylephrine can cause symptoms similar to side effects.

Treatment: symptomatic therapy with severe hypertension using alpha-blockers such as phentolamine.

Symptoms caused by ascorbic acid: ascorbic acid in high doses (more than 3000 mg) can cause temporary osmotic diarrhea and gastrointestinal disorders such as nausea, stomach discomfort. Manifestations of ascorbic acid overdose can be categorized as those caused by severe liver damage as a result of paracetamol overdose.

Treatment: symptomatic, forced diuresis.

At the first signs of overdose, you should seek immediate medical attention, even in the absence of clear symptoms of poisoning.

Conditions for storage of

The temperature is not higher than 25 ° C.



Eczema, Thrush, burns, bedsores, stomatitis, pyoderma inflammation in the oral cavity, trophic ulcers Minor skin lesions, periodontitis, Trichomoniasis, wounds, dermatitis,

Active ingredient

Active ingredient

Paracetamol, Phenylephrine, Ascorbic acid

GlaxoSmithKline, UK



Coldrex HotRem with honey and lemon flavor sachets 5 g, 10 pcs. (Paracetamol, phenylephrine, ascorbic acid) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Coldrex HotRem with honey and lemon flavor sachets 5 g, 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.