Cyanocobalamin ampoules 500 mcg, 1 ml, 10 pcs. (tsianokobalamina)

Release form

Injection.

Packaging

In a package of 10 ampoules.

Pharmacological action

Cyanocobalamin exerts an erythrogenic, hematopoietic, antianemic, metabolic effect. High biological activity ensures the participation of cyanocobalamin in lipid, carbohydrate and protein metabolism. It stimulates the ability of tissues to regenerate, normalizes blood formation processes, functions of the nervous system and liver, activates the blood coagulation system, increases the activity of prothrombin and thromboplasts (in high doses), reduces blood cholesterol. In the body, it is transformed into a cofactor - cobamide (the active form of vitamin B12), which takes part in the transfer of methyl groups and other monocarbon fragments and is necessary for the formation of DNA and deoxyribose, methionine, creatine, choline. It accelerates the maturation of red blood cells, promotes the accumulation of compounds with sulfhydryl groups in them, thereby increasing their tolerance to hemolysis.

Cyanocobalamin is absorbed in the small (partly in the large) intestine, combining with an internal factor, it becomes protected from intestinal microflora. In the mucosa of the small intestine, the complex transfers vitamin B12 to the receptor, which carries it into the cell. In the blood, cyanocobalamin combines with transcobalamin I and II, with which it is transported to tissues. Cyanocobalamin is deposited mainly in the liver, excreted from the liver with bile into the intestine, from where it is again absorbed. Eliminated from the body by the kidneys. Penetrates through the placental barrier.

Indications

Cyanocobalamin is used in the treatment of chronic anemia with vitamin B12 deficiency (alimentary macrocytic anemia, Addison-Birmer disease), as part of the complex treatment of anemia (posthemorrhagic, iron deficiency, aplastic drugs), as well as toxic drugs, as well as anemic drugs, and also . It is used in the treatment of chronic hepatitis, cirrhosis of the liver, liver failure of alcoholism, prolonged fever polyneuritis, neuralgia (including trigeminal neuralgia), radiculitis. Vitamin B12 is prescribed in the treatment of funicular myelosis, malnutrition, peripheral nerve injuries, cerebral palsy, amyotrophic lateral sclerosis, Down's disease.

Cyanocobalamin is indicated for skin diseases: psoriasis, herpetiform dermatitis, photodermatitis, atopic dermatitis. Cyanocobalamin is also prescribed for radiation sickness, sprue, migraine, malignant neoplasms of the intestines and pancreas, for long-lasting infectious diseases, and kidney diseases. For the purpose of prevention when using PASK, biguanides and ascorbic acid in large doses, with pathology of the intestines and stomach with impaired absorption of vitamin B12 (resection of the small intestine, part of the stomach, Crohn's disease, malabsorption syndrome, celiac disease).

Contraindications

Cyanocobalamin is contraindicated for use in patients with hypersensitivity to the drug, erythremia, erythrocytosis, thromboembolism, pregnancy, breast-feeding.

Used with caution in angina pectoris, benign and malignant neoplasms, which are accompanied by vitamin B12 deficiency and megaloblastic anemia.

Use during pregnancy and lactation

There is some evidence of a possible teratogenic effect on the fetus of large doses of B vitamins, and therefore should not be used cyanocobalamin during pregnancy.

Special instructions

For angina pectoris, use with caution in a single dose of not more than 100 mcg. During treatment, the blood picture and coagulation should be regularly monitored.

Composition

1 ampoule contains: cyanocobalamin - 500 mcg.

Excipients: sodium chloride, water for injection.

Dosage and Administration

Cyanocobalamin is used subcutaneously, intramuscularly, intravenously and intralumbally.

In the treatment of Addison-Birmer disease, 100-200 micrograms per day every other day are prescribed for macrocytic anemia with neurological symptoms - 500 micrograms or more per administration (during the first week daily, then with 5-7 days between injections). In case of posthemorrhagic and iron deficiency anemia, Cyanocobalamin is prescribed at 30-100 mcg 3 times a week in the treatment of aplastic anemia - 100 mcg before clinical and hematological improvement. In the treatment of nutritional anemia in premature infants and young children, vitamin B12 is prescribed at 30 mcg per day for 15 days.

In case of neurological diseases and pathology of the central nervous system, 200-500 mcg is administered per injection, with a gradual increase in dosages, and when the condition improves, the dose is reduced to 100 mcg per day. The course of therapy is 2 weeks.

In traumatic lesions of the peripheral nerves, Cyanocobalamin is used at 200-400 mcg every other day for 45 days.

With cirrhosis and hepatitis - 30-60 mcg daily or 100 mcg every other day. Therapy is designed for 25-40 days.

With Down's disease, dystrophy in children, cerebral palsy - 15-30 mcg every other day.

In the treatment of amyotrophic lateral sclerosis, funicular myelosis, multiple sclerosis, cyanocobalamin can be administered intralumbally at 15-30 micrograms with increasing dosages up to 250 micrograms.

Side effects

From the central nervous system: rarely - a state of arousal.

From the cardiovascular system: rarely - pain in the heart, tachycardia.

Allergic reactions: rarely - urticaria.

Drug Interactions

Cyanocobalamin is pharmaceutically incompatible with ascorbic acid, riboflavin, and heavy metal salts. Salicylates, antiepileptic drugs, aminoglycosides, colchicine reduce the absorption of cyanocobalamin. Vitamin B12 should not be combined with drugs that enhance blood coagulation. Incompatible in the same syringe with vitamins B6 and B1. Cyanocobalamin is able to enhance allergic manifestations caused by vitamins B1.

Storage conditions

In a dark place.

Expiration

2 years.

Active ingredient

Cyanocobalamin

Conditions of release from drugstores

Prescription

dosage form

solution for injection

Indications

From hypov Algal ternary nerve, From hepatitis, From bleeding, From Crohn's disease, From anemia, From neuritis, From alcoholism, From radiculitis, In case of liver damage, Dermatitis, From psoriasis

Possible product names

Cyanocobalamin ampoules 500 mcg, 1 ml, 10 pcs.

CYANOCOBALAMINE RR D / IN. 0.5 MG / ML AMP. 1ML No. 10

Yerevan HFF, Armenia



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