Desloratadine Canon tablets coated. 5 mg 10 pcs. (deslor atadine)

Latin name

DESLORATADINE CANON

Release form

Film-coated tablets of white or almost white color, round, biconvex in cross section of almost white or white with a creamy or white with a pinkish tint.



packaging 10 pcs

Pharmacological action

Pharmaceutical group: antiallergic drug - H1-histamine receptor blocker. Srdlp Pharmaceutical action:

Desloratadine Canon is a long-acting antihistamine

is the primary active metabolite of loratadine and inhibits a cascade of allergic inflammation reactions, including the release of inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, the release of pro-inflammatory chemokines (RANTES), production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, isolation of adhesion molecules such as P-selectin, IgE-mediated release of histamine, prostaglandin D2 and leukotriene C4.

Thus, it prevents the development and facilitates the course of allergic reactions, has an antipruritic and antiexudative effect, reduces capillary permeability, prevents the development of tissue edema, smooth muscle spasm.

The drug does not affect the central nervous system, practically does not have a sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions. Does not cause prolongation of the QT interval on the ECG.

Desloratadine begins within 30 minutes after ingestion and lasts 24 hours.

Pharmacokinetics: Only a small portion of the oral dose is excreted by the kidneys (<2%) and through the intestines (<7%). The elimination half-life is 20-30 hours (on average - 27 hours).

Indications

- Allergic rhinitis (elimination or relief of sneezing, nasal congestion, nasal mucus, itching in the nose, itching of the palate, itching and redness of the eyes, lacrimation)

- urticaria (reduction or elimination of skin itching, rash).

Contraindications

- Hypersensitivity to any of the substances that make up the

preparation - pregnancy and lactation

- under the age of 12 years.

Precautions: Severe chronic renal failure.

Use during pregnancy and lactation

The drug Desloratadine Canon is not recommended for use during pregnancy, as there have been no clinical trials and the safety of use during pregnancy has not been established.

Desloratadine passes into breast milk, therefore, women who are breast-feeding should not take Desloratadine Canon.

Composition of

1 tablet: - desloratadine 5 mg

excipients:

calcium hydrogen phosphate dihydrate 61.7 mg

povidone 6.8 mg

calcium stearate 0.7 mg croscarmellose sodium

(primrose 4) 8 mg

microcrystalline cellulose 41 mg

film composition:

Opadry II white 4 mg, including: 1.88 mg polyvinyl alcohol, macrogol (polyethylene glycol 3350) 0.94 mg, talc 0.7 mg, titanium dioxide 0, 48 mg

Dosage and administration

Inside, regardless of food intake, adults and adolescents from 12 years old 1 tablet per day. The tablet should be swallowed whole, washed down with water.

Side effects

WHO classification of the incidence of side effects: very often - 1/10 prescriptions (> 10%)

often - from 1/100 to <1/10 prescriptions (> 1% and infrequently from 1 / 1000 to 0.1% and rarely - from 1/10000 to 0.01% and very rare - Disorders from the

immune system Very rarely: allergic reactions, including anaphylaxis.

Disorders from the nervous system

Infrequently: headache.

Disorders from heart

Very rare: tachycardia, palpitations

Disorders of the gastrointestinal tract

Infrequently: dry mouth.

Disorders of the skin and subcutaneous tissue

Very rare: rash.

General disorders and disorders at the injection site

Often: fatigue.

Laboratory and instrumental data

Very rare: increased activity of liver enzymes, increased bilirubin concentration.

Drug Interaction

No interaction with other drugs. Eating does not affect the effectiveness of the drug. Desloratadine does not increase the effect of alcohol on the central nervous system.

Active ingredient

Desloratadine

Conditions of dispensation from pharmacies

By retseptu

lekarstvennaja form

tablets

Indications

Indications

Dermatitis, Allergic conjunctivitis, Diathesis, Allergic rhinitis, Allergy, Urticaria, Pollinosis

Kanonfarma, Russia



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