Diacarb tablets 250 mg, 30 pcs. (acetazolamide)

Description

White tablets, round, biconvex.

Indications

edematous syndrome (mild or moderate, combined with alkalosis) relief of an acute attack of glaucoma, preoperative preparation of patients, persistent cases of the course of glaucoma (in complex therapy) with epilepsy as an additional therapy for antiepileptic drugs, acute altitude sickness (the drug reduces acclimatization time), liquorodynamic disturbances, intracranial hypertension (benign intracranial hypertension, intracranial hypertension after ventricular bypass surgery) in complex therapy.

Contraindications

acute renal failure uremia liver failure (risk of encephalopathy) hypokalemia hyponatremia metabolic acidosis hypocorticism Addison's disease diabetes mellitus I trimester of pregnancy lactation infant age up to 3 years hypersensitivity to the components of the drug. With caution: hepatic and renal edema, simultaneous administration with acetylsalicylic acid (doses greater than 300 mg / day), pulmonary embolism and emphysema (risk of acidosis), II and III trimesters of pregnancy.

Recommendations for use

The drug is taken orally, strictly as directed by a doctor. In case of skipping the drug, the next dose should not be increased. Edema syndrome At the beginning of treatment, 250 mg is taken in the morning. To achieve the maximum diuretic effect, it is necessary to take DiacarbВ® 1 time / day every other day or 2 days in a row with a one-day break. Increasing the dose does not enhance the diuretic effect. Glaucoma DiacarbВ® should be taken as part of complex therapy. For adults with open-angle glaucoma, the drug is prescribed in a dose of 250 mg 1-4 times / day. Doses exceeding 1000 mg do not increase the therapeutic effect. In secondary glaucoma, the drug is prescribed in a dose of 250 mg every 4 hours during the day. In some patients, the therapeutic effect is manifested after a short-term administration of the drug at a dose of 250 mg 2 times / day. In acute attacks of glaucoma - 250 mg 4 times / day. Children older than 3 years with glaucoma attacks - 10-15 mg / kg body weight / day in 3-4 doses. After 5 days of admission, take a break for 2 days. With prolonged treatment, it is necessary to prescribe potassium preparations, a potassium-sparing diet. In preparation for the operation, 250-500 mg are prescribed on the eve and in the morning on the day of the operation. Epilepsy Doses for adults: 250-500 mg / day in 1 dose for 3 days, on the 4th day a break. With the simultaneous use of acetazolamide with other anticonvulsants, 250 mg 1 time / day is used at the beginning of treatment, gradually increasing the dose if necessary. Doses for children over 3 years: 8-30 mg / kg / day, divided into 1-4 doses. The maximum daily dose is 750 mg. Acute altitude sickness Recommended use of the drug at a dose of 500-1000 mg / day. In the case of rapid ascent - 1000 mg / day. The drug should be used 24-48 hours before climbing. In case of symptoms of the disease, treatment is continued for the next 48 hours or longer, if necessary. Liquorodynamic disturbances, intracranial hypertension. The use of the drug at a dose of 250 mg / day or 125-250 mg every 8-12 hours is recommended. The maximum therapeutic effect is achieved with a dose of 750 mg / day. To achieve the optimal therapeutic effect, daily non-interval administration of the drug may be required.

Special instructions

If you are hypersensitive to the drug, life-threatening side effects may appear, such as Stevens-Johnson syndrome, Lyell syndrome, fulminant liver necrosis, agranulocytosis, aplastic anemia and hemorrhagic diathesis. In case of manifestation of these symptoms, you should immediately stop taking the drug. Diacarb®, used in doses exceeding the recommended, does not increase diuresis, can increase drowsiness and paresthesia, and sometimes also reduce diuresis. The drug can cause acidosis, therefore, it should be used with caution in patients with pulmonary embolism and pulmonary emphysema. The drug alkalizes urine. Diacarb® should be used with caution in patients with diabetes mellitus due to the increased risk of hyperglycemia. In case of administration for more than 5 days, the risk of developing metabolic acidosis is high. It is recommended to monitor the blood picture and platelets at the beginning of treatment and at regular intervals during treatment, as well as periodic monitoring of electrolytes in the blood serum. The effect on the ability to drive vehicles and control the mechanisms of Diakarb®, especially in high doses, can cause drowsiness, less often fatigue, dizziness, ataxia and disorientation, therefore, during treatment, patients should not drive vehicles and work with mechanisms, requiring increased concentration of attention and speed of psychomotor reactions.

Composition

1 tab. acetazolamide 250 mg Excipients: microcrystalline cellulose - 80.76 mg, povidone - 8.64 mg, colloidal silicon dioxide - 1.8 mg, croscarmellose sodium - 7 mg, magnesium stearate - 1.8 mg.

Side effects

Adverse effects are classified according to frequency of occurrence and according to organs and systems. The following definition of the frequency of occurrence of undesirable effects is accepted: very often (> 1/10) often (> 1/100, <1/10) infrequently (> 1/1000, <1/100) rarely (> 1/10 000, <1 / 1000) is very rare (<1/10 000), the frequency is unknown (cannot be determined based on available data). From the hemopoietic system: rarely - aplastic anemia, thrombocytopenia, agranulocytosis, leukopenia, thrombocytopenic purpura, myelosuppression, pancytopenia. From the immune system: the frequency is unknown - anaphylactic reactions. From the side of metabolism and nutrition: often - loss of appetite, taste disturbances, metabolic acidosis, metabolic acidosis and electrolyte disturbances (usually can be adjusted by prescribing bicarbonate) infrequently - thirst rarely - glucosuria frequency is unknown - hypokalemia, hyponatremia. Mental disorders: infrequently - depression, irritability, frequency unknown - agitation, confusion, disorientation. From the nervous system: often - dizziness, paresthesia, in particular, tingling sensations in the extremities infrequently - hot flashes, headache very rarely - drowsiness, peripheral paresis, convulsions, frequency is unknown - ataxia. From the side of the organ of vision: rarely - transient myopia (this condition completely disappeared with a dose reduction or drug withdrawal). On the part of the hearing organ: rarely - hearing impairment and ringing in the ears. From the digestive system: infrequently - nausea, vomiting, diarrhea, melena rarely - fulminant liver necrosis, impaired liver function, hepatitis, cholestatic jaundice, frequency is unknown - dry mouth, dysgeusia, liver failure, hepatic colic. On the part of the skin and subcutaneous tissue: rarely - photosensitization, frequency unknown - itching, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. From the musculoskeletal system: the frequency is unknown - arthralgia. From the urinary system: the frequency is unknown - the formation of calculi in the kidneys, crystalluria, renal and ureteric colic and kidney damage, polyuria, hematuria, renal failure. From the genitals and mammary gland: infrequently - decreased libido. General disorders and disorders at the injection site: often - fatigue infrequently - fever, weakness.

Drug Interactions

Acetazolamide may enhance the effects of folic acid antagonists, hypoglycemic agents, and oral anticoagulants. The simultaneous use of acetazolamide and acetylsalicylic acid can cause metabolic acidosis and enhance toxic effects on the central nervous system. When combined with cardiac glycosides or drugs that increase blood pressure, the dose of acetazolamide should be adjusted. Acetazolamide increases the content of phenytoin in the blood serum. Acetazolamide enhances the manifestations of osteomalacia caused by antiepileptic drugs. The simultaneous use of acetazolamide and amphetamine, atropine or quinidine can enhance their side effect. Potentiation of the diuretic effect occurs when combined with methylxanthines (aminophylline). A decrease in the diuretic effect occurs when combined with ammonium chloride and other acid-forming diuretics. An increase in the hypotensive effect with respect to intraocular pressure is possible with simultaneous use with cholinergic drugs and beta-blockers. Acetazolamide enhances the effects of ephedrine. Increases the concentration in the blood plasma of carbamazepine, non-depolarizing muscle relaxants. Increases lithium excretion.

Overdose

Overdose symptoms not described. Possible symptoms of an overdose may be disturbances in the water-electrolyte balance, metabolic acidosis, as well as disorders of the central nervous system. Treatment: there is no specific antidote. Symptomatic and supportive therapy is performed. It is necessary to control the content of electrolytes in the blood, especially potassium, sodium, as well as blood pH. In the case of metabolic acidosis, sodium bicarbonate is used. Acetazolamide is excreted by hemodialysis.

Storage conditions

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.

Expiration

5 years. Do not use the product after the expiry date.

Form of Treatment

tablets



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