Diclofenac (Diclofenac)

Release form

Tablets retard.

Packing

20 pcs.

Pharmacological action

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects. It inhibits the COX enzyme in the cascade of arachidonic acid metabolism and disrupts the biosynthesis of prostaglandins.

When used externally, it has anti-inflammatory and analgesic effects. Reduces and relieves pain at the site of ointment application (including joint pain at rest and during movement), reduces morning stiffness and swelling of joints. Helps increase range of motion.

Indications

1. Inflammatory and inflammation-activated degenerative forms of rheumatism:

- chronic polyarthritis

- ankylosing spondylitis (Ankylosing spondylitis)

- arthrosis

- spondylarthrosis, neuromus lupus, irrigation, -

- acute attacks of gout.

2. Rheumatic lesions of the soft tissues.

3. Painful swelling or inflammation after trauma or surgery.

4. Non-rheumatic inflammatory pain conditions.

Contraindications

- pathological changes in the blood picture of unclear genesis

- peptic ulcer of the stomach and duodenum

- destructive and inflammatory bowel disease in the acute phase

- pregnancy

- lactation and lactation 12 years (i / m administration, supp.)

- children under 6 years of age (tablets, ointment)

- hypersensitivity to acetylsalicylic acid or other NSAIDs (including the aspirin triad)

- increased sensitivity to diclofenac and other components of the drug

- inflammation of the rectum - proctitis (suppositories).

Diclofenac may be taken only under strict medical supervision after a careful assessment of the benefit / risk ratio in the following conditions: congenital hematopoiesis (induced by porphyria) systemic lupus erythematosus and other systemic diseases of the connective tissue, complaints of gastrointestinal function, or suspected stomach ulcer or duodenal ulcer, as well as with erosive-ulcerative lesions (ulcerative colitis, Crohn's disease) in patients with previous kidney disease and / or severe arusheniyami liver function in severe hypertension and / or heart failure in elderly patients immediately after surgery.

Special instructions

Use with caution the drug at the same time as other NSAIDs.

Effect on the ability to drive a car and control mechanisms

Due to the fact that when using the drug in high doses, side effects such as dizziness and a feeling of fatigue may develop, in some cases the ability to drive a car or other moving objects is impaired. These phenomena are amplified while taking alcohol.

Composition

1 tablet contains

diclofenac sodium 100 mg

excipients:

ludipress,

hydroxypropylmethyl cellulose,

magnesium stearic acid,

sicl, alkylene glycerol acid, srldolp

Dosage and administration

Inside, without chewing, before, during or after meals, with a little water.

Adults - 100 mg once a day. With dysmenorrhea and migraine attacks - up to 200 mg / day. When taking 100 mg of retard, if necessary, increase the daily dose to 150 mg / day, you can additionally take 1 regular tablet (50 mg). The maximum daily dose of 150 mg.

Side effects

Side effects depend on the individual sensitivity, the size of the dose used and the duration of treatment.

From the digestive system: nausea, vomiting, epigastric pain, anorexia, flatulence, constipation, gastritis up to erosive with bleeding, increased transaminase activity, drug hepatitis, pancreatitis.

Urinary system: interstitial nephritis.

From the side of the central nervous system: headache, dizziness, disorientation, agitation, insomnia, irritability, fatigue, aseptic meningitis.

From the respiratory system: bronchospasm.

From the hematopoietic system: anemia, thrombocytopenia, leukopenia, agranulocytosis.

Dermatological reactions: exanthema, erythema, eczema, hyperemia, erythroderma, photosensitivity.

Allergic reactions: erythema multiforme, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic reactions, including shock.

Other: fluid retention, edema, increased blood pressure.

Drug interaction

With the simultaneous use of the drug Diclofenac with digoxin, phenytoin or lithium drugs, it is possible to increase plasma concentrations of these drugs with diuretics and hypotensive drugs may decrease the effects of hypotensive drugs hyperkalemia with acetylsalicylic acid - a decrease in the concentration of diclofenac in blood plasma and an increased risk of developing tions of side effects.

Diclofenac may enhance the toxic effects of cyclosporine on the kidneys.

Diclofenac can cause hypo- or hyperglycemia, therefore, when used simultaneously with hypoglycemic agents, monitoring of blood glucose concentration is required.

When methotrexate is used within 24 hours before or after taking Diclofenac, an increase in the concentration of methotrexate and an increase in its toxic effect are possible.

With simultaneous use with anticoagulants, regular monitoring of blood coagulation is necessary.

Overdose

Symptoms: dizziness, headache, hyperventilation of the lungs, clouding of consciousness, vomiting, bleeding from the digestive tract, diarrhea, tinnitus, convulsions, with significant overdose - acute renal failure, hepatotoxic effect.

Treatment: gastric lavage, intake of activated carbon. Symptomatic therapy is aimed at eliminating the increase in blood pressure, impaired renal function, seizures, gastrointestinal irritation, respiratory depression. Forced diuresis, hemodialysis are ineffective (due to a significant connection with proteins and intense metabolism).

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 C.



pharmacy terms with prescription

Dosage form

tablet prolong.



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