Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. (Fluconazole)
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$26.35
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$31.00
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Latin name
Diflucan Buy Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. (Fluconazole) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Diflucan Buy Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. (Fluconazole) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
Diflucan
Release form
Powder for preparing an oral suspension
Packaging
60 ml vial (ready-made suspension volume 35 ml).
Indications of
cryptococcosis, including cryptococcal meningitis and infections of a different location (e.g. lungs, skin), including in patients with a normal immune response and AIDS patients, recipients of transplanted organs and patients with other forms of immunodeficiency, maintenance therapy for the prevention of relapse of cryptococcosis in AIDS patients
generalized candidiasis, including candidiasis, disseminated candidiasis and other forms of invasive candida infection, such as peritoneal infections, endocardium, eyes, respiratory and urinary tracts, including in patients with malignant tumors, located in intensive care units and receiving cytotoxic or immunosuppressive drugs, as well as in patients with other factors predisposing to the development of candidiasis
candidiasis of the mucous membranes, including mucous membranes of the mouth and pharynx, esophagus, non-invasive broncho-pulmonary infections, candiduria, mucocutaneous and chronic atrophic candidiasis of the oral cavity (associated with the wearing of dentures), including in patients with normal and suppressed immune function, prevention of recurrence of oropharyngeal candidiasis in AIDS patients
genital candidiasis acute or recurrent vaginal candidiasis prevention to reduce the frequency of relapse of vaginal candidiasis (3 or more episodes per year) candidal balanitis
prevention of fungal infections in patients with malignant , predisposed to such infections as a result of cytotoxic chemotherapy or radiation therapy for
mycoses of the skin, including mycoses of the feet, body, inguinal region, pityriasis versicolor, onychomycosis and skin candidal infections
deep endemic mycoses in patients with normal immunity, coccidioidomycosis, paracosis.
Contraindications
hypersensitivity to fluconazole, other components of the drug or azole substances, simultaneous administration of terfenadine at a dose of 400 mg / day or more, drugs that increase the QT interval and are metabolized by the isoenzyme CYP3A4 sucrose deficiency, isomaltose metabolism, and glucose isomaltose metabolism.
Caution: impaired liver function indicators impaired renal function
rash on the background of fluconazole in patients with superficial fungal infection and invasive / systemic fungal infections, the simultaneous use of terfenadine and fluconazole in a dose of less than 400 mg / day potentially proarrhythmic conditions in patients with multiple risk factors (organic diseases heart, electrolyte imbalance and concomitant therapy conducive to the development of such disorders).
Fluconazole should be avoided during pregnancy, except in cases of severe and potentially life-threatening fungal infections, when the expected benefits of the treatment outweigh the potential risk to the fetus.
During breastfeeding, fluconazole is not recommended.
Use during pregnancy and lactation
Fluconazole should be avoided during pregnancy, except in cases of severe and potentially life-threatening fungal infections, when the expected benefits of the treatment outweigh the potential risk to the fetus.
Fluconazole is found in breast milk at the same concentrations as in the blood, therefore, Diflucan is not recommended for use during lactation (breastfeeding).
Composition
1 ml of the finished suspension contains:
active substance: fluconazole 10 mg or 40 mg respectively
excipients: citric acid anhydrous 4.20 mg / 4.21 mg, sodium benzoate 2.37 mg / 2.38 mg, xanthan gum 2.03 mg / 2.01 mg, titanium dioxide (E 171) 1.0 mg / 0.98 mg, sucrose 576.23 mg / 546.27 mg, colloidal silicon dioxide anhydrous 1.0 mg / 0, 98 mg, sodium citrate dihydrate 3.17 mg / 3.17 mg, orange flavor * 10.0 mg / 10.0 mg.
* contains orange essential oil, maltodextrin and water.
Side effects
Drug tolerance is usually very good.
In clinical and post-marketing (*) studies of Diflucan®, the following adverse reactions were noted:
From the nervous system: headache, dizziness *, cramps *, taste change *, paresthesia, insomnia, drowsiness, tremor.
From the digestive system: abdominal pain, diarrhea, flatulence, nausea, dyspepsia *, vomiting *, dry oral mucosa, constipation.
From the hepatobiliary system: hepatotoxicity, in some cases fatal, increased concentration of bilirubin, serum activity of aminotransferases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), alkaline phosphatase, impaired liver function *, hepatitis *, hepatocellular necrosis *, jaundice *, cholestasis, hepatocellular damage.
From the skin: rash, alopecia *, exfoliative skin lesions *, including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous abscess, increased sweating, drug rash.
From the hemopoietic organs and lymphatic system *: leukopenia, including neutropenia and agranulocytosis, thrombocytopenia, anemia.
On the part of the immune system *: anaphylaxis (including angioedema, swelling of the face, urticaria, pruritus).
From the cardiovascular system *: an increase in the QT interval on the ECG, ventricular tachysystolic arrhythmia, type “pirouette” arrhythmia.
Metabolic *: increased plasma cholesterol and triglycerides, hypokalemia.
From the musculoskeletal system: myalgia. Tolerance to the drug is usually very good.
In clinical and post-marketing (*) studies of Diflucan®, the following adverse reactions were noted:
From the nervous system: headache, dizziness *, cramps *, taste change *, paresthesia, insomnia, drowsiness, tremor.
From the digestive system: abdominal pain, diarrhea, flatulence, nausea, dyspepsia *, vomiting *, dry oral mucosa, constipation.
From the hepatobiliary system: hepatotoxicity, in some cases fatal, increased concentration of bilirubin, serum activity of aminotransferases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), alkaline phosphatase, impaired liver function *, hepatitis *, hepatocellular necrosis *, jaundice *, cholestasis, hepatocellular damage.
From the skin: rash, alopecia *, exfoliative skin lesions *, including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous abscess, increased sweating, drug rash.
From the hemopoietic organs and lymphatic system *: leukopenia, including neutropenia and agranulocytosis, thrombocytopenia, anemia.
On the part of the immune system *: anaphylaxis (including angioedema, swelling of the face, urticaria, pruritus).
From the cardiovascular system *: an increase in the QT interval on the ECG, ventricular tachysystolic arrhythmia, type “pirouette” arrhythmia.
Metabolism *: increased plasma cholesterol and triglycerides, hypokalemia.
From the musculoskeletal system: myalgia.
Drug Interaction
Anticoagulants. Like other antifungal agents - azole derivatives, fluconazole, when used with warfarin, increases PV (by 12%), in connection with which the development of bleeding (hematoma, bleeding from the nose and gastrointestinal tract, hematuria, melena) is possible. Patients receiving coumarin anticoagulants should be monitored continuously for PV.
Azithromycin. When co-administered with fluconazole at a single dose of 800 mg with azithromycin at a single dose of 1200 mg expressed pharmacokinetic interaction between both drugs has not been established.
Benzodiazepines (short acting). After ingestion of midazolam, fluconazole significantly increases the concentration of midazolam and psychomotor effects, and this effect is more pronounced after fluconazole ingestion than when administered intravenously. If concomitant benzodiazepine therapy is required, patients receiving fluconazole should be monitored for the appropriate dose reduction of benzodiazepine.
Cisapride. With the concomitant use of fluconazole and cisapride, adverse reactions from the heart are possible, including: fluttering / fluttering of the ventricles (torsade de pointРs). The use of fluconazole at a dose of 200 mg once daily and cisapride at a dose of 20 mg 4 times a day leads to a marked increase in plasma concentrations of cisapride and an increase in the QT interval on the ECG. Co-administration of cisapride and fluconazole is contraindicated.
Cyclosporine. In patients with transplanted kidney, the use of fluconazole at a dose of 200 mg / day leads to a slow increase in the concentration of cyclosporine. However, with repeated administration of fluconazole at a dose of 100 mg / day, no change in the concentration of cyclosporine in bone marrow recipients was observed. With the use of fluconazole and cyclosporine, it is recommended to monitor the concentration of cyclosporine in the blood.
Hydrochlorothiazide. Repeated administration of hydrochlorothiazide with fluconazole leads to an increase in plasma fluconazole concentration by 40%. The effect of this degree of severity does not require changing the dosage regimen of fluconazole in patients receiving diuretics at the same time, howeverto consider.
Oral contraceptives. Concomitant use of combined oral contraceptive with fluconazole at a dose of 50 mg has no significant effect on the level of hormones, while the daily intake of 200 mg of fluconazole AUC of ethinylestradiol and levonorgestrel increase by 40 and 24%, respectively, and when receiving 300 mg of fluconazole The AUC of ethinyl estradiol and norethindrone increased by 24 and 13%, respectively. Thus, repeated use of fluconazole at these doses is unlikely to have an effect on the effectiveness of combination oral contraceptives.
Phenytoin. Concomitant administration of fluconazole and phenytoin may be accompanied by a clinically significant increase in phenytoin concentration. If both drugs are to be used concomitantly, phenytoin concentration should be monitored and dose adjusted accordingly to ensure serum therapeutic concentration.
Rifabutin. Concomitant use of fluconazole and rifabutin may increase serum concentrations of the latter. When fluconazole and rifabutin are used concomitantly, cases of uveitis have been reported. Patients receiving rifabutin and fluconazole should be closely monitored.
Rifampicin. Concomitant administration of fluconazole and rifampicin results in a 25% reduction in AUC and a fluconazole duration of T1 / 2 by 20%. Patients taking rifampicin at the same time should consider the feasibility of increasing the dose of fluconazole.
Sulfonylureas. Fluconazole, co-administered, leads to an increase in T1 / 2 oral preparations of sulfonylurea (chlorpropamide, glibenclamide, glipizide and tolbutamide). Patients with diabetes can be prescribed the combined use of fluconazole and oral preparations of sulfonylurea, but the possibility of developing hypoglycemia should be considered.
Tacrolimus. Concomitant use of fluconazole and tacrolimus leads to an increase in serum concentrations of the latter. Cases of nephrotoxicity are described. Patients receiving both tacrolimus and fluconazole should be closely monitored.
Terfenadine. With the use of azole antifungal agents and terfenadine, serious arrhythmias may occur as a result of increasing the QT interval. No increase in QT interval was observed with fluconazole 200 mg / day, however, the use of fluconazole at doses of 400 mg / day and above causes a significant increase in the plasma concentrations of terfenadine. Concomitant administration of fluconazole at doses of 400 mg / day or more with terfenadine is contraindicated (see Contraindications section). Fluconazole treatment at doses less than 400 mg / day in combination with terfenadine should be closely monitored.
Theophylline. When co-administered with fluconazole at a dose of 200 mg for 14 days, the average plasma clearance rate of theophylline is reduced by 18%. When fluconazole is given to patients receiving theophylline at high doses or to patients at increased risk of theophylline toxicity, the symptoms of theophylline overdose should be monitored and, if necessary, adjusted.
Zidovudine. When co-administered with fluconazole, there is an increase in concentrations of zidovudine, which is probably due to a decrease in the metabolism of the latter to its major metabolite. A significant increase in zidovudine AUC (20%) was found before and after treatment with fluconazole at 200 mg / d for 15 days in patients with AIDS and ARC (AIDS-related complex).
When administered to HIV-infected patients, zidovudine at a dose of 200 mg every 8 h for 7 days in combination with or without fluconazole at a dose of 400 mg / day showed a significant increase in zidovudine AUC (74%) between the two regimens. when co-administered with fluconazole. Patients receiving this combination should be observed to identify side effects of zidovudine.
Concomitant use of fluconazole with astemizole or other drugs metabolised by the cytochrome P450 system may be accompanied by increased serum concentrations of these agents. Caution should be exercised when fluconazole is administered concomitantly in the absence of reliable information. Patients should be carefully observed.
Studies on the interaction of oral forms of fluconazole with its concomitant administration with food, cimetidine, antacids, as well as after total body irradiation to prepare for bone marrow transplantation have shown that these factors do not have a clinically relevant effect on the absorption of fluconazole.
These interactions have been established with repeated use of fluconazole to interact with drugs as a result of single administration of fluconazole.
Doctors should note that interaction with other drugs has not been specifically studied, but it is possible.
overdose
Symptoms: fluconazole overdose has been reported, and in one case, a 42-year-old HIV-infected patient had hallucinations and paranoid behavior after taking 8200 mg of the drug. The patient was hospitalized and his condition normalized within 48 hours.
Treatment: symptomatic treatment (including supportive measures and gastric lavage).
Fluconazole is excreted mainly in the urine, so forced diuresis can probably accelerate the excretion of the drug. A 3-hour hemodialysis session reduces plasma fluconazole levels by about 50%.
Storage conditions
The drug should be stored at a temperature not exceeding 30 ° C, out of the reach of children.
Expiration
3 years.
Use the finished suspension for 14 days.
Do not use after the expiry date stated on the packaging.
Deystvuyuschee substances
Fluconazole
Cond Ovia pharmacy vacation
Prescription
Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. (Fluconazole) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Diflucan
Release form
Powder for preparing an oral suspension
Packaging
60 ml vial (ready-made suspension volume 35 ml).
Indications of
cryptococcosis, including cryptococcal meningitis and infections of a different location (e.g. lungs, skin), including in patients with a normal immune response and AIDS patients, recipients of transplanted organs and patients with other forms of immunodeficiency, maintenance therapy for the prevention of relapse of cryptococcosis in AIDS patients
generalized candidiasis, including candidiasis, disseminated candidiasis and other forms of invasive candida infection, such as peritoneal infections, endocardium, eyes, respiratory and urinary tracts, including in patients with malignant tumors, located in intensive care units and receiving cytotoxic or immunosuppressive drugs, as well as in patients with other factors predisposing to the development of candidiasis
candidiasis of the mucous membranes, including mucous membranes of the mouth and pharynx, esophagus, non-invasive broncho-pulmonary infections, candiduria, mucocutaneous and chronic atrophic candidiasis of the oral cavity (associated with the wearing of dentures), including in patients with normal and suppressed immune function, prevention of recurrence of oropharyngeal candidiasis in AIDS patients
genital candidiasis acute or recurrent vaginal candidiasis prevention to reduce the frequency of relapse of vaginal candidiasis (3 or more episodes per year) candidal balanitis
prevention of fungal infections in patients with malignant , predisposed to such infections as a result of cytotoxic chemotherapy or radiation therapy for
mycoses of the skin, including mycoses of the feet, body, inguinal region, pityriasis versicolor, onychomycosis and skin candidal infections
deep endemic mycoses in patients with normal immunity, coccidioidomycosis, paracosis.
Contraindications
hypersensitivity to fluconazole, other components of the drug or azole substances, simultaneous administration of terfenadine at a dose of 400 mg / day or more, drugs that increase the QT interval and are metabolized by the isoenzyme CYP3A4 sucrose deficiency, isomaltose metabolism, and glucose isomaltose metabolism.
Caution: impaired liver function indicators impaired renal function
rash on the background of fluconazole in patients with superficial fungal infection and invasive / systemic fungal infections, the simultaneous use of terfenadine and fluconazole in a dose of less than 400 mg / day potentially proarrhythmic conditions in patients with multiple risk factors (organic diseases heart, electrolyte imbalance and concomitant therapy conducive to the development of such disorders).
Fluconazole should be avoided during pregnancy, except in cases of severe and potentially life-threatening fungal infections, when the expected benefits of the treatment outweigh the potential risk to the fetus.
During breastfeeding, fluconazole is not recommended.
Use during pregnancy and lactation
Fluconazole should be avoided during pregnancy, except in cases of severe and potentially life-threatening fungal infections, when the expected benefits of the treatment outweigh the potential risk to the fetus.
Fluconazole is found in breast milk at the same concentrations as in the blood, therefore, Diflucan is not recommended for use during lactation (breastfeeding).
Composition
1 ml of the finished suspension contains:
active substance: fluconazole 10 mg or 40 mg respectively
excipients: citric acid anhydrous 4.20 mg / 4.21 mg, sodium benzoate 2.37 mg / 2.38 mg, xanthan gum 2.03 mg / 2.01 mg, titanium dioxide (E 171) 1.0 mg / 0.98 mg, sucrose 576.23 mg / 546.27 mg, colloidal silicon dioxide anhydrous 1.0 mg / 0, 98 mg, sodium citrate dihydrate 3.17 mg / 3.17 mg, orange flavor * 10.0 mg / 10.0 mg.
* contains orange essential oil, maltodextrin and water.
Side effects
Drug tolerance is usually very good.
In clinical and post-marketing (*) studies of Diflucan®, the following adverse reactions were noted:
From the nervous system: headache, dizziness *, cramps *, taste change *, paresthesia, insomnia, drowsiness, tremor.
From the digestive system: abdominal pain, diarrhea, flatulence, nausea, dyspepsia *, vomiting *, dry oral mucosa, constipation.
From the hepatobiliary system: hepatotoxicity, in some cases fatal, increased concentration of bilirubin, serum activity of aminotransferases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), alkaline phosphatase, impaired liver function *, hepatitis *, hepatocellular necrosis *, jaundice *, cholestasis, hepatocellular damage.
From the skin: rash, alopecia *, exfoliative skin lesions *, including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous abscess, increased sweating, drug rash.
From the hemopoietic organs and lymphatic system *: leukopenia, including neutropenia and agranulocytosis, thrombocytopenia, anemia.
On the part of the immune system *: anaphylaxis (including angioedema, swelling of the face, urticaria, pruritus).
From the cardiovascular system *: an increase in the QT interval on the ECG, ventricular tachysystolic arrhythmia, type “pirouette” arrhythmia.
Metabolic *: increased plasma cholesterol and triglycerides, hypokalemia.
From the musculoskeletal system: myalgia. Tolerance to the drug is usually very good.
In clinical and post-marketing (*) studies of Diflucan®, the following adverse reactions were noted:
From the nervous system: headache, dizziness *, cramps *, taste change *, paresthesia, insomnia, drowsiness, tremor.
From the digestive system: abdominal pain, diarrhea, flatulence, nausea, dyspepsia *, vomiting *, dry oral mucosa, constipation.
From the hepatobiliary system: hepatotoxicity, in some cases fatal, increased concentration of bilirubin, serum activity of aminotransferases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), alkaline phosphatase, impaired liver function *, hepatitis *, hepatocellular necrosis *, jaundice *, cholestasis, hepatocellular damage.
From the skin: rash, alopecia *, exfoliative skin lesions *, including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous abscess, increased sweating, drug rash.
From the hemopoietic organs and lymphatic system *: leukopenia, including neutropenia and agranulocytosis, thrombocytopenia, anemia.
On the part of the immune system *: anaphylaxis (including angioedema, swelling of the face, urticaria, pruritus).
From the cardiovascular system *: an increase in the QT interval on the ECG, ventricular tachysystolic arrhythmia, type “pirouette” arrhythmia.
Metabolism *: increased plasma cholesterol and triglycerides, hypokalemia.
From the musculoskeletal system: myalgia.
Drug Interaction
Anticoagulants. Like other antifungal agents - azole derivatives, fluconazole, when used with warfarin, increases PV (by 12%), in connection with which the development of bleeding (hematoma, bleeding from the nose and gastrointestinal tract, hematuria, melena) is possible. Patients receiving coumarin anticoagulants should be monitored continuously for PV.
Azithromycin. When co-administered with fluconazole at a single dose of 800 mg with azithromycin at a single dose of 1200 mg expressed pharmacokinetic interaction between both drugs has not been established.
Benzodiazepines (short acting). After ingestion of midazolam, fluconazole significantly increases the concentration of midazolam and psychomotor effects, and this effect is more pronounced after fluconazole ingestion than when administered intravenously. If concomitant benzodiazepine therapy is required, patients receiving fluconazole should be monitored for the appropriate dose reduction of benzodiazepine.
Cisapride. With the concomitant use of fluconazole and cisapride, adverse reactions from the heart are possible, including: fluttering / fluttering of the ventricles (torsade de pointРs). The use of fluconazole at a dose of 200 mg once daily and cisapride at a dose of 20 mg 4 times a day leads to a marked increase in plasma concentrations of cisapride and an increase in the QT interval on the ECG. Co-administration of cisapride and fluconazole is contraindicated.
Cyclosporine. In patients with transplanted kidney, the use of fluconazole at a dose of 200 mg / day leads to a slow increase in the concentration of cyclosporine. However, with repeated administration of fluconazole at a dose of 100 mg / day, no change in the concentration of cyclosporine in bone marrow recipients was observed. With the use of fluconazole and cyclosporine, it is recommended to monitor the concentration of cyclosporine in the blood.
Hydrochlorothiazide. Repeated administration of hydrochlorothiazide with fluconazole leads to an increase in plasma fluconazole concentration by 40%. The effect of this degree of severity does not require changing the dosage regimen of fluconazole in patients receiving diuretics at the same time, howeverto consider.
Oral contraceptives. Concomitant use of combined oral contraceptive with fluconazole at a dose of 50 mg has no significant effect on the level of hormones, while the daily intake of 200 mg of fluconazole AUC of ethinylestradiol and levonorgestrel increase by 40 and 24%, respectively, and when receiving 300 mg of fluconazole The AUC of ethinyl estradiol and norethindrone increased by 24 and 13%, respectively. Thus, repeated use of fluconazole at these doses is unlikely to have an effect on the effectiveness of combination oral contraceptives.
Phenytoin. Concomitant administration of fluconazole and phenytoin may be accompanied by a clinically significant increase in phenytoin concentration. If both drugs are to be used concomitantly, phenytoin concentration should be monitored and dose adjusted accordingly to ensure serum therapeutic concentration.
Rifabutin. Concomitant use of fluconazole and rifabutin may increase serum concentrations of the latter. When fluconazole and rifabutin are used concomitantly, cases of uveitis have been reported. Patients receiving rifabutin and fluconazole should be closely monitored.
Rifampicin. Concomitant administration of fluconazole and rifampicin results in a 25% reduction in AUC and a fluconazole duration of T1 / 2 by 20%. Patients taking rifampicin at the same time should consider the feasibility of increasing the dose of fluconazole.
Sulfonylureas. Fluconazole, co-administered, leads to an increase in T1 / 2 oral preparations of sulfonylurea (chlorpropamide, glibenclamide, glipizide and tolbutamide). Patients with diabetes can be prescribed the combined use of fluconazole and oral preparations of sulfonylurea, but the possibility of developing hypoglycemia should be considered.
Tacrolimus. Concomitant use of fluconazole and tacrolimus leads to an increase in serum concentrations of the latter. Cases of nephrotoxicity are described. Patients receiving both tacrolimus and fluconazole should be closely monitored.
Terfenadine. With the use of azole antifungal agents and terfenadine, serious arrhythmias may occur as a result of increasing the QT interval. No increase in QT interval was observed with fluconazole 200 mg / day, however, the use of fluconazole at doses of 400 mg / day and above causes a significant increase in the plasma concentrations of terfenadine. Concomitant administration of fluconazole at doses of 400 mg / day or more with terfenadine is contraindicated (see Contraindications section). Fluconazole treatment at doses less than 400 mg / day in combination with terfenadine should be closely monitored.
Theophylline. When co-administered with fluconazole at a dose of 200 mg for 14 days, the average plasma clearance rate of theophylline is reduced by 18%. When fluconazole is given to patients receiving theophylline at high doses or to patients at increased risk of theophylline toxicity, the symptoms of theophylline overdose should be monitored and, if necessary, adjusted.
Zidovudine. When co-administered with fluconazole, there is an increase in concentrations of zidovudine, which is probably due to a decrease in the metabolism of the latter to its major metabolite. A significant increase in zidovudine AUC (20%) was found before and after treatment with fluconazole at 200 mg / d for 15 days in patients with AIDS and ARC (AIDS-related complex).
When administered to HIV-infected patients, zidovudine at a dose of 200 mg every 8 h for 7 days in combination with or without fluconazole at a dose of 400 mg / day showed a significant increase in zidovudine AUC (74%) between the two regimens. when co-administered with fluconazole. Patients receiving this combination should be observed to identify side effects of zidovudine.
Concomitant use of fluconazole with astemizole or other drugs metabolised by the cytochrome P450 system may be accompanied by increased serum concentrations of these agents. Caution should be exercised when fluconazole is administered concomitantly in the absence of reliable information. Patients should be carefully observed.
Studies on the interaction of oral forms of fluconazole with its concomitant administration with food, cimetidine, antacids, as well as after total body irradiation to prepare for bone marrow transplantation have shown that these factors do not have a clinically relevant effect on the absorption of fluconazole.
These interactions have been established with repeated use of fluconazole to interact with drugs as a result of single administration of fluconazole.
Doctors should note that interaction with other drugs has not been specifically studied, but it is possible.
overdose
Symptoms: fluconazole overdose has been reported, and in one case, a 42-year-old HIV-infected patient had hallucinations and paranoid behavior after taking 8200 mg of the drug. The patient was hospitalized and his condition normalized within 48 hours.
Treatment: symptomatic treatment (including supportive measures and gastric lavage).
Fluconazole is excreted mainly in the urine, so forced diuresis can probably accelerate the excretion of the drug. A 3-hour hemodialysis session reduces plasma fluconazole levels by about 50%.
Storage conditions
The drug should be stored at a temperature not exceeding 30 ° C, out of the reach of children.
Expiration
3 years.
Use the finished suspension for 14 days.
Do not use after the expiry date stated on the packaging.
Deystvuyuschee substances
Fluconazole
Cond Ovia pharmacy vacation
Prescription
Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. (Fluconazole) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Diflucan powder d / pr.suspension d / ingestion 50 mg / 5 ml 35 ml bottle 1 pc. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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