Dimexide gel 25% 30.0 (Dimethylsulfoxide)

Dosage form sdlkl41 .

Pharmacological action

Dimexide is an anti-inflammatory agent with local analgesic and anti-inflammatory effects. It has a moderate antiseptic and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. In addition, dimethyl sulfoxide helps normalize fibrin formation processes, increases microcirculation in tissues, inhibits red blood cell aggregation, increases phagocyte activity, suppresses neutrophil chemotaxis and reduces the content of circulating immune complexes.

Penetrates through the skin, mucous membranes, the cell wall of bacteria (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs. The drug is low toxic.

Pharmacokinetics

When the drug is applied, dimethyl sulfoxide is detected in the blood serum after 8–15 minutes, and the maximum content is observed after 2–8 hours. As a rule, after 30–36 hours, dimethyl sulfoxide in the blood serum is no longer detected. Dimethyl sulfoxide does not cumulate. With topical use of the drug, dimethyl sulfoxide penetrates the articular cavity, binds to proteins in the blood and tissues.

It is excreted from the body through the kidneys unchanged and excreted in the form of oxidized products - dimethyl sulfone and dimethyl sulfate as well as a reduced product (dimethyl sulfide) with exhaled air.

Indications

For the relief of pain during the complex treatment of the following diseases and conditions: rheumatoid arthritis

Ankylosing spondylitis

deforming osteoarthrosis

arthropathy

sciatica

trigeminal neuralgia

treatment of bruises

ligament damage

traumatic infiltrates

erythema nodosum.

Contraindications

hypersensitivity to Dimexidum or other components of the

preparation severe liver and kidney damage

angina pectoris

myocardial infarction

severe atherosclerosis

early childhood,



With caution: due to the fact that Dimexide can enhance not only the activity, but also the toxicity of certain drugs, caution should be exercised when it is prescribed simultaneously with other drugs.

Special instructions

Given the possibility of individual intolerance to the drug, it is recommended to conduct a drug test for tolerance to it. For this, the gel is applied in a thin layer on the skin of the elbow. The appearance of sharp redness and itching indicates an increased sensitivity to Dimexidum.

If allergic reactions occur during treatment with the drug, the drug is discontinued, H1-histamine receptor blockers are prescribed.

Composition of

Active ingredient: dimexide (dimethyl sulfoxide) 25 g

Excipients: methyl parahydroxybenzoate (nipagin) sodium nitroxymethyl nitroxymethyl nitroxymethyl nitroxymethyl nitroxymethyl nitroxymethyl nitroxymethyl nitroxybenzoic nitroxymethoxymethoxymethylmethoxymethylamine 2 g purified water - up to 100 g.

Dosage and Administration

Externally. For adults and children over 12 years of age, the drug is applied in a thin layer to the affected area 1-2 times a day. The duration of treatment is 10-14 days. Repeated courses can be conducted in no less than 10 days.

Side effects

In the process of using the drug, contact dermatitis, garlic smell of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, slight burning can be observed. Some patients have a poor perception of the smell of the drug (nausea, retching), in rare cases bronchospasm is possible. If any of the side effects indicated in the instructions have worsened or any other side effects not listed in the instructions have appeared, it is necessary to inform the doctor about this.

Drug interaction

Enhances the penetration through the skin of drugs (NSAIDs, antibiotics, etc.), which leads to an increase in their activity, and in some combinations, to toxicity.

Overdose

Symptoms: increased dose-related side effects.

Treatment: in these cases, the drug should be canceled, wash the damaged area, remove the drug.

Storage Conditions

At a temperature not exceeding 25 ° C.

shelf life

2 years

Terms and conditions

without prescription

Dosage form

gel for external use

Possible product names

Dimexid 25% 30.0 gel

DIMEXID 25% 30.0 GEL



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