Dolobene gel 45 g (Heparin Sodium, Dexpanthenol, dimethyl sulfoxide)

Release form

Gel for external use.

Pharmacological action

DMSO has anti-inflammatory, decongestant and local analgesic effects.

Anti-inflammatory activity is associated with some pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on tissues.

DMSO has a local analgesic effect by reducing the rate of nociceptive (pain) impulses in peripheral neurons. Decongestant action is provided by inactivation of hydroxyl radicals and an improvement in the subcutaneous metabolic reaction at the site of application of the drug. To a certain extent, the hygroscopic properties of DMSO are also responsible for its decongestant effect. DMSO (from 50% or more) penetrates through biological membranes, including through the skin, contributing to a better and deeper penetration into the tissues of other drugs used simultaneously with it.

heparin.

Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. Heparin exhibits a dose-dependent antithrombotic effect, enhancing the inhibitory activity of antithrombin III on the activation of prothrombin and thrombin. The penetration of heparin through healthy skin is dose dependent and is confirmed for dosage starting at 300 IU / g.

Dexpanthenol.

When applied topically, dexpanthenol is transformed in the skin into pantothenic acid (vitamin B group). The efficacy of dexpanthenol is comparable to that of pantothenic acid. Pantothenic acid as a component of coenzyme A is involved in various catabolic and anabolic processes in tissues, due to the improvement of granulation and epithelization processes, it contributes to the regeneration of damaged skin areas.

Indications

Edema, hematomas and inflammations of soft tissues, muscles, tendons, tendon sheaths,

closed injuries, bruises,

joint injuries with sprains and tendons,

epicondylitis of the shoulder (tendon, tenderness, tennis), elbow tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous membrane of the joint),

periarthritis of the shoulder joint,

acute neuralgia.

Contraindications

Hypersensitivity to one of the gel components (active / excipients),

bronchial asthma,

severe dysfunctions of the liver, kidneys,

severe disorders of the cardiovascular system,

pregnancy and lactation, up to 5 years,



open wounds at the site of application.

Special instructions

The place of application of the gel should be free of other medicines, cosmetics or any chemicals. Dolobene should not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or on damaged areas of the skin (due to radiation, severe sunburn, postoperative scars).

During treatment with the drug, photosensitivity of the skin may increase, therefore, during its use, intensive sun baths and visits to the solarium should be limited. In case of skin reactions, treatment should be discontinued. Due to the high absorption of dimethyl sulfoxide, do not use Dolobene in combination with other ointments and gels.

Composition of

100 g of gel contain:

Active substances:

Heparin sodium 50,000 IU

Dexpanthenol 2,500 g

Dimethyl sulfoxide 90% 16,660 g (in terms of dry matter) (15,000 g)

Ac , trometamol 0.200 - 0.300 g, macrogol glycerylhydroxystearate (Cremophor CO 455) 1,000 g, isopropanol 35,000 g, rosemary oil 0.200 g, pine mountain oil 0.250 g, citronella oil 0.050 g, purified water 42.023 - 42.913 g

Dosage and administration

Dolobene should be applied superficially to the skin over the affected area of ​​the skin 2-4 times a day.

When using the gel under the dressing, apply the gel and wait a few minutes for it to be absorbed by the skin and the isopropanol evaporated. An hermetic dressing can then be applied.

Dolobene can be used for iontophoresis. The drug is applied under the cathode. Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel complement the therapeutic effect of ultrasonic waves. The duration of treatment depends on the severity of symptoms and the severity of the disease.

Side effects

Local skin reactions (redness, itching, burning sensation at the site of application of the gel) are possible, which usually disappear during further treatment. Due to the content of DMSO or other components of the drug, a skin allergic reaction is sometimes possible.

In rare cases, during the use of the drug, some patients may smell garlic from the mouth. The smell is caused by dimethyl sulfide, a product of dimethyl sulfoxide metabolism. Perhaps a change in taste, disappearing a few minutes after applying the gel.

In isolated cases, allergic reactions of the immediate type (urticaria, Quincke's edema) may occur. It is extremely rare when applying the drug to large areas of the body that nausea, diarrhea, shortness of breath, headache, or chills can occur.

Drug Interactions

Applying another drug at the same time as Dolobene may increase their permeability through the skin. With the simultaneous use of the drug Dolobene and the non-steroidal anti-inflammatory drug sulindac, the development of peripheral neuropathy is possible.

Overdose

There is no evidence of an overdose of the drug.

Storage conditions

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children!

The Expiration of

is 3 years.

Dispensing conditions from the

pharmacies Over the counter

Form of Treatment

claim the gel dlya naruzhnogo primeneniya



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