Duphalac syrup 667 mg / ml 500 ml (lactulose)

Release form

Syrup.

Packing

Bottle 500 ml.

Pharmacological action

Has a hyperosmotic laxative effect, stimulates intestinal motility, improves the absorption of phosphates and Ca2 + salts, promotes the excretion of ammonium ions.

Lactulose is broken down by the intestinal flora of the colon into low molecular weight organic acids, which lead to a decrease in pH, and, due to an increase in osmotic pressure, increase the volume of intestinal contents. These effects stimulate intestinal motility and have an effect on stool consistency. Constipation disappears and the physiological rhythm of colon emptying is restored.

With hepatic encephalopathy and hepatic (pre) coma, the effect is attributed to the suppression of proteolytic bacteria by increasing the number of acidophilic bacteria (e.g. lactobacilli), the conversion of ammonia to ionic form by acidifying the contents of the colon to empty the intestines due to lower pH in the colon and osmotic effect and also a decrease in nitrogen content toxic substances by stimulating bacteria utilizing ammonia for bacterial protein synthesis.

Inhibits the growth of salmonella in the intestine, reduces the period of bacterial excretion.

Pharmacokinetics

Absorption is low without absorption, it reaches the large intestine, where it is split by the intestinal flora. It is completely metabolized at doses up to 45–70 ml at a higher dosage - partially excreted unchanged.

Indications

Constipation: regulation of the physiological rhythm of colon emptying

stool softening for medical purposes (for hemorrhoids, conditions after surgery on the colon and anus)

hepatic encephalopathy in adults: treatment and prevention of hepatic coma or.

Contraindications

Galactosemia

intestinal obstruction

perforation or risk of perforation of the gastrointestinal tract

intolerance to galactose or fructose, lactase deficiency or glucose-galactose malabsorption

component of any drug.

Caution: the drug should be prescribed for undiagnosed rectal bleeding with a colostomy, ileostomy.

Use during pregnancy and lactation

No effect on the fetus or infant is anticipated. the systemic effect of lactulose on a pregnant or lactating woman is negligible.

DufalacВ® can be prescribed during pregnancy and during breastfeeding.

No effect on reproductive function is expected, as the systemic effect of lactulose is negligible.

Composition

100 ml contain:

Active ingredient: lactulose 66.7 g

Excipients: purified water - up to 100 ml.

Side effects

In the early days of lactulose, flatulence may occur. As a rule, it disappears after a few days.

In the case of the use of high doses for a long time in the treatment of hepatic encephalopathy, the patient may develop disturbances in the water-electrolyte balance due to diarrhea.

From the digestive system: very often ( 1/10) - diarrhea often ( 1/100, <1/10) - flatulence, abdominal pain, nausea, vomiting.

Other: infrequently ( 1/1000, <1/100) - disturbances in the water-electrolyte balance due to diarrhea.

When used in children, a similar safety profile is expected compared to that in adults.

Overdose

Symptoms: Abdominal pain and diarrhea may occur with very high doses.

Treatment: discontinuation of the drug or dose reduction. In the event of a large loss of fluid due to diarrhea or vomiting, correction of water-electrolyte balance disorders may be required.

Storage conditions

Keep out of the reach of children at a temperature not exceeding 25 ° C.

Expiration

3 years.

dosage form

medic Dosage form

oral solution



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