Ethoxidol chewable tablets 100 mg, 20 pcs. (etylmetylhydroksypyrydyna Malate Malate Malate)

Release form

Chewable tablets.

Packing

20 tablets.

Pharmacological action of

Ethoxidol is an inhibitor of free radical processes, has a membrane protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. Ethoxidol has anti-ischemic properties, improves blood flow in the ischemic zone, limits the area of ​​ischemic damage, detects a lipid-lowering effect, reduces the content of total cholesterol and low density lipoproteins. The drug increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with alcohol and antipsychotic drugs (antipsychotics)).

The drug improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. It stabilizes the membrane structures of blood cells (red blood cells and platelets) during hemolysis. The mechanism of action of the drug is due to its antioxidant, antihypoxant and membrane protective effect. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the ratio of lipid protein, reduces the viscosity of the membrane, increases its fluidity.

Modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport neurotransmitters and improve synaptic transmission.

Pharmacokinetics

After ingestion, it is rapidly and completely absorbed from the gastrointestinal tract at an average rate of 0.569 ± 0.086 h-1. On healthy volunteers, it was found that with the oral administration of Ethoxidol tablets at a dose of 100 mg, the maximum concentration (C max) in blood plasma is reached after 0.28 ± 0.08 hours and amounts to 487.0 ± 72.4 ng / ml followed by rapid excretion the drug, with a half-life (T ) = 1.46 ± 0.13 hours. Ethoxidol is rapidly distributed to organs and tissues of the body. It is determined in blood plasma for 7-10 hours. The drug is extensively metabolized in the liver with the formation of phosphate-3-hydroxypyridine, glucuronoconjugated products.

Indications

coronary heart disease (as part of complex therapy)

complex therapy for ischemic stroke

discirculatory encephalopathy

mild to moderate cognitive impairment

Contraindications

Hypersensitivity to the drug Ethoxidol or its components,

pregnancy,

lactation,

under the age of 18 years,

lactose intolerance,

malignant and / or malignant

Use during pregnancy and lactation

Ethoxidol is contraindicated during pregnancy and lactation, since there are no strictly controlled clinical trials of the safety of the drug during pregnancy and lactation.

Composition

1 chewable tablet contains:

active substance: ethylmethylhydroxypyridine malate (ethoxide) 100 mg,

excipients: acet ilglutamic acid (N-acetyl-L-glutamic acid) 68 mg, deanol (2-dimethylaminoethanol) 32 mg, glycine 20 mg, microcrystalline cellulose 260.1 mg, povidone (collidone 90F) 1.6 mg, lactose monohydrate (milk sugar ) 36 mgcolloidal (aerosil) 9.5 mg, magnesium stearate 6 mg, croscarmellose sodium (primellose) 12.8 mg, sodium cyclamate 18 mg, orange flavor (flavoring food “Orange”) 6 mg

Dosage and Administration

Tablets Ethoxidol is prescribed orally. Chewed tablets and washed down with water.

For complex therapy of coronary heart disease and ischemic stroke therapy, 100 mg (1 tablet) is prescribed 3 times a day, gradually increasing the dose until a therapeutic effect is obtained. The maximum single dose - 200 mg daily - 800 mg. The course - at least 2 months, repeated courses - on the recommendation of a doctor.

The duration of treatment and the choice of individual dose depends on the severity of the patient's condition and the effectiveness of the treatment.

In the complex treatment of mild and moderate cognitive impairment, the drug is prescribed without limiting the course of treatment for a duration of 100 mg 3-4 times a day.

Side effects of

In rare cases, allergic reactions, dyspeptic disorders, nausea and dry mouth, diarrhea that quickly disappear on their own or when the drug is withdrawn are possible. With prolonged use, flatulence, sleep disturbances (drowsiness or falling asleep) are possible.

Drug Interaction

Enhances the action of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), antiparkinsonian agents (levodopa). Reduces toxic effects of ethyl alcohol.

Overdose

Due to the low toxicity of the drug, an overdose is unlikely. In case of accidental overdose, symptoms of sleep disturbance may occur - drowsiness, insomnia.

Treatment is symptomatic.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

Expiration

3 years.

Deystvuyuschee substances

Эtylmetylhydroksypyrydyna Malate

Pharmacy terms

Prescription

dosage form

dosage form

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