Famotidine tablets 40 mg, 20 pcs. (Famotidine)

Description

20 mg film-coated tablets: round, biconvex film-coated tablets, pale pink with a grayish tint, with a white fracture. Film-coated tablets 40 mg: round, biconvex tablets, film-coated tablets, pale brown with a slightly pinkish tint, on a fracture of white color.

Release form

Film-coated tablets



packaging 20 pcs

Pharmacological action

Famotidine has an antiulcer effect. Blocker of H2-histamine receptors of the III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces pepsin activity. Strengthens the protective mechanisms of the gastric mucosa, promotes the healing of damage associated with the action of hydrochloric acid (including scarring of stress ulcers) and the cessation of gastrointestinal bleeding by increasing the formation of gastric mucus, its glycoproteins, stimulating the secretion of bicarbonate by the gastric mucosa, endogenous prostaglandin synthesis in it and speed regeneration. Does not significantly change the level of gastrin in plasma. Weakly inhibits the oxidase system of cytochrome P450 in the liver.

After oral administration, the action begins after 1 hour, reaches a maximum within 3 hours. The duration of the drug with a single dose depends on the dose and ranges from 12 to 24 hours.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract, maximum plasma concentration is achieved within 1-3.5 hours. Bioavailability - 40-45%, increases when taken with food and decreases with antacids. Communication with plasma proteins - 15-20%.

30-35% of famotidine is metabolized in the liver (with the formation of S-oxide). It penetrates into the cerebrospinal fluid, through the placental barrier, excreted in breast milk.

Elimination mainly occurs through the kidneys: 27-40% of the drug is excreted unchanged in the urine. The elimination half-life is 2.5-4 hours, in patients with creatinine clearance below 30 ml per minute, it increases to 10-12 hours. In patients with severe renal failure (creatinine clearance below 10 ml / min), the elimination half-life increases to 20 hours.

Indications

Peptic ulcer and duodenal ulcer (including the prevention of exacerbations)

symptomatic ulcers, erosive and reflux esophagitis

Zollinger-Ellison syndrome.



Contraindications Hypersensitivity, pregnancy, lactation.

Composition of

1 tablet contains:

Active ingredient: famotidine 40 mg

Excipients: corn starch, microcrystalline cellulose, silicon dioxide, talc, magnesium stearate, croscarmellose sodium

6000 g, shell mucilum composition: talc, dye iron oxide brown.

Dosage and administration

Inside, swallowing whole (without chewing), drinking plenty of water. With peptic ulcer of the stomach and duodenum in the acute phase, symptomatic ulcers, erosive gastroduodenitis - usually 20 mg 2 times a day or 40 mg once a day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

With dyspepsia associated with increased secretory function of the stomach, 20 mg 1-2 times a day.

In order to prevent recurrence of peptic ulcer disease - 20 mg once a day at bedtime.

For reflux esophagitis, 20–40 mg 2 times a day for 6–12 weeks.

With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours.

For the prevention of aspiration of gastric juice with general anesthesia, 40 mg in the evening and / or in the morning before surgery.

In case of renal failure (with Cl creatinine <30 ml / min or serum creatinine> 3 mg / 100 ml), the daily dose should be reduced to 20 mg.

Side effects

Rarely - headache, dizziness, fatigue, dry mouth, lack of appetite, diarrhea or constipation, skin rash.

Drug Interaction

Antacids impair absorption (a break of at least 1-2 hours between taking antacids and famotidine is recommended).

Storage conditions

Store at 15 to 25 ° C.

Shelf life

3 years.

Deystvuyushtee substance

Famotidine

dosage form

tablets

Possible product names

FAMOTIDIN 0.04 N20 TABLE P / O

FAMOTIDIN 0.04 N20 TABLE P / O / HEMOFARM /

Famotidine 40mg Tab. p / pl / rev X20 (R)

Famotidine 40mg Tab./Pot. X20

Famotidine 40mg No. 20



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