Fosfomycin Esparma powder for solution for oral administration 3 g sachet 1 pc. (fosfomycin)

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newyork1003581
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Pharmacological action

Broad-spectrum antibiotic. It has a bactericidal effect. It is a structural analogue of phosphoenol pyruvate and penetrates into the microbial cell. The drug irreversibly inhibits the enzyme N-acetyl-glucocamino-3-o-eulpiruvyl transferase, irreversibly blocks the condensation of uridine diphosphate-N-acetyl-glucosamine with phosphoenolpyruvate, inhibits the synthesis of UDP-N-acetylmuramic acid, thus inhibiting the initial stage of formation of peptidoglycan of the bacterial cell wall.

The cross-resistance of the drug with other antibacterial agents is unknown. In vitro, when combined with amoxicillin, cephalexin, pipemidine gold, a pronounced synergism of antimicrobial action is noted.

In vitro, gram-positive (Staphylococcus saprophytticus, nterococcus faecalis) and gram-negative (Escherichia coli, Klebsiella pneumoniea, Citrobacter spp., Enterobacter spp., Proteus mirabilis) susceptible to phosphomycin. In vitro fosfomycin trometamol reduces the adhesion of a number of bacteria to the urinary tract epithelium. Buy Fosfomycin Esparma powder for solution for oral administration 3 g sachet 1 pc. (fosfomycin) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmacological action

Broad-spectrum antibiotic. It has a bactericidal effect. It is a structural analogue of phosphoenol pyruvate and penetrates into the microbial cell. The drug irreversibly inhibits the enzyme N-acetyl-glucocamino-3-o-eulpiruvyl transferase, irreversibly blocks the condensation of uridine diphosphate-N-acetyl-glucosamine with phosphoenolpyruvate, inhibits the synthesis of UDP-N-acetylmuramic acid, thus inhibiting the initial stage of formation of peptidoglycan of the bacterial cell wall.

The cross-resistance of the drug with other antibacterial agents is unknown. In vitro, when combined with amoxicillin, cephalexin, pipemidine gold, a pronounced synergism of antimicrobial action is noted.

In vitro, gram-positive (Staphylococcus saprophytticus, nterococcus faecalis) and gram-negative (Escherichia coli, Klebsiella pneumoniea, Citrobacter spp., Enterobacter spp., Proteus mirabilis) susceptible to phosphomycin. In vitro fosfomycin trometamol reduces the adhesion of a number of bacteria to the urinary tract epithelium.

Indications

Bacterial urinary tract infections of various localization caused by microorganisms sensitive to fosfomycin: acute uncomplicated urinary tract infections asymptomatic bacteriuria prevention of urinary tract infections after surgery and transurethral diagnostic tests.

Contraindications

hypersensitivity to fosfomycin or other components of the

preparation severe renal failure (creatinine clearance <20 ml / min)

children under 12 years of age, since there is insufficient data on its use

sucrose / isomaltase deficiency

fructose intolerance

glucose-galactose malabsorption.

Recommended use for

Inside.

Fosfomycin Esparma is used once, on an empty stomach, 2-3 hours before or after meals, preferably before bedtime, after emptying the bladder: c: for tall and children over 12 years old in a daily dose of 3 g. The contents of one packet are dissolved in about 150- 200 ml of water and taken immediately after preparation.

The course of treatment is 1 day.

For the prevention of urinary tract infections during surgery, diagnostic procedures, the specified dose is taken 2 times - 3 hours before the intervention and 24 hours after it.

Fosfomycin Esparma should not be taken in patients weighing less than 50 kg and children under 12 years of age, since the dose cannot be divided or reduced.

Special instructions

The occurrence of acute and persistent diarrhea during or after antibiotic treatment can be a symptom of colitis caused by taking antibiotics. The most serious norm is pseudomembranous colitis. In case of pseudomembranous colitis, appropriate measures must be taken immediately. In this case, the use of drugs that slow down peristalsis is contraindicated.

The preparation contains sucrose. Patients with rare hereditary diseases, fructose intolerance, malabsorption of glucose-galactose, or sucrose-isomaltase deficiency should not take this drug.

One packet of Fosfomycin Esparma contains approximately 2.3 g of sucrose, which is equivalent to approximately 0, 19 bread units (XE).

The simultaneous intake of poverty slows down the absorption of granules, therefore, it is recommended to take the drug on an empty stomach, 2-3 hours before or after a meal.

Impact on the ability to drive transp. Wed and fur .:

Patients should be warned about the possibility of dizziness and, if dizziness occurs, should refrain from performing these activities.

Side effects

The frequency of development of side effects is in the following groups:

Very common: (> 1/10)

Frequent: (> 1 / 100- <1/10)

Me frequent: (> 1 / 1.000 - < 1/100)

Rare: (> 1 / 10.000- <1 / 1.000)

Very rare: (<1 / 10.000)

Unknown: (the incidence of side effects based on existing data is not determined).

From the side of the overbearing system:

Frequent: headache, dizziness, asthenia

Not frequent: numbness, goosebumps, paresthesia

Unknown: optic neuritis

From the cardiovascular system:

Rarely:

pressure from the respiratory system, chest and mediastinal organs:

Unknown: bronchial asthma

Immune system:

Unknown: pruritus, anaphylactic shock, hypersensitivity reactions (angioedema, skin rash, urticaria)

From the gastrointestinal tract: diarrhea, nausea, dyspepsia

Rare: vomiting

Unknown: pseudomembranous colitis, abdominal pain

From the side of the liver and biliary tract:

Not frequent: increased activity of hepatic transaminases

From the genitals and milk of the gland:

Not frequent: vulvovaginitis

From the blood and lymphatic system:

Not frequent: thrombocytosis, leukopenia

If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not listed in the instructions, inform your doctor.

Overdose

Overdose symptoms: vestibular syndrome, hearing impairment, metallic taste and general taste disturbances, diarrhea. No specific antidote has been identified.

Symptomatic treatment if necessary.

Storage conditions

At a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Expiration

3 years.

Do not use after the expiration date printed on the package.

Deystvuyuschee substances

fosfomycin

drugstore drugstore terms

drugstore prescription words from the drugstore

Prescription



Fosfomycin Esparma powder for solution for oral administration 3 g sachet 1 pc. (fosfomycin) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Fosfomycin Esparma powder for solution for oral administration 3 g sachet 1 pc. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.

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