Fungoterbin cream 1%, 15 g p1srof4 Fungoterbin Neo gel, 15 g (Terbinafine, Urea)

Release form

Gel.

Packaging

15 g.

Pharmacological action

Terbinafine - the active substance of Fungoterbine®, is allylamine and has a wide spectrum of antifungal action.

Active against dermatophytes such as Trichophyton (T. rubrum, T. mentagrophytes, T. tonsurans, T. verrucosum, T. violaceum), Microsporum canis, Epidermophyton floccosum. At low concentrations, it has a fungicidal effect against dermatophytes, molds (Aspergillus, Cladosporium, Scopulariopsis brevicaulis, etc.) and some dimorphic fungi. The effect on yeast fungi of the genus Candida and its mycelial forms can be fungicidal or fungistatic, depending on the type of fungus. Terbinafine is also active against Pityrosporum, the causative agent of the multicolored (pityriasis) depriving Pityriasis versicolor caused by Pityrosporum ovale.

Terbinafine disrupts the ergosterol biosynthesis in mushrooms in the early stages. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus. This enzyme does not belong to the cytochrome P450 system. Terbinafine does not affect the metabolism of hormones or other drugs.

Due to the presence of urea in the cream and spray, the drug has a moisturizing effect, promotes a deeper penetration of terbinafine into the skin and, thus, creates high concentrations in it.

For the spray in addition: the urea (urea), which is part of the spray, has a keratolytic (softening and causing rejection of the stratum corneum of the epidermis affected by a fungal infection). Urea promotes rapid recovery of the epidermis. Butylhydroxytoluene is an antioxidant that stimulates regeneration processes. When applied topically, it inhibits free radical reactions.

Indications

Treatment and prevention of fungal skin diseases: - fungal infections of the skin, incl. foot mycoses (foot fungus), inguinal epidermophytosis (tinea cruris), fungal lesions of smooth body skin (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum

are skin infections caused by yeast-like fungi of the genus Candida (e.g. Candida albicans)

are colorful lichen (Pityrosporum versicolor) caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Contraindications

hypersensitivity to terbinafine or any other component that is part of the drug Fungoterbin Neo.

Composition

1 g: - terbinafine hydrochloride mg 10 mg dibunol), carbomer (carbopol), trolamine (thermostable triethanolamine, 2,2I, 2II-nitriloethanol), propylene glycol - up to 1 g.

Dosage and Administration

Externally. Before use, it is necessary to clean and dry the affected areas. Fungoterbin® is applied 1 or 2 times a day to the affected areas of the skin and adjacent areas. The cream is applied in a thin layer and lightly rubbed. When applied to the area of ​​skin folds (inguinal, intergluteal, under the mammary glands), it is recommended to lay a gauze bandage / bandage.

Dermatomycosis of the trunk, large folds, legs: 1 time per day, treatment duration - 1 week.

Dermatomycosis of the feet: 1 time per day, duration of treatment - 1 week.

Candidiasis of the skin: 1-2 times a day, duration of treatment - 1-2 weeks

Multi-colored lichen: 1-2 times a day, duration of treatment - 1 week.

Side effects

In rare cases, redness, itching or burning sensation at the place of application of the cream was noted, however, these phenomena rarely led to the need to discontinue treatment. The above symptoms should be distinguished from allergic reactions (e.g. urticaria, generalized rash and / or redness, angioedema, repeated allergic reaction), which occur rarely, however, when they appear, stop treatment.

active substance

Terbinafine, Urea

Terms of delivery from

pharmacies Over-the-counter

dosage form

gel for external use

Nizhpharm, Russia



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