Gastal tablets for resorption of 30 pieces. (Hydrotaltsyt, magnesium hydroxide)

Latin name

Gastal

release form

tab suction cups

Packing

30 pcs

Indications

Dyspeptic symptoms such as discomfort or pain in the epigastrium, heartburn, sour belching after errors in diet, excessive consumption of ethanol, coffee, nicotine, etc.

dyspeptic symptoms, such as discomfort or pain in the epigastrium, heartburn, sour belching (and their prevention), resulting from the use of certain drugs (non-steroidal anti-inflammatory drugs, glucocorticosteroids, etc.)

conditions accompanied by increased acid formation: peptic ulcer gastritis, reflux esophagitis hernia of the esophageal opening of the diaphragm.

Contraindications

Hypersensitivity to aluminum salts, magnesium or other components of the drug severe renal failure Alzheimer's disease hypophosphatemia lactose intolerance, lactase deficiency or glucose-galactose malabsorption children under 6 years of age.

With caution

For chronic renal failure (CRF), pregnancy and breastfeeding, adults and children over 12 years old with body weight less than 50 kg, children from 6 to 12 years old, elderly age.

Use during pregnancy and lactation

GastalВ® is not excreted in breast milk. When used during pregnancy and during breastfeeding, it is necessary to assess the ratio of benefits for the mother and risk for the fetus and baby.

Composition of

1 tablet contains:

active ingredients:

aluminum hydroxide-magnesium carbonate gel 450.0 mg,

magnesium hydroxide 300.0 mg

excipients:

mannitol (E421) 120.00 mg, sorbitol (E420) 50.00 mg, lactose monohydrate 30.00 mg, corn starch 75.80 mg, sodium cyclamate 7.00 mg, sodium saccharin 0.20 mg, talc 28.00 mg, magnesium stearate 6.00 mg, peppermint flavor 3 , 00 mg.

Dosage and administration

Inside, gradually dissolving in the mouth.

Adults and children over 12 years old with a body weight of at least 50 kg

1-2 tablets 4-6 times a day, approximately 1 hour after eating and at bedtime, but not more than 8 tablets per day. Duration of admission is no more than 2 weeks.

Similar doses are recommended for treating heartburn regardless of food intake.

Adults and children over 12 years old with a body weight of less than 50 kg, children aged 6 to 12 years

The dose is half the recommended dose for adults and children over 12 years of age with a body weight of at least 50 kg. Duration of admission is no more than 2 weeks.

Patients with chronic renal failure

Dose adjustment not required. Duration of admission is no more than 2 weeks.

Side effects of

When using the drug in recommended doses, adverse reactions are rare (not less than 0.01%, but less than 0.1%): nausea, constipation, diarrhea, change in taste. In exceptional cases, allergic reactions are possible.

Drug Interaction

Gastal® preparation at the same time enhances the activity of levodopa and nalidoxin indirect anticoagulants, barbiturates.

Tetracyclines form insoluble chelate complexes by reacting with metal ions that are part of antacids as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous administration of these drugs is impossible. When combined, tetracycline should be taken at least 2 hours before the antacid is taken.

In the presence of the aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the plasma metoprolol concentration.

Concomitant use of high doses of antacids can reduce ranitidine absorption by 10-33%.

The use of antacids does not affect the bioavailability of amoxicillin, cephalexin, and a combination of amoxicillin and clavulanic acid, but may significantly reduce the absorption of doxycycline from the gastrointestinal tract.

Increasing the urine pH against antacid therapy can help to increase tubular reabsorption of essential (alkaline) drugs and reduce reabsorption of acidic compounds. Antacids can reduce and slow the absorption of salicylates, including acetylsalicylic acid, and, by increasing the urine pH, promote faster elimination of salicylates with urine from the body, with a concomitant decrease in their serum concentration by 30-70%.

The absorption of cardiac glycosides, including digoxin and digitoxin, is not significantly reduced when used with antacids.

M-cholin blockers, by slowing the motility of the stomach, increase the duration of the drug Gastal®.

In order to prevent the possible interaction of Gastal® with other drugs, it is recommended that it be administered 1 hour before or 1 hour after use.

Overdose

Symptoms of an acute overdose are not described.

With prolonged use of high doses of preparations containing aluminum and magnesium, the development of hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminiemia, encephalopathy, nephrocalculia, may develop. It is possible to develop more pronounced undesirable reactions from the gastrointestinal tract (gastrointestinal tract) (constipation, diarrhea), in patients with renal insufficiency - thirst, a decrease in blood pressure, and hyporeflexia.

Treatment: symptomatic therapy.

Storage conditions

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf suitability

3 Year

Deystvuyuschee substances

Hydrotaltsyt, magnesium hydroxide



pharmacy over-the-counter conditions

dosage form

dosage form

lozenges

Teva Pharmaceutical Enterprises Co., Ltd., Israel



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