GrippoFlu sachets with lemon flavor 13 g, 8 pcs. (enylephrine, Phenyramine, Ascorbic acid)

Release form

Powder for solution for oral administration.

Packing

8 sachets

Pharmacological action

Combined drug. Paracetamol is a non-narcotic analgesic that affects the centers of pain and thermoregulation. It has an analgesic and antipyretic effect. Reduces headaches and muscle aches, fever, softens sore throats.

Pheniramine - a blocker of H1-histamine receptors, an anti-allergic agent, reduces rhinorrhea and lacrimation, eliminates spastic phenomena.

Phenylephrine - an adrenergic agonist with moderate vasoconstrictor action, reduces nasal congestion and facilitates breathing through the nose.

Ascorbic acid - is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, increases the body's resistance to infections, reduces vascular permeability. Improves the tolerance of paracetamol and lengthens its effect.

Indications

Infectious-inflammatory diseases (SARS, influenza), accompanied by fever, chills and fever, headache, runny nose, stuffy nose, sneezing and muscle pain.

Contraindications

arterial hypertension

diabetes mellitus

angle-closure glaucoma

severe diseases of the liver, kidney, heart, thyroid gland, lungs (including bronchial asthma), urinary bladder

gastric ulcer with prostate adenoma

diseases of the blood system

deficiency of the enzyme glucose-6-phosphate dehydrogenase

pregnancy and lactation

for children under 12

hypersensitivity to individual components of the drug.

Precautions: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), prostatic hyperplasia.

Special instructions

Without the advice of a doctor, pregnant women and nursing mothers, as well as patients undergoing treatment with other drugs, in particular MAO inhibitors, should not use the drug.

The drug is not prescribed for children under the age of 12 years.

Effect on the ability to drive vehicles and control mechanisms

When taking the drug, it is not recommended to drive a car or other mechanisms, drink alcohol, drugs that depress the central nervous system (sleeping pills, tranquilizers, etc.).

Composition

1 sachet contains: paracetamol 0.325 g, phenylephrine hydrochloride 0.010 g pheniramine maleate 0.020 g, ascorbic acid 0.050 g

Excipients: sugar, citric acid, sodium citrate dihydrate, calcium phosphate 3-substituted diene, titanium dihydrogen, titanium diol, di yellow E-104, acid red 2C for pharmaceutical purposes.

Dosage and administration

Dissolve the contents of one packet in 1 cup of boiled hot water and use it hot. You can add sugar to taste. A repeated dose can be taken every 4 hours, but not more than 3 doses of the drug within 24 hours. The duration of admission as an antipyretic is not more than 3 days.

Side effects

Allergic reactions (skin rash, pruritus, urticaria, angioedema), nausea, epigastric pain, anemia, thrombocytopenia.

Increased irritability, dizziness, increased blood pressure, palpitations, impaired falling asleep.

Increased intraocular pressure, dry mouth, urinary retention.

With prolonged use in large doses, hepatotoxic and nephrotoxic effects are possible (renal colic, glucosuria, oyster nephritis, papillary necrosis), hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

Drug Interactions

Enhances the effects of monoamine oxidase inhibitors, sedatives, ethanol. Ethanol enhances the sedative effect of antihistamines.

antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention of dry mouth, constipation.

Glucocorticosteroids increase the risk of developing increased intraocular pressure.

Paracetamol reduces the effectiveness of uricosuric drugs and increases the effectiveness of indirect anticoagulants.

Tricyclic antidepressants enhance the sympathomimetic effect, the simultaneous administration of halothane increases the risk of ventricular arrhythmia.

Reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulatory activity of phenylephrine.

Overdose

Symptoms (caused by paracetamol): pale skin, decreased appetite, nausea, vomiting, hepatonecrosis. Toxic effect in adults is possible after taking more than 10-15 g of paracetamol, increased activity of "hepatic" transaminases, an increase in prothrombin time (12-48h after administration) a detailed clinical picture of liver damage manifests itself in 1-6 days. Rarely, liver failure develops rapidly and may be complicated by renal failure (tubular necrosis).

Treatment: administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 h after overdose and N-acetylcysteine ​​after 12 hours. The need for additional therapeutic measures is determined by the concentration of paracetamol in the blood, as well as by the time elapsed after its administration.

Storage Conditions

In a dry, dark place at a temperature not exceeding + 30 ° C.

shelf life

2 years

Active ingredient

Paracetamol, Phenylephrine, Phenyramine, Ascorb Novaya Chisloth

Conditions of release from drugstores

Without prescription

Marbiopharm, Russia



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