Heparin-Akrikhin 1000 gel for external use 1 thousand IU / g of 50 g (sodium heparin)

Release form

Gel for external use.

Pharmacological action of

ATX code: C05BA03

Pharmacological properties of

Pharmacodynamics

Direct anticoagulant, has anti-inflammatory, antiproliferative, decongestant and analgesic effects. Reduces platelet aggregation, binds antithrombin III, preventing the passage of prothrombin to thrombin. Inhibits the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood.

Improves microcirculation and activates tissue metabolism, due to this it accelerates the resorption of hematomas and blood clots, ultimately restores patency of the veins, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect.

Pharmacokinetics

A small amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of the active substance in the blood is observed 8 hours after application. Excretion of heparin mainly occurs through the kidneys, the elimination half-life is 12 hours.

Indications

Thrombophlebitis of superficial veins localized infiltrates and swelling of soft tissues injuries of tendons and joints, bruises of soft tissues and joints.

Contraindications

Hypersensitivity to any of the components of the drug, ulcerative necrotic changes in the skin at the site of the alleged application of the gel, traumatic violation of the integrity of the skin, decreased blood clotting, thrombocytopenia.

Use during pregnancy and lactation

The drug is not contraindicated for use during pregnancy and lactation.

Special instructions

Not recommended for use in bleeding, as well as in open wounds, mucous membranes and in the presence of local purulent processes.

Use with extreme caution in cases of increased vascular permeability.

The use of the gel is not recommended for deep venous thrombosis.

Composition

100 g of gel contain:

active substance: dry heparin of sodium in terms of dry matter - 0.83 g (100,000 ME)

excipients:

methyl parahydroxybenzoate - 0.15 g,

carbomer 940 - 1.25 g,

trometamol - 0.85 g,

ethanol 96 % (rectified ethyl alcohol) - 24 g,

lavender oil - 0.02 g,

orange flower oil (neroly oil) - 0.01 g,

purified water - up to 100 g

Dosage and Administration

Externally. The gel is applied in a thin layer on the affected area at the rate of 3-5 cm of gel on a skin area with a diameter of 3-5 cm and gently rubbed into the skin.

Apply 1-3 times a day daily until the onset of inflammation, an average of 3 to 7 days. The timing of treatment is determined by the doctor.

Side effects

Skin allergic reactions, hyperemia of the skin.

Drug Interactions

It is not recommended to mix with other products for external use.

Do not topically be prescribed simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.

Co-administration of the gel with oral anticoagulants may cause prolonged prothrombin time.

Overdose

An overdose is unlikely due to the low absorption of the gel components. Manifested by bleeding. Removed protamine sulfate (chemical antagonist).

Storage Conditions

At 15 to 25 ° C.

Keep out of the reach and sight of children.

Expiration

2 years.

Active ingredient

Heparin sodium

Terms leave through pharmacies

without prescription

lekarstvennaja form

Gel naruzhnej Application

Indications

Indications

Inflammation of tendons, Dislocations and astyazheniya, bruises, contusions, thrombophlebitis, varicose veins, swelling after injuries and operations



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