Hydrea capsules 500 mg, 20 pcs. (Hydroksykarbamyd)

Release form

Capsules.



packaging 20 pcs

Pharmacological action

Pharmacodynamics

Antitumor agent. The proposed mechanism of action is inhibition of DNA synthesis. It does not affect the synthesis of protein and RNA.

Pharmacokinetics

After oral administration, it is well absorbed from the gastrointestinal tract. Penetrates through the BBB. Metabolized in the liver. It is excreted mainly by the kidneys (80%). T1 / 2 - 3-4 hours

Indications

Chronic myelogenous leukemia

melanoma

ovarian cancer cervical cancer

choriocarcinoma of the uterus

tumor of the head and neck

brain tumor

erythremia.

Contraindications

Leukopenia less than 2500 / μl

thrombocytopenia less than 100,000 / μl

severe anemia

pregnancy

hypersensitivity to hydroxycarbamide.

Use during pregnancy and lactation

Hydroxycarbamide is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.

Women of childbearing age receiving hydroxycarbamide therapy should use reliable methods of contraception.

In experimental studies, the teratogenic and embryotoxic effects of hydroxycarbamide were established.

Composition

1 capsule contains:

Active substances: hydroxycarbamide 500 mg.

Dosage and administration

Installed individually, depending on the indications and stage of the disease, the state of the hematopoietic system, anti-tumor therapy regimen.

Side effects

From the hematopoietic system: leukopenia, thrombocytopenia, anemia.

From the digestive system: stomatitis, anorexia, nausea, vomiting, diarrhea, constipation rarely - impaired liver function.

From the side of the central nervous system: feeling tired, headache, drowsiness, dizziness, hallucinations, cramps.

From the respiratory system: in some cases - diffuse pulmonary infiltrates, accompanied by fever and shortness of breath.

From the urinary system: difficulty urinating rarely - impaired renal function.

Dermatological reactions: alopecia, maculopapular rash, erythema.

Other: fever, chills.

Drug Interaction

Increased myelodepression in the case of prior cytotoxic therapy.

Overdose

Treatment symptomatic, because no specific antidote is dialyzed.

Storage conditions

Store in a dark place at a temperature of 15–25 ° C.

Keep out of the reach of children.

Expiration

5 years.

Deystvuyuschee substances

Hydroksykarbamyd

Capsule Dosage Form A dosage form



capsules

Bristol-Myers Squibb, US



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