Ibuprofen tablets 200 mg, 50 pcs. (ibuprofen)

packaging 50 pcs

Pharmacological action

It has anti-inflammatory, analgesic and moderate antipyretic activity.

Ibuprofen is a non-steroidal drug with anti-inflammatory activity, painkillers (analgesic) and antipyretic properties.

According to the anti-inflammatory and antipyretic effect of ibuprofen, it is similar to acetyl-salicylic acid, but surpasses it in analgesic activity. The drug is well absorbed from the gastrointestinal tract,

Indications

Ibuprofen is used as an anesthetic and anti-inflammatory agent in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still's disease), ankylosing spondylitis, osteoarthritis and other non-rheumatoid (arthropathic) seronegative. Ibuprofen is indicated: for the treatment of non-rheumatic inflammatory processes of periarticular tissues, such as a “frozen” shoulder (inflammation of the joint membrane), bursitis, tendonitis, tenosynovitis and lower back pain. Ibuprofen can also be used to relieve pain in soft tissue damage, such as sprains. Ibuprofen is also indicated as an anesthetic for relieving mild to moderate pain in conditions such as dysmenorrhea, toothache or postoperative pain, for symptomatic relief of headaches, including migraines.

Contraindications

Ibuprofen is contraindicated in patients with hypersensitivity to the active or excipients of the drug.

Ibuprofen should not be used in patients who have previously experienced hypersensitivity reactions (eg, asthma, urticaria, Quincke's edema or rhinitis) after taking ibuprofen, aspirin or other NSAIDs.

Ibuprofen is also contraindicated in patients with a history of gastrointestinal bleeding or perforation associated with previous ibuprofen therapy. Ibuprofen should not be used in patients with recurrent peptic ulcer or gastrointestinal bleeding (two or more episodes of proven ulceration or bleeding). Ibuprofen should not be prescribed to patients with conditions accompanied by an increased tendency to bleeding.

Ibuprofen is contraindicated in patients with severe heart failure, hepatic and renal failure.

Ibuprofen is contraindicated during the last trimester of pregnancy.

Use during pregnancy and lactation

Ibuprofen should not be used in the third trimester of pregnancy. The use in the I and II trimesters of pregnancy is justified only in cases where the expected benefit to the mother outweighs the possible risk to the fetus.

Ibuprofen in small amounts is excreted in breast milk. Application during lactation for pain and fever is possible. If you need long-term use or use in high doses (more than 800 mg / day), you should decide on the termination of breastfeeding.

Composition

Each tablet contains:

active ingredient: ibuprofen - 200 mg

excipients: potato starch, magnesium stearate, calcium stearate, povidone, opadrai ?? (contains polyvinyl alcohol, partially hydrolyzed, talc, macrogol 3350, lecithin, titanium dioxide (E 171)).

Dosage and Administration

For oral administration. It is advisable to use during or after meals with water. Tablets should be swallowed whole, do not chew, do not break, do not crush in order to avoid discomfort and irritation of the throat.

Side effects can be minimized by applying the lowest effective dose in a short time.

Adults: The recommended dosage of ibuprofen is 1200-1800 mg per day, in divided doses. Some patients may take 600-1200 mg of ibuprofen per day. In severe or acute conditions, you can increase the dosage, provided that the total daily dose does not exceed 2400 mg, in several doses.

Children: The daily dose of ibuprofen is 20 mg / kg body weight in several doses. In juvenile rheumatoid arthritis, the dose can be increased to 40 mg / kg body weight in several doses.

Not recommended for children weighing less than 7 kg.

Elderly: Elderly people are at increased risk of side effects. If it is necessary to use non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen should be used in a low effective dose for a short time. The patient should regularly check for the absence of gastrointestinal bleeding while taking NSAIDs. In the presence of renal or liver failure, the dosage should be determined individually.

Side effects of

From the gastrointestinal tract: nausea, vomiting, abdominal pain, heartburn, anorexia, diarrhea, flatulence, NSAID gastropathy.

From the nervous system: headache, dizziness, hearing loss, tinnitus, insomnia, agitation, drowsiness, depression.

From the CCC side: heart failure, tachycardia, increased blood pressure. From the urinary system: edematous syndrome, impaired renal function.

Allergic reactions: skin rash, itching, urticaria, Quincke's edema, rarely - aseptic meningitis (more often in patients with autoimmune diseases)), bronchospasm.

From the side of hematopoietic organs: anemia, thrombocytopenia, agranulocytosis, leukopenia.

Drug Interaction

Ibuprofen may increase plasma concentrations of methotrexate, lithium and digoxin when co-administered with these drugs. Ibuprofen, like other non-steroidal anti-inflammatory drugs (NSAIDs), can reduce the effect of diuretics, calcium channel blockers and ACE inhibitors, which is associated with impaired renal prostaglandin synthesis. Concomitant use with potassium-sparing diuretics may lead to increased potassium levels in the blood (monitoring of plasma potassium levels should be monitored if necessary). There are reports of increased risk of bleeding in the case of the combined use of ibuprofen and anticoagulants, fibrinolytic drugs. When used together with antidepressants, barbiturates, zixorin, rifampicin, phenylbutazone, phenytoin, the risk of severe intoxication is increased by increasing the production of hydroxylated active metabolites of ibuprofen. Ibuprofen enhances the sugar-lowering effectiveness of oral hypoglycemic agents, which requires a dose adjustment of these drugs against the background of ibuprofen. Glucocorticosteroids and mineralocorticosteroid hormones, colchicine increase the anti-inflammatory effect of ibuprofen and increase the risk of gastrointestinal tract damage. When combined with cefamandol, cefoperazone, cefotethan, valproic acid and plicamycin increase the risk of hypoprothrombin. Cyclosporine and gold preparations enhance the nephrotoxic effect of ibuprofen. Ibuprofen enhances the unwanted effect of estrogens when used together. Ibuprofen weakens the effectiveness of the uricosuric effect of anti-gout agents. Colestyramine slows the absorption of ibuprofen. Caffeine enhances the analgesic effect of ibuprofen. Ibuprofen increases ethanol toxicity. When combined, acetylsalicylic acid attenuates the effect of ibuprofen and increases its toxicity, this is due to the displacement of ibuprofen from its association with proteins and its metabolism to the formation of toxic hydroxylated metabolites. Cherry and currant juice, sugar syrup increase the absorption rate of ibuprofen

overdose

Symptoms: The typical clinical picture does not develop with an overdose of ibuprofen. The appearance of abdominal pain, nausea, vomiting, dizziness, drowsiness, drowsiness, depression, headache, hypotension, convulsions, heart rhythm disorders, acute renal failure, respiratory depression. Treatment: Assistance measures include drug withdrawal, supportive and symptomatic therapy aimed at eliminating disorders, correction of acid-base status. It is possible to carry out forced diuresis with the simultaneous appointment of alkaline drink, to reduce the reabsorption of ibuprofen. There is no specific antidote. Gastric lavage is effective only within 1 hour after administration of the drug.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

Expiration

3 years.

Active substance thy

ibuprofen

dosage form

Dosage form

tablets

Borisov factory, Belarus



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