Kapoten tablets 25 mg, 40 pcs. (Captopril)

Release form

Tablets.

Packing

40 pcs.

Pharmacological action

Competitive ACE inhibitor, an enzyme that promotes the conversion of angiotensin I to angiotensin II.

Kapoten has an antihypertensive effect, reduces OPSS (afterload), preload and resistance in the pulmonary vessels increases cardiac output and exercise tolerance.

With prolonged use, it reduces the severity of left ventricular myocardial hypertrophy, prevents the progression of heart failure and slows down the development of left ventricular dilatation.

Indications

- arterial hypertension (as monotherapy and in combination with other antihypertensive drugs, for example, with thiazide diuretics)

- chronic heart failure (as part of combination therapy)

- IHD (impaired left ventricular myocardial function in patients with post-infarction in a stable clinical condition)

- diabetic nephropathy (microalbuminuria> 30 mg / day) with insulin-dependent diabetes mellitus.

Contraindications

- Quincke's edema (hereditary or associated with the use of ACE inhibitors in history)

- severe impaired renal function

- severe hepatic impairment

- hyperkalemia

- bilateral stenosis of the arterial arterial artery or after

kidney transplantation - stenosis of the aortic orifice and similar obstructive changes, obstructing the outflow of blood from the left ventricle

- pregnancy

- lactation (breastfeeding)

- hypersensitivity to the drug and other ACE inhibitors.

Special instructions

Caoten should be prescribed with caution in collagenoses because of the increased risk of neutropenia and agranulocytosis.

When prescribing the drug to patients with severe impaired water-electrolyte balance, this condition should be corrected. During treatment with Kapoten, it is not recommended to take potassium-sparing diuretics or potassium preparations, especially for patients with severe renal impairment.

Angioedema of the extremities, face, lips, mucous membranes, tongue, pharynx or larynx is observed in patients with the use of ACE inhibitors, including captopril. If swelling is limited to the face and lips, this condition usually disappears after discontinuation of the drug. Antihistamines may be used to alleviate clinical symptoms. Patients should be monitored by a doctor until symptoms disappear. If the swelling covers the tongue, pharynx or larynx with a threat of airway obstruction, s / c 0.5 ml of 0.1% adrenaline solution should be administered.

During treatment with Kapoten, a low sodium diet is indicated.

Kapoten may cause a false-positive reaction when analyzing urine for acetone.

Use in pediatrics

Safety and efficacy of the drug in children have not been studied.

Composition

1 tablet contains captopril 25 mg.

Dosage and administration

Doses of Kapoten should be selected by the doctor. Inside, an hour before meals, 25-50 mg 2-3 times a day (but not more than 450 mg per day), for children, the initial dose of 0.15-0.3 mg / kg (but not more than 6 mg / kg day).

Side effects of

From the cardiovascular system: orthostatic hypotension, tachycardia, peripheral edema.

From the respiratory system: dry cough, bronchospasm, pulmonary edema.

Allergic reactions: angioedema of the extremities, face, lips, mucous membranes, tongue, pharynx or larynx.

From the water-electrolyte balance: hyperkalemia (most likely with renal failure), hyponatremia (most often with a salt-free diet and the simultaneous use of diuretics.

From the urinary system: proteinuria, increased plasma urea and creatinine in blood plasma, acidosis.

From the hemopoietic system: in rare cases - neutropenia, agranulocytosis, thrombocytopenia and anemia, a positive test for antibodies to a nuclear antigen. In patients with normal renal function (CC less than 1.6 mg / dL) in the absence of other complicating factors, neutropenia was observed in 0.02% of cases.

From the digestive system: reversible and usually self-passing taste disorder, dry mouth, aphthous stomatitis rarely - abdominal pain, diarrhea, gum hyperplasia, hepatitis, increased levels of hepatic transaminases in blood plasma, hyperbilirubinemia.

Dermatological reactions: maculopapular rash, usually accompanied by itching and, in rare cases, fever, hyperemia, vesicular or bullous rashes, erythema (including Stevens-Johnson syndrome), photosensitivity.

From the side of the central nervous system and peripheral nervous system: headache, dizziness, ataxia, paresthesia, drowsiness, visual impairment.

Drug interaction

Diuretics, vasodilators, ganglion blockers, adrenergic blocking while taking the drug is potent.

Indomethacin and other NSAIDs, as well as clonidine, can reduce the antihypertensive effect of Kapoten.

Against the background of the simultaneous use of Kapoten with allopurinol and procainamide, neutropenia and / or Stevens-Johnson syndrome can be observed, however, cause and effect with

Overdose of

Symptoms: Marked decrease in blood pressure.

Treatment: Plasma replacement and hemodialysis are effective.

Storage Conditions

The product should be stored in a dry, out of the reach of children at room temperature.

Expiration

5 years.

Prescription terms from

pharmacies Prescription

lekarstvennaja form

tablets

Akrikhin CPC JSC, Russia



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