Ketonal solution for iv. and w / mouse. dosing 50 mg / ml 2 ml amp 10 pcs (Ketoprofen)

Latin name

Ketonal

Release form

Solution for injection

Packaging

In a dark glass ampoule, 2 ml of solution.

In a package of 10 ampoules.

Pharmacological action

Ketonal - NSAIDs, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects.

The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase.

In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and significantly inhibits neutrophil activity in patients with rheumatoid arthritis.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Indications

symptomatic treatment of painful inflammatory processes of various origins (including postoperative and post-traumatic pain, ischialgia, myalgia, , bruises and muscle strains, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, an acute attack of gout, tenosynovitis, bursitis)

symptomatic treatment of acute pain in inflammatory diseases of the musculoskeletal system (only for the / m)

Contraindications

gastrointestinal disease in the exacerbation phase

severe liver dysfunction

severe renal dysfunction

blood disorders (leukopenia, thrombocytopenia, disorders of the blood coagulation system) I

children under 15 years old

hemorrhoids and proctitis (for suppositories)

hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs (indications of a history of bronchospasm, urticaria, and urticaria).

Use during pregnancy and lactation

The use of Ketonal in the third trimester of pregnancy is contraindicated.

The use of Ketonal in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.

If you need to use Ketonal during lactation, you should decide on the termination of breastfeeding.

Composition of

1 ml of solution for iv and intramuscular administration contains: Ketoprofen 50 mg.

Excipients: propylene glycol, ethanol, benzyl alcohol, sodium hydroxide, water d / and.

Dosage and administration

The solution is administered in / m or / in.

Intramuscularly administered 100 mg 1-2 times / day.

IV infusion of ketoprofen is carried out only in a hospital setting.

Short intravenous infusion: 100-200 mg, diluted in 100 ml of 0.9% sodium chloride solution, administered within 0.5-1 hours. Repeated administration after 8 hours is possible.

Continuous iv infusion: 100-200 mg diluted in 500 ml of infusion solution (0.9% sodium chloride solution, lactate-containing Ringer's solution, 5% dextrose solution), administered within 8 hours. Re-administration after 8 hours is possible.

The maximum daily dose (including when using various dosage forms) is 200 mg.

Overdose

Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.

Treatment: gastric lavage, activated charcoal administration, symptomatic therapy.

The use of histamine H 2 receptor blockers, proton pump inhibitors, and prostaglandin inhibitors has been shown. There is no specific antidote.

Storage conditions

The drug should be stored at a temperature not exceeding 25 ° C.

Expiration

5 years.

Deystvuyuschee substances

Ketoprofen

Dosage form

Dosage form

solution for injection and infusion

Lek dd, Switzerland



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