Klenzit gel 0.1%, 15 g (adapalene)

Release form

Gel for external use.

Packing

in a tube of 15 g.

Pharmacological action

Acne treatment.

Adapalen is a retinoid metabolite, has comedonolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction with specific receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the “adhesion” of epithelial cells at the mouth of the sebaceous hair follicle and a decrease in the prerequisites for the formation of micro comedones.

Adapalene has an anti-inflammatory effect in vivo and in vitro by acting on inflammatory factors by inhibiting leukocyte migration in the focus of inflammation and arachidonic acid metabolism.

Adaptalene absorption through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.

Indications

Acne.

Contraindications

Hypersensitivity to one of the ingredients of the drug, pregnancy, lactation.

Precautions:

Dermatitis, eczema.

Use during pregnancy and lactation

The use of the drug during pregnancy and breastfeeding is not recommended.

Special instructions

Avoid contact with eyes and lips.

In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.

Avoid direct sunlight, as skin irritation may occur. Treatment can be continued if solar exposure is minimized (use of sunglasses and hats).

The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfumes or alcohol-containing products) is not recommended.

Adapalene, applied to the skin in the evening, can be combined with acne preparations used in the morning.

Composition

1 gram of gel contains:

Active ingredient:

Adapalen 1 mg.

Excipients:

Disodium edetate

Carbomer 940 (carbopol 940)

Propylene glycol

Methyl parahydroxybenzoate

Phenoxyethanol

Poloxamer 407

Sodium hydroxide purified.

Dosage and Administration

Externally. Before applying Klenzit gel, it is necessary to clean and dry the skin of the face. With a light touch, apply the gel evenly on the affected surface once a day before bedtime on clean, dry skin, avoiding contact with the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement after 3 months of treatment.

In some cases, due to short-term skin irritation, treatment may be suspended until the signs of irritation disappear. A second course of treatment is possible after consultation with a doctor.

Side effects

Skin irritation:

treatment must be stopped until the skin irritation disappears or the frequency of use is reduced.

Drug interaction

Since the drug does not interact with oxygen and does not break down under the influence of light, it is possible to treat acne with drugs such as clindamycin phosphate or benzoyl peroxide.

Overdose

Overdose is unlikely.

Storage Conditions

In a dark place at a temperature not exceeding 25 ° C.

Shelf life

3 years.

Do not use after expiration date.

Deystvuyushtee substance

Adapalene

Conditions of release from drugstores

Without prescription

Dosage form

gel for external use

Indications

Indications

Acne Rash

Glenmark Farmasьjutikalz LTD, India



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