Ko-Dalnev tablets 5 + 0.625 + 2 mg 30 pcs. pack (amlodipine, indapamide, Perindopril)

Latin name

Co-Dalneva

Indications

Arterial hypertension and / or coronary heart disease: stable angina pectoris in patients who require perindopril and amlodipine therapy.

Contraindications

Perindopril

hypersensitivity to perindopril or other ACE inhibitors

angioedema (Quincke's edema) in history (including the use of other ACE inhibitors) srdlkop age and / or not installed).

Amlodipine

hypersensitivity to amlodipine or other derivatives of dihydropyridine

severe arterial hypotension (SBP less than 90 mm Hg), shock, including cardiogenic

obstruction of the exit tract of the left ventricle (including severe stenosis of the aorta) with the exception of Prinzmetal angina)

hemodynamically unstable heart failure after acute myocardial infarction

age up to 18 years (efficacy and safety have not been established).

Dalneva®

hypersensitivity to excipients that are part of the

preparation renal failure (creatinine Cl less than 60 ml / min)

age up to 18 years (efficacy and safety have not been established).

Caution: liver failure chronic heart failure aortic and / or mitral stenosis hypertrophic obstructive cardiomyopathy (GOKMP) old age bilateral renal artery stenosis artery stenosis of a single functioning kidney renal failure (creatinine Cl less than 60 ml / min) systemic diseases of the connective tissue (including systemic lupus erythematosus, scleroderma), therapy with immunosuppressants, allopurinol, procainamide (risk of neutropenia, agranulocytosis), reduced BCC (taking diure Ikov, restricted diet salt, vomiting, diarrhea), atherosclerosis, cerebrovascular disease, renovascular hypertension, diabetes mellitus, the use of dantrolene, estramustine, potassium-sparing diuretics, potassium preparations, potassium-based salt substitutes food and drugs lithium hyperkalemia surgery / general anesthesia patients of the Negroid race hemodialysis using high-flow polyacrylonitrile membranes - the risk of anaphylactoid reactions before the LDL apheresis procedure with dextran sulfate, simultaneous desensitizing therapy with allergens (e.g., venomous membranes), .

Composition

1 tablet contains:

Active ingredients: amlodipine perindopril besilate erbumin A granule substance

Excipients: microcrystalline cellulose, starch pregelatinized, sodium carboxymethyl starch sodium carbamide, sodium dihydrocarbamide.

Dosage and Administration

Inside, one tablet once a day, preferably in the morning before meals.

The dose of the drug Dalnev® is selected after a previous titration of doses of the individual components of the drug - perindopril and amlodipine - in patients with arterial hypertension and stable angina pectoris.

If necessary, the dose of Dalnev® can be changed based on individual selection of doses of the individual components: (amlodipine 5 mg + perindopril 4 mg) or (amlodipine 10 mg + perindopril 4 mg), or (amlodipine 5 mg + perindopril 8 mg), or (amlodipine 10 mg + perindopril 8 mg).

The maximum daily dose is amlodipine 10 mg + perindopril 8 mg.

Impaired renal function. Dalnev® can be used in patients with Cl creatinine over 60 ml / min. The drug Dalneva® is contraindicated in patients with Cl creatinine less than 60 ml / min.

Such patients are advised to individually select the doses of perindopril and amlodipine. A change in the concentration of amlodipine in blood plasma does not correlate with the severity of renal failure.

Hepatic failure. Caution must be exercised when using the drug Dalnev® in patients with liver failure, because there are no recommendations on the doses of the drug in such patients.

Elderly patients. When using the drug Dalnev® in elderly patients, dose adjustment is not required.

Children and adolescents. Dalnev® should not be prescribed to children and adolescents under 18 years of age. because there is no data on the efficacy and safety of perindopril and amlodipine in these patient groups both in monotherapy and in combination therapy.

active substance

Amlodipine, Indapamide, Perindopril

Terms of delivery from

pharmacies Prescription

Dosage form

tablets

KRKA d.d. Novo mesto AO, Slovenia



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