Lamitor tablets 100 mg, 50 pcs. (Lamotrigine)
Special Price
$32.30
Regular Price
$38.00
In stock
SKU
newyork463801
Latin name
LAMITOR Buy Lamitor tablets 100 mg, 50 pcs. (Lamotrigine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
LAMITOR Buy Lamitor tablets 100 mg, 50 pcs. (Lamotrigine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
LAMITOR
Packing
10 pcs - blister packagings (5) - packs of cardboard.
Pharmacological action
Anticonvulsant (antiepileptic) drug. Blocker of voltage-gated sodium channels. It triggers a block of pulsed discharges in a neuronal culture and inhibits the excessive release of glutamate (amino acids that play a key role in generating epileptic seizures) along with inhibition of glutamate-induced effector pulses.
Pharmacokinetics
Absorption
After oral administration, lamotrigine is rapidly and completely absorbed from the gastrointestinal tract. Cmax in plasma is observed 2.5 ± 1.5 hours after oral administration. The time to reach Cmax is somewhat longer if the drug is taken after a meal, but the degree of absorption remains unchanged. Pharmacokinetics is linear in nature up to a dose of 450 mg - the maximum single dose that has been investigated. There are significant individual differences in the Cmax values of the drug, but individual concentrations differ very little.
Distribution of
Plasma protein binding is approximately 55%.
Metabolism
Metabolized in the liver to form predominantly glucuronides.
Excretion of
T1 / 2 in healthy adults is 24-35 hours.
Average clearance in healthy people is 39 ± 14 ml / min.
Lamotrigine is excreted in the urine as glucuronides. Less than 10% is excreted unchanged in urine. Only 2% of metabolic products are excreted in the feces.
Pharmacokinetics in special clinical cases
T1 / 2 lamotrigine is largely dependent on concomitant drug therapy.
T1 / 2 lamotrigine decreases to 14 hours when combined with drugs, inducing the activity of isoenzymes of the cytochrome P450 system, such as carbamazepine and phenytoin, and increases on average up to about 70 hours in case of combined use with sodium valproate.
T1 / 2 lamotrigine in children is usually shorter than in adults. T1 / 2 in children is approximately 7 hours when taken with drugs that induce isoenzyme activity, such as carbamazepine, phenytoin, phenobarbital and primidone. T1 / 2 increases to 45-55 hours when combined with sodium valproate.
A study of the pharmacokinetics of lamotrigine in single doses in patients with kidney disease suggests that the pharmacokinetic parameters vary slightly, but the concentration of the main metabolite in the form of glucuronide increases almost 8 times due to a decrease in renal clearance.
Indications
Lamitor is recommended as monotherapy and adjuvant therapy for adults and children over 12 years of age:
simple partial convulsive seizures
complex partial seizure seizures
secondary generalized tonic-clonic seizures seizures
primary-generalized general-clonics generalized generalized abscesses atypical
myoclonic seizures
seizures resistant to other antiepileptic drugs of any type.
Lamitor is also used as adjuvant therapy for children aged 2 to 12 years.
Contraindications
severe liver dysfunction
hypersensitivity to lamotrigine and other components of the drug.
Use in cases of impaired liver function
Contraindicated in severely impaired liver function.
Use for impaired renal function
In patients with impaired renal function in the terminal stage of the disease, an accumulation of the metabolite in the form of glucuronide should be expected. Therefore, if necessary, the appointment of such patients should be careful.
Use in children
The initial dose of Lamitor for children from 2 to 12 years old who are not taking sodium valproate, but taking other antiepileptic drugs that induce isoenzymes is 2 mg / kg / day (in 2 doses) during the first 2 weeks and 5 mg / kg / day (in 2 doses) for the next 2 weeks. The maintenance dose is 5-15 mg / kg / day (in 2 divided doses).
The initial dose of Lamitor for children taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 0.2 mg / kg 1 time / day for the first 2 weeks, then 0.5 mg / kg 1 time / day for the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 1-5 mg / kg (in 1 or 2 doses).
Use during pregnancy and lactation
The drug should not be prescribed during pregnancy and lactation, unless when the expected benefits of therapy for the mother outweigh the potential risk to the fetus and the baby.
Use during pregnancy and lactation
The drug should not be prescribed during pregnancy and lactation, unless when the expected benefits of therapy for the mother outweigh the potential risk to the fetus and the baby.
Composition
Tablets 1 tab.
lamotrigine * 25 mg
- - 50 mg
- - 100 mg
* - non-proprietary international name recommended by the WHO in the Russian Federation the spelling of the international name - lamotrigine is accepted.
Dosage and administration of
Initial dose of Lamitor for adults and children over 12 years of age, not taking sodium valproate, but taking other antiepileptic drugs that induce isoenzymes, is 50 mg 1 time / day. during the first 2 weeks and 100 mg / day. (in 2 divided doses) over the next 2 weeks. Then the dose should be increased to 200-400 mg / day. (in 2 doses).
The initial dose of Lamitor for patients taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 25 mg every other day for the first 2 weeks and then 25 mg 1 time / day. over the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 100-200 mg (in 1 or 2 doses).
The initial dose of Lamitor for children from 2 to 12 years old who do not take sodium valproate, but who take other antiepileptic drugs that induce isoenzymes, is 2 mg / kg / day (in 2 divided doses) during the first 2 weeks and 5 mg / kg / day. (in 2 divided doses) over the next 2 weeks. The maintenance dose is 5-15 mg / kg / day. (In 2 doses).
The initial dose of Lamitor for children taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 0.2 mg / kg 1 time / day. during the first 2 weeks, then 0.5 mg / kg 1 time / day. over the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 1-5 mg / kg (in 1 or 2 doses).
Side effects
Side effects, noted when prescribing Lamitor as monotherapy
From the side of the central nervous system: dizziness, headache, drowsiness, sleep disturbance, increased fatigue.
From the digestive system: nausea.
Allergic reactions: maculopapular skin rash (2%), most often occurs in the first 4 weeks after the start of treatment and disappears after discontinuation of the drug. In some cases, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis.
Side effects noted when prescribing Lamitor as an additional therapy to standard antiepileptic drugs
From the side of the central nervous system: dizziness, headache, drowsiness, imbalance, increased fatigue, irritability, aggressiveness, tremor, confusion.
From the side of the organ of vision: diplopia, visual impairment.
From the hemopoietic system: neutropenia, leukopenia.
From the digestive system: nausea, vomiting, dyspeptic symptoms.
Drug Interaction
When used concomitantly with antiepileptic drugs that induce isoenzymes of the liver (phenytoin, carbamazepine, phenobarbital, primidone), the metabolism of Lamitor increases, which may require an increase in its metabolism.
Sodium valproate, which competes with lamotrigine for metabolizing liver isoenzymes, inhibits its metabolism. There is no evidence that Lamitir is able to induce or inhibit liver isoenzymes metabolizing other drugs. The laminator can induce its own metabolism, but this effect is very minor and does not cause serious clinical manifestations.
Although changes in the concentration of other antiepileptic drugs in plasma have been observed in some patients, controlled studies have not confirmed the effects of Lamitor on the levels of concomitantly administered antiepileptic drugs in blood plasma. In vitro studies indicate that Lamitor does not compete with other antiepileptic drugs for plasma protein binding sites.
Overdose
Symptoms: nystagmus, ataxia, dizziness, drowsiness, headache, nausea, loss of consciousness, coma.
Treatment: gastric lavage, activated charcoal intake. If necessary, conduct symptomatic therapy.
Storage conditions
The drug should be stored in a place protected from light and moisture at a temperature not exceeding 30 ° C.
Expiration
2 years.
Deystvuyuschee substances
Lamotrigine
Dosage
form Dosage form
tablets
Torrent, India
Lamitor tablets 100 mg, 50 pcs. (Lamotrigine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Lamitor tablets 100 mg, 50 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
LAMITOR
Packing
10 pcs - blister packagings (5) - packs of cardboard.
Pharmacological action
Anticonvulsant (antiepileptic) drug. Blocker of voltage-gated sodium channels. It triggers a block of pulsed discharges in a neuronal culture and inhibits the excessive release of glutamate (amino acids that play a key role in generating epileptic seizures) along with inhibition of glutamate-induced effector pulses.
Pharmacokinetics
Absorption
After oral administration, lamotrigine is rapidly and completely absorbed from the gastrointestinal tract. Cmax in plasma is observed 2.5 ± 1.5 hours after oral administration. The time to reach Cmax is somewhat longer if the drug is taken after a meal, but the degree of absorption remains unchanged. Pharmacokinetics is linear in nature up to a dose of 450 mg - the maximum single dose that has been investigated. There are significant individual differences in the Cmax values of the drug, but individual concentrations differ very little.
Distribution of
Plasma protein binding is approximately 55%.
Metabolism
Metabolized in the liver to form predominantly glucuronides.
Excretion of
T1 / 2 in healthy adults is 24-35 hours.
Average clearance in healthy people is 39 ± 14 ml / min.
Lamotrigine is excreted in the urine as glucuronides. Less than 10% is excreted unchanged in urine. Only 2% of metabolic products are excreted in the feces.
Pharmacokinetics in special clinical cases
T1 / 2 lamotrigine is largely dependent on concomitant drug therapy.
T1 / 2 lamotrigine decreases to 14 hours when combined with drugs, inducing the activity of isoenzymes of the cytochrome P450 system, such as carbamazepine and phenytoin, and increases on average up to about 70 hours in case of combined use with sodium valproate.
T1 / 2 lamotrigine in children is usually shorter than in adults. T1 / 2 in children is approximately 7 hours when taken with drugs that induce isoenzyme activity, such as carbamazepine, phenytoin, phenobarbital and primidone. T1 / 2 increases to 45-55 hours when combined with sodium valproate.
A study of the pharmacokinetics of lamotrigine in single doses in patients with kidney disease suggests that the pharmacokinetic parameters vary slightly, but the concentration of the main metabolite in the form of glucuronide increases almost 8 times due to a decrease in renal clearance.
Indications
Lamitor is recommended as monotherapy and adjuvant therapy for adults and children over 12 years of age:
simple partial convulsive seizures
complex partial seizure seizures
secondary generalized tonic-clonic seizures seizures
primary-generalized general-clonics generalized generalized abscesses atypical
myoclonic seizures
seizures resistant to other antiepileptic drugs of any type.
Lamitor is also used as adjuvant therapy for children aged 2 to 12 years.
Contraindications
severe liver dysfunction
hypersensitivity to lamotrigine and other components of the drug.
Use in cases of impaired liver function
Contraindicated in severely impaired liver function.
Use for impaired renal function
In patients with impaired renal function in the terminal stage of the disease, an accumulation of the metabolite in the form of glucuronide should be expected. Therefore, if necessary, the appointment of such patients should be careful.
Use in children
The initial dose of Lamitor for children from 2 to 12 years old who are not taking sodium valproate, but taking other antiepileptic drugs that induce isoenzymes is 2 mg / kg / day (in 2 doses) during the first 2 weeks and 5 mg / kg / day (in 2 doses) for the next 2 weeks. The maintenance dose is 5-15 mg / kg / day (in 2 divided doses).
The initial dose of Lamitor for children taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 0.2 mg / kg 1 time / day for the first 2 weeks, then 0.5 mg / kg 1 time / day for the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 1-5 mg / kg (in 1 or 2 doses).
Use during pregnancy and lactation
The drug should not be prescribed during pregnancy and lactation, unless when the expected benefits of therapy for the mother outweigh the potential risk to the fetus and the baby.
Use during pregnancy and lactation
The drug should not be prescribed during pregnancy and lactation, unless when the expected benefits of therapy for the mother outweigh the potential risk to the fetus and the baby.
Composition
Tablets 1 tab.
lamotrigine * 25 mg
- - 50 mg
- - 100 mg
* - non-proprietary international name recommended by the WHO in the Russian Federation the spelling of the international name - lamotrigine is accepted.
Dosage and administration of
Initial dose of Lamitor for adults and children over 12 years of age, not taking sodium valproate, but taking other antiepileptic drugs that induce isoenzymes, is 50 mg 1 time / day. during the first 2 weeks and 100 mg / day. (in 2 divided doses) over the next 2 weeks. Then the dose should be increased to 200-400 mg / day. (in 2 doses).
The initial dose of Lamitor for patients taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 25 mg every other day for the first 2 weeks and then 25 mg 1 time / day. over the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 100-200 mg (in 1 or 2 doses).
The initial dose of Lamitor for children from 2 to 12 years old who do not take sodium valproate, but who take other antiepileptic drugs that induce isoenzymes, is 2 mg / kg / day (in 2 divided doses) during the first 2 weeks and 5 mg / kg / day. (in 2 divided doses) over the next 2 weeks. The maintenance dose is 5-15 mg / kg / day. (In 2 doses).
The initial dose of Lamitor for children taking sodium valproate in combination with other antiepileptic drugs that induce isoenzymes is 0.2 mg / kg 1 time / day. during the first 2 weeks, then 0.5 mg / kg 1 time / day. over the next 2 weeks. Then the dose should be increased to achieve the optimal therapeutic effect. The maintenance dose is 1-5 mg / kg (in 1 or 2 doses).
Side effects
Side effects, noted when prescribing Lamitor as monotherapy
From the side of the central nervous system: dizziness, headache, drowsiness, sleep disturbance, increased fatigue.
From the digestive system: nausea.
Allergic reactions: maculopapular skin rash (2%), most often occurs in the first 4 weeks after the start of treatment and disappears after discontinuation of the drug. In some cases, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis.
Side effects noted when prescribing Lamitor as an additional therapy to standard antiepileptic drugs
From the side of the central nervous system: dizziness, headache, drowsiness, imbalance, increased fatigue, irritability, aggressiveness, tremor, confusion.
From the side of the organ of vision: diplopia, visual impairment.
From the hemopoietic system: neutropenia, leukopenia.
From the digestive system: nausea, vomiting, dyspeptic symptoms.
Drug Interaction
When used concomitantly with antiepileptic drugs that induce isoenzymes of the liver (phenytoin, carbamazepine, phenobarbital, primidone), the metabolism of Lamitor increases, which may require an increase in its metabolism.
Sodium valproate, which competes with lamotrigine for metabolizing liver isoenzymes, inhibits its metabolism. There is no evidence that Lamitir is able to induce or inhibit liver isoenzymes metabolizing other drugs. The laminator can induce its own metabolism, but this effect is very minor and does not cause serious clinical manifestations.
Although changes in the concentration of other antiepileptic drugs in plasma have been observed in some patients, controlled studies have not confirmed the effects of Lamitor on the levels of concomitantly administered antiepileptic drugs in blood plasma. In vitro studies indicate that Lamitor does not compete with other antiepileptic drugs for plasma protein binding sites.
Overdose
Symptoms: nystagmus, ataxia, dizziness, drowsiness, headache, nausea, loss of consciousness, coma.
Treatment: gastric lavage, activated charcoal intake. If necessary, conduct symptomatic therapy.
Storage conditions
The drug should be stored in a place protected from light and moisture at a temperature not exceeding 30 ° C.
Expiration
2 years.
Deystvuyuschee substances
Lamotrigine
Dosage
form Dosage form
tablets
Torrent, India
Lamitor tablets 100 mg, 50 pcs. (Lamotrigine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Lamitor tablets 100 mg, 50 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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