Levofloxacin-Teva tablets coated.pl.ob. 500 mg 14 pcs. (levofloxacin)

release

tablets, film-coated



packaging 14 pcs

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to levofloxacin: acute bacterial sinusitis

exacerbation of chronic bronchitis

community-acquired pneumonia

complicated infections of the kidneys and urinary tract infections of the skin, urinary tract infections, urinary tract infections

Special instructions

When using levofloxacin, there have been cases of tendonitis, which affects mainly the Achilles tendon and can lead to its rupture. In elderly patients, as well as with concomitant use of corticosteroids, the likelihood of tendonitis and tendon rupture with levofloxacin increases. If suspected of tendonitis, levofloxacin should be immediately withdrawn and appropriate treatment should be initiated, ensuring dormancy in the affected area.

If pseudomembranous colitis is suspected (the occurrence of diarrhea, in particular severe and / or blood), levofloxacin should be stopped immediately and appropriate treatment should be started.

During treatment with levofloxacin, seizures may develop in patients with previous brain damage (including with a stroke or severe brain injury).

With the use of quinolones in patients with glucose-6-phosphate dehydrogenase deficiency, erythrocyte hemolysis is possible.

If it is necessary to use levofloxacin in patients with diabetes mellitus, it is necessary to control the concentration of glucose in the blood.

Sometimes, even after taking the first dose of levofloxacin, the development of severe, potentially dangerous hypersensitivity reactions (angioedema, anaphylactic shock) is possible.

Although photosensitization is very rare with levofloxacin, patients should avoid exposure to the sun or UV radiation to prevent it from developing.

With the simultaneous use of levofloxacin and indirect anticoagulants, it is necessary to monitor the state of the blood coagulation system.

When taking fluoroquinolones, including levofloxacin, the development of psychotic reactions is possible, which, very rarely, with progression can lead to suicidal thoughts and potentially dangerous behavior. With the development of such phenomena, the drug should be discontinued.

When applying levofloxacin in patients who have predisposing factors for lengthening the QT interval, it is necessary to conduct an electrocardiogram study before and during treatment with levofloxacin.

When taking fluoroquinolones, there have been cases of the development of sensory or sensorimotor peripheral neuropathy. To prevent the development of irreversible effects in the development of symptoms of peripheral neuropathy, levofloxacin should be immediately canceled.

When taking levofloxacin in patients, false-positive test results for the presence of opiates in the urine are possible. More specific methods should be used to confirm a positive test result.

There are reports of rare cases of liver failure during treatment with levofloxacin, primarily in patients with severe diseases such as sepsis. When symptoms of liver dysfunction appear, such as decreased appetite, jaundice, dark urine, itching or tenderness of the abdominal wall upon palpation, levofloxacin should be discontinued.

When prescribing the drug to elderly patients, it should be borne in mind that patients in this group often have impaired renal function.

Composition

1 tablet contains: the active substance levofloxacin (levofloxacin hemihydrate) 500.00 (512.46) mg excipients: silicon dioxide colloidal 12.00 mg, hyprolysis 28.00 mg, sodium carboxymethyl starch, type A 55.00 mg, talc 55.20 mg, croscarmellose sodium 20.60 mg, magnesium stearate 6.74 mg, shell Opadry 15B26688 brown (hypromellose 2910 3 CP 4.760 mg, hypromellose 2910 6 CP 4.760 mg, titanium dioxide E171 3.044 mg, macrogol-400 1,120 mg, polysorbate-800,140 mg, iron dye oxide yellow E172 0.120 mg, iron dye oxide red E172 0.043 mg, iron dye black oxide E172 0.013 mg).

Dosage and administration of

Levofloxacin-Teva taken orally 1-2 times a day. The dose and duration of treatment are determined by the nature and severity of the infection, as well as the sensitivity of the alleged pathogen. Tablets should be taken without chewing and drinking plenty of fluids (from? To 1 cup). When choosing doses, tablets can be broken along the dividing groove into equal parts. The drug can be taken before meals or at any time between meals.

Treatment with Levofloxacin-Teva is recommended to continue for at least 48-72 hours after normalization of body temperature or after significant pathogen eradication.

Acute bacterial sinusitis: 1 tablet (500 mg) once a day for 10-14 days.

Acute bronchitis and exacerbation of chronic bronchitis:? -1 tablet (250-500 mg) 1 time per day for 7-10 days.

Community-acquired pneumonia: 1 tablet (500 mg) 1-2 times a day for 7-14 days.

Complicated infectious diseases of the kidneys and urinary tract, including pyelonephritis: by ? tablet (250 mg) 1 time per day for 7-10 days.

Chronic bacterial prostatitis: 1 tablet (500 mg) once a day for 28 days.

Infections of the skin and soft tissues: 1 tablet (500 mg) 1-2 times a day for 7-14 days.

Patients with impaired hepatic function do not require dosage adjustment.

Patients with impaired renal function (CC less than 50 ml / min) require correction of the dosage regimen depending on the value of CC.

Drug interaction

Absorption of levofloxacin is significantly reduced when used simultaneously with sucralfate, magnesium or aluminum-containing antacids, and also with iron salts (the interval between taking levofloxacin and these drugs should be at least 2 hours). No interactions were detected with calcium carbonate.

Quinolones can enhance the ability of drugs (including theophylline) to lower the threshold of convulsive readiness. With concomitant use with fenbufen, higher levofloxacin concentrations (13%) were observed than with monotherapy.

Excretion of levofloxacin slows down under the action of cimetidine (24%) and probenecid (34%).

Levofloxacin causes a slight increase in T1 / 2 of cyclosporine.

Concomitant use with glucocorticosteroids (GCS) increases the risk of tendon rupture.

Concomitant use of levofloxacin with oral anticoagulants increases the time of coagulation and / or bleeding.

Levofloxacin with simultaneous use with antiarrhythmic drugs of classes IA and III, tricyclic antidepressants, macrolides can cause an extension of the QT interval.

Overdose

Symptoms: nausea, erosive lesions of the mucous membranes of the gastrointestinal tract, dizziness, blurred consciousness and seizures of the type of epileptic seizures.

Treatment: conduct symptomatic therapy, ECG monitoring. There is no specific antidote. Hemodialysis is not effective.

Storage Conditions

At a temperature not exceeding 25 ° C in a dark place. Keep out of reach of children.

Expiration

3 years.

active substance

Levofloxacin

Terms leave through pharmacies

In retseptu

lekarstvennaja form

tablets

Prescribing

Adults prescribed by a doctor

Teva Pharmaceutical Enterprise Co., Ltd., Israel



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