lisinotone tablets 10 mg 28 pcs. (Lisinopril)
Special Price
$20.40
Regular Price
$24.00
In stock
SKU
newyork463559
Release form
Tablets. Buy lisinotone tablets 10 mg 28 pcs. (Lisinopril) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Tablets. Buy lisinotone tablets 10 mg 28 pcs. (Lisinopril) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Tablets.
Packing
14 pcs. - blisters (2) - packs of cardboard.
Pharmacological action
Lysinotone, an ACE inhibitor, reduces the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone. Reduces the degradation of bradykinin and increases the synthesis of prostaglandins. It reduces OPSS, blood pressure, preload, pressure in the pulmonary capillaries, causes an increase in minute blood volume and increased myocardial tolerance to stress in patients with chronic heart failure. Expands arteries to a greater extent than veins. Some effects are explained by the effect on tissue renin-angiotensin systems. With prolonged use, hypertrophy of the myocardium and walls of the arteries of the resistive type decreases. Improves blood supply to the ischemic myocardium.
ACE inhibitors lengthen life expectancy in patients with chronic heart failure, slow the progression of left ventricular dysfunction in patients after myocardial infarction without clinical manifestations of heart failure.
After a single dose of the drug, the antihypertensive effect develops after 1 hour, reaches a maximum after 6-7 hours and lasts for 24 hours. The duration of the effect also depends on the size of the dose taken. With arterial hypertension, the effect is observed in the first days after the start of treatment, a stable effect develops after 1-2 months. With a sharp withdrawal of the drug, no marked increase in blood pressure was observed.
Lysinotone reduces albuminuria. In patients with hyperglycemia, it helps normalize the function of damaged glomerular endothelium. It does not affect the blood glucose concentration in patients with diabetes mellitus and does not lead to an increase in cases of hypoglycemia.
Indications
- Arterial hypertension (as monotherapy or in combination with other antihypertensive drugs).
- Chronic heart failure (as part of combination therapy for patients taking digitalis and / or diuretics).
- An early period of acute myocardial infarction (in the first 24 hours) with stable hemodynamics (to maintain hemodynamic parameters and prevent left ventricular dysfunction and heart failure).
Contraindications
- History of angioedema (including when using ACE inhibitors).
- Hereditary Quincke's edema.
- Age under 18 years of age (efficacy and safety not established).
- Hypersensitivity to lisinopril or other ACE inhibitors.
With caution, the drug should be prescribed for severe renal dysfunction, bilateral renal artery stenosis or single stenosis of the artery of a single kidney with progressive azotemia, a condition after kidney transplantation, renal failure, azotemia, hyperkalemia, aortic stenosis, hypertrophic obstructive hyperemia, hypertrophic hypertension, cerebrovascular diseases (including cerebrovascular insufficiency), coronary heart disease, coronary deficiency, autoimmune systemic diseases of the connective tissue (including scleroderma, systemic lupus erythematosus), inhibition of bone marrow hematopoiesis, hypovolemic conditions (including as a result of diarrhea, vomiting) for patients on a sodium-restricted diet, elderly patients.
Use during pregnancy and lactation
The use of lisinotone during pregnancy is contraindicated. Lisinopril crosses the placenta. When pregnancy is established, the drug should be discontinued as soon as possible. Acceptance of ACE inhibitors in the II and III trimesters of pregnancy has an adverse effect on the fetus (a pronounced decrease in blood pressure, renal failure, hyperkalemia, cranial hypoplasia, intrauterine death are possible). There are no data on the negative effects of the drug on the fetus if used in the first trimester. For newborns and infants who underwent intrauterine exposure to ACE inhibitors, it is recommended to establish careful monitoring to timely detect a pronounced decrease in blood pressure, oliguria, hyperkalemia.
There is no data on the absorption of lisinopril into breast milk. If necessary, the appointment of the drug during lactation, breastfeeding should be discontinued.
Special instructions
The most pronounced decrease in blood pressure occurs with a decrease in fluid volume caused by diuretic therapy, reduced salt in the diet, dialysis, diarrhea, or vomiting. In chronic heart failure with simultaneous renal failure or without it, a marked decrease in blood pressure is possible. A more pronounced decrease in blood pressure is detected in patients with a severe stage of chronic heart failure, as a result of the use of diuretics in high doses, hyponatremia, or impaired renal function. In such patients, treatment with Lisinotone should be started under the strict supervision of a physician (with caution, select a dose of the drug and diuretics).
Similar rules should be followed when prescribing Lysinotone to patients with coronary heart disease, cerebrovascular insufficiency, in which a sharp decrease in blood pressure can lead to myocardial infarction or stroke.
Transient hypotensive reaction is not a contraindication for taking the next dose of the drug.
When using Lysinotone in some patients with chronic heart failure, but with normal or low blood pressure, a decrease in blood pressure may occur, which is usually not a reason for stopping treatment.
Before starting treatment with lisinotone, if possible, normalize the concentration of sodium and / or make up for the lost volume of fluid, carefully monitor the effect of the initial dose of lysinotone on the patient.
In case of stenosis of the renal artery (especially with bilateral stenosis or in the presence of stenosis of the artery of a single kidney), as well as circulatory failure due to lack of sodium and / or fluid, the use of lysinotone can lead to impaired renal function, acute renal failure, which usually occurs irreversible after discontinuation of the drug.
In acute myocardial infarction, the use of standard therapy (thrombolytics, acetylsalicylic acid, beta-blockers) is indicated. It is possible to use lysinotone in conjunction with the on / in the introduction or with the use of therapeutic transdermal systems of nitroglycerin.
With extensive surgical interventions, as well as with the use of other drugs that cause a decrease in blood pressure, lisinopril, blocking the formation of angiotensin II, can cause a pronounced unpredictable decrease in blood pressure.
In elderly patients, the use of standard doses leads to a higher concentration of the drug in the blood, therefore special care is required when determining the dose, despite the fact that there are no differences in the antihypertensive effect of Lysinotone in elderly and young patients.
Since the potential risk of agranulocytosis cannot be ruled out, periodic monitoring of the blood picture is required.
When using the drug under dialysis conditions with a polyacryl-nitrile membrane, anaphylactic shock can occur, therefore, either a different type of dialysis membrane or the use of other antihypertensive agents is recommended.
Effect on the ability to drive vehicles and control mechanisms
There is no data on the effect of lisinopril on the ability to drive vehicles and mechanisms, but keep in mind that dizziness is possible, therefore caution should be exercised.
Composition
Round tablets, biconvex, white,.
Active ingredient: - Lisinopril (in the form of dihydrate) 10 mg in 1 tablet.
Excipients: - Mannitol.
- Calcium hydrogen phosphate dihydrate.
- Pregelatinized corn starch.
- Croscarmellose sodium.
- Magnesium Stearate.
Dosage and administration of
Arterial hypertension For arterial hypertension, patients not receiving other antihypertensive drugs are prescribed 5 mg 1 time / day. If there is no effect, the dose is increased every 2-3 days by 5 mg to an average therapeutic dose of 20-40 mg / day (increasing the dose of more than 40 mg / day usually does not lead to a further decrease in blood pressure). The usual daily maintenance dose is 20 mg. The maximum daily dose is 40 mg. The full effect usually develops after 2-4 weeks from the start of treatment, which should be taken into account when increasing the dose. With insufficient clinical effect, it is possible to combine the drug with other antihypertensive drugs. If the patient received preliminary treatment with diuretics, then their reception must be stopped 2-3 days before the start of the use of lisinotone. If it is impossible to cancel diuretics, then the initial dose of Lysinotone should not exceed
Side effects
From the cardiovascular system: often - orthostatic hypotension, chest pain (1-3%) rarely (From the central nervous system: often - dizziness, headache (5-6%), weakness rarely (From digestive system: often - nausea, vomiting, diarrhea rarely (From the respiratory system: often (3%) - dry cough.
From the hematopoietic system: possibly - leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with prolonged treatment - a slight decrease in hemoglobin concentration and hematocrit, erythrocytopenia.s rdlkp On the part of the immune system: (0.1%) angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities) rarely (From the urinary system: rarely (Dermatological reactions: often - a skin rash is rare (Laboratory parameters: hyperkalemia, azotemia, hyperuricemia, hyperbilirubinemia, increased activity of liver enzymes (especially if there is a history of kidney disease, diabetes mellitus and renovascular hypertension).
Other: rarely (
Drug Interactions
When used simultaneously with diuretics, lisinopril decreases potassium excretion.
With extreme caution, lisinotone should be prescribed simultaneously with potassium-sparing diuretics (spironolactone, triamteren, amiloride), potassium, salt substitutes containing potassium, as the risk of developing hyperkalemia increases, especially with impaired renal function. Therefore, these combinations should be prescribed only on the basis of an individual decision of the attending physician with regular monitoring of serum potassium levels and renal function.
When used simultaneously with diuretics and other antihypertensive drugs, an additive antihypertensive effect develops.
When used simultaneously with NSAIDs (including indomethacin), estrogens, and also adrenostimulants, the antihypertensive effect of lisinopril is reduced.
When used simultaneously with lithium, lithium excretion may decrease, therefore, serum lithium concentration should be regularly monitored.
With simultaneous use with antacids and colestyramine, absorption of lisinopril from the gastrointestinal tract is reduced.
With the simultaneous use of ethanol enhances the effect of lisinopril.
overdose
Symptoms: marked decrease in blood pressure, dry mouth, drowsiness, delayed urination, constipation, anxiety, irritability (occur when taking a single dose of 50 mg).
Treatment: carry out symptomatic therapy if necessary (in / in the introduction of fluid, control and normalization of blood pressure, water-electrolyte balance).
Lisinopril is excreted by hemodialysis.
Storage Conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life
3 years.
eystvuyushtee substance
Lisinopril
Terms and conditions
prescription
dosage form
tablets
Possible product names
Lysinotone 10mg No. 28
LYSINOTON 0.01 N28 TABLE
Lysinotone 10mg Tab. X28 (R)
Lysinotone 10mg Tab. X28 (R) /! Until 03.11g /
Lisinoton tab. 10mg x 28
Actavis Ltd, Iceland
lisinotone tablets 10 mg 28 pcs. (Lisinopril) florida in pharmacy online. Cheap price, instruction, side effects, dosage. lisinotone tablets 10 mg 28 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Tablets.
Packing
14 pcs. - blisters (2) - packs of cardboard.
Pharmacological action
Lysinotone, an ACE inhibitor, reduces the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone. Reduces the degradation of bradykinin and increases the synthesis of prostaglandins. It reduces OPSS, blood pressure, preload, pressure in the pulmonary capillaries, causes an increase in minute blood volume and increased myocardial tolerance to stress in patients with chronic heart failure. Expands arteries to a greater extent than veins. Some effects are explained by the effect on tissue renin-angiotensin systems. With prolonged use, hypertrophy of the myocardium and walls of the arteries of the resistive type decreases. Improves blood supply to the ischemic myocardium.
ACE inhibitors lengthen life expectancy in patients with chronic heart failure, slow the progression of left ventricular dysfunction in patients after myocardial infarction without clinical manifestations of heart failure.
After a single dose of the drug, the antihypertensive effect develops after 1 hour, reaches a maximum after 6-7 hours and lasts for 24 hours. The duration of the effect also depends on the size of the dose taken. With arterial hypertension, the effect is observed in the first days after the start of treatment, a stable effect develops after 1-2 months. With a sharp withdrawal of the drug, no marked increase in blood pressure was observed.
Lysinotone reduces albuminuria. In patients with hyperglycemia, it helps normalize the function of damaged glomerular endothelium. It does not affect the blood glucose concentration in patients with diabetes mellitus and does not lead to an increase in cases of hypoglycemia.
Indications
- Arterial hypertension (as monotherapy or in combination with other antihypertensive drugs).
- Chronic heart failure (as part of combination therapy for patients taking digitalis and / or diuretics).
- An early period of acute myocardial infarction (in the first 24 hours) with stable hemodynamics (to maintain hemodynamic parameters and prevent left ventricular dysfunction and heart failure).
Contraindications
- History of angioedema (including when using ACE inhibitors).
- Hereditary Quincke's edema.
- Age under 18 years of age (efficacy and safety not established).
- Hypersensitivity to lisinopril or other ACE inhibitors.
With caution, the drug should be prescribed for severe renal dysfunction, bilateral renal artery stenosis or single stenosis of the artery of a single kidney with progressive azotemia, a condition after kidney transplantation, renal failure, azotemia, hyperkalemia, aortic stenosis, hypertrophic obstructive hyperemia, hypertrophic hypertension, cerebrovascular diseases (including cerebrovascular insufficiency), coronary heart disease, coronary deficiency, autoimmune systemic diseases of the connective tissue (including scleroderma, systemic lupus erythematosus), inhibition of bone marrow hematopoiesis, hypovolemic conditions (including as a result of diarrhea, vomiting) for patients on a sodium-restricted diet, elderly patients.
Use during pregnancy and lactation
The use of lisinotone during pregnancy is contraindicated. Lisinopril crosses the placenta. When pregnancy is established, the drug should be discontinued as soon as possible. Acceptance of ACE inhibitors in the II and III trimesters of pregnancy has an adverse effect on the fetus (a pronounced decrease in blood pressure, renal failure, hyperkalemia, cranial hypoplasia, intrauterine death are possible). There are no data on the negative effects of the drug on the fetus if used in the first trimester. For newborns and infants who underwent intrauterine exposure to ACE inhibitors, it is recommended to establish careful monitoring to timely detect a pronounced decrease in blood pressure, oliguria, hyperkalemia.
There is no data on the absorption of lisinopril into breast milk. If necessary, the appointment of the drug during lactation, breastfeeding should be discontinued.
Special instructions
The most pronounced decrease in blood pressure occurs with a decrease in fluid volume caused by diuretic therapy, reduced salt in the diet, dialysis, diarrhea, or vomiting. In chronic heart failure with simultaneous renal failure or without it, a marked decrease in blood pressure is possible. A more pronounced decrease in blood pressure is detected in patients with a severe stage of chronic heart failure, as a result of the use of diuretics in high doses, hyponatremia, or impaired renal function. In such patients, treatment with Lisinotone should be started under the strict supervision of a physician (with caution, select a dose of the drug and diuretics).
Similar rules should be followed when prescribing Lysinotone to patients with coronary heart disease, cerebrovascular insufficiency, in which a sharp decrease in blood pressure can lead to myocardial infarction or stroke.
Transient hypotensive reaction is not a contraindication for taking the next dose of the drug.
When using Lysinotone in some patients with chronic heart failure, but with normal or low blood pressure, a decrease in blood pressure may occur, which is usually not a reason for stopping treatment.
Before starting treatment with lisinotone, if possible, normalize the concentration of sodium and / or make up for the lost volume of fluid, carefully monitor the effect of the initial dose of lysinotone on the patient.
In case of stenosis of the renal artery (especially with bilateral stenosis or in the presence of stenosis of the artery of a single kidney), as well as circulatory failure due to lack of sodium and / or fluid, the use of lysinotone can lead to impaired renal function, acute renal failure, which usually occurs irreversible after discontinuation of the drug.
In acute myocardial infarction, the use of standard therapy (thrombolytics, acetylsalicylic acid, beta-blockers) is indicated. It is possible to use lysinotone in conjunction with the on / in the introduction or with the use of therapeutic transdermal systems of nitroglycerin.
With extensive surgical interventions, as well as with the use of other drugs that cause a decrease in blood pressure, lisinopril, blocking the formation of angiotensin II, can cause a pronounced unpredictable decrease in blood pressure.
In elderly patients, the use of standard doses leads to a higher concentration of the drug in the blood, therefore special care is required when determining the dose, despite the fact that there are no differences in the antihypertensive effect of Lysinotone in elderly and young patients.
Since the potential risk of agranulocytosis cannot be ruled out, periodic monitoring of the blood picture is required.
When using the drug under dialysis conditions with a polyacryl-nitrile membrane, anaphylactic shock can occur, therefore, either a different type of dialysis membrane or the use of other antihypertensive agents is recommended.
Effect on the ability to drive vehicles and control mechanisms
There is no data on the effect of lisinopril on the ability to drive vehicles and mechanisms, but keep in mind that dizziness is possible, therefore caution should be exercised.
Composition
Round tablets, biconvex, white,.
Active ingredient: - Lisinopril (in the form of dihydrate) 10 mg in 1 tablet.
Excipients: - Mannitol.
- Calcium hydrogen phosphate dihydrate.
- Pregelatinized corn starch.
- Croscarmellose sodium.
- Magnesium Stearate.
Dosage and administration of
Arterial hypertension For arterial hypertension, patients not receiving other antihypertensive drugs are prescribed 5 mg 1 time / day. If there is no effect, the dose is increased every 2-3 days by 5 mg to an average therapeutic dose of 20-40 mg / day (increasing the dose of more than 40 mg / day usually does not lead to a further decrease in blood pressure). The usual daily maintenance dose is 20 mg. The maximum daily dose is 40 mg. The full effect usually develops after 2-4 weeks from the start of treatment, which should be taken into account when increasing the dose. With insufficient clinical effect, it is possible to combine the drug with other antihypertensive drugs. If the patient received preliminary treatment with diuretics, then their reception must be stopped 2-3 days before the start of the use of lisinotone. If it is impossible to cancel diuretics, then the initial dose of Lysinotone should not exceed
Side effects
From the cardiovascular system: often - orthostatic hypotension, chest pain (1-3%) rarely (From the central nervous system: often - dizziness, headache (5-6%), weakness rarely (From digestive system: often - nausea, vomiting, diarrhea rarely (From the respiratory system: often (3%) - dry cough.
From the hematopoietic system: possibly - leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with prolonged treatment - a slight decrease in hemoglobin concentration and hematocrit, erythrocytopenia.s rdlkp On the part of the immune system: (0.1%) angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities) rarely (From the urinary system: rarely (Dermatological reactions: often - a skin rash is rare (Laboratory parameters: hyperkalemia, azotemia, hyperuricemia, hyperbilirubinemia, increased activity of liver enzymes (especially if there is a history of kidney disease, diabetes mellitus and renovascular hypertension).
Other: rarely (
Drug Interactions
When used simultaneously with diuretics, lisinopril decreases potassium excretion.
With extreme caution, lisinotone should be prescribed simultaneously with potassium-sparing diuretics (spironolactone, triamteren, amiloride), potassium, salt substitutes containing potassium, as the risk of developing hyperkalemia increases, especially with impaired renal function. Therefore, these combinations should be prescribed only on the basis of an individual decision of the attending physician with regular monitoring of serum potassium levels and renal function.
When used simultaneously with diuretics and other antihypertensive drugs, an additive antihypertensive effect develops.
When used simultaneously with NSAIDs (including indomethacin), estrogens, and also adrenostimulants, the antihypertensive effect of lisinopril is reduced.
When used simultaneously with lithium, lithium excretion may decrease, therefore, serum lithium concentration should be regularly monitored.
With simultaneous use with antacids and colestyramine, absorption of lisinopril from the gastrointestinal tract is reduced.
With the simultaneous use of ethanol enhances the effect of lisinopril.
overdose
Symptoms: marked decrease in blood pressure, dry mouth, drowsiness, delayed urination, constipation, anxiety, irritability (occur when taking a single dose of 50 mg).
Treatment: carry out symptomatic therapy if necessary (in / in the introduction of fluid, control and normalization of blood pressure, water-electrolyte balance).
Lisinopril is excreted by hemodialysis.
Storage Conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life
3 years.
eystvuyushtee substance
Lisinopril
Terms and conditions
prescription
dosage form
tablets
Possible product names
Lysinotone 10mg No. 28
LYSINOTON 0.01 N28 TABLE
Lysinotone 10mg Tab. X28 (R)
Lysinotone 10mg Tab. X28 (R) /! Until 03.11g /
Lisinoton tab. 10mg x 28
Actavis Ltd, Iceland
lisinotone tablets 10 mg 28 pcs. (Lisinopril) florida in pharmacy online. Cheap price, instruction, side effects, dosage. lisinotone tablets 10 mg 28 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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